Featured Publications
Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons
Clark-Boucher D, Zhou X, Du J, Liu Y, Needham B, Smith J, Mukherjee B. Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons. PLOS Genetics 2023, 19: e1011022. PMID: 37934796, PMCID: PMC10655967, DOI: 10.1371/journal.pgen.1011022.Peer-Reviewed Original ResearchConceptsBayesian Sparse Linear Mixed ModelMediation analysisHigh-dimensional mediation analysisMulti-ethnic cohortEpigenetic researchHealth outcomesHigh-dimensional DNA methylation dataLinear mixed modelsDNA methylation dataContinuous outcomesEvaluate DNA methylationDNA methylationMethylation dataDNAm dataMixed modelsDiverse simulationsSeamless implementationModern statistical methodsMediation effectR packageUnited StatesOutcomes
2024
Decomposing the association of psychosocial wellbeing with all-cause mortality: the mediating role of physical health and lifestyle factors
Alimujiang A, Strecher V, McLean K, Mondul A, Pearce C, Mukherjee B. Decomposing the association of psychosocial wellbeing with all-cause mortality: the mediating role of physical health and lifestyle factors. Social Psychiatry And Psychiatric Epidemiology 2024, 1-11. PMID: 39044017, DOI: 10.1007/s00127-024-02717-y.Peer-Reviewed Original ResearchLifestyle factorsPhysical healthWellbeing groupsPsychosocial wellbeingU.S. Health and Retirement StudyEffects of physical healthHealth and Retirement StudyTotal effectHealth index measureMediation analysisMethodsLatent class analysisRetirement StudyPsychosocial constructsSignificant total effectsLifestyleHealthPurposeThis studyClass analysisConclusionOur findingsWellbeingSummation effectMortalityGroupParticipantsFactors
2021
Bayesian Sparse Mediation Analysis with Targeted Penalization of Natural Indirect Effects
Song Y, Zhou X, Kang J, Aung M, Zhang M, Zhao W, Needham B, Kardia S, Liu Y, Meeker J, Smith J, Mukherjee B. Bayesian Sparse Mediation Analysis with Targeted Penalization of Natural Indirect Effects. Journal Of The Royal Statistical Society Series C (Applied Statistics) 2021, 70: 1391-1412. PMID: 34887595, PMCID: PMC8653861, DOI: 10.1111/rssc.12518.Peer-Reviewed Original ResearchNatural indirect effectMulti-Ethnic Study of AtherosclerosisMediation analysisMediator-outcome effectsMulti-Ethnic StudyStudy of AtherosclerosisCausal mediation analysisLIFECODES birth cohortBirth cohortEpidemiological studiesJoint prior distributionPotential mediatorsHigh-dimensional mediation analysisGaussian mixtureHigh-dimensional mediatorsIndirect effectsPrior distributionEstimation accuracyExposure-mediated effectsBayesian paradigmExposure effectsAvailability of measurementsComposite structuresIncreasing availability of measurementsBayesian hierarchical models for high‐dimensional mediation analysis with coordinated selection of correlated mediators
Song Y, Zhou X, Kang J, Aung M, Zhang M, Zhao W, Needham B, Kardia S, Liu Y, Meeker J, Smith J, Mukherjee B. Bayesian hierarchical models for high‐dimensional mediation analysis with coordinated selection of correlated mediators. Statistics In Medicine 2021, 40: 6038-6056. PMID: 34404112, PMCID: PMC9257993, DOI: 10.1002/sim.9168.Peer-Reviewed Original Research
2019
Bayesian Shrinkage Estimation of High Dimensional Causal Mediation Effects in Omics Studies
Song Y, Zhou X, Zhang M, Zhao W, Liu Y, Kardia S, Roux A, Needham B, Smith J, Mukherjee B. Bayesian Shrinkage Estimation of High Dimensional Causal Mediation Effects in Omics Studies. Biometrics 2019, 76: 700-710. PMID: 31733066, PMCID: PMC7228845, DOI: 10.1111/biom.13189.Peer-Reviewed Original ResearchConceptsMediation analysisEffect of socioeconomic statusPotential mediatorsMulti-Ethnic StudyCausal mediation analysisCardiometabolic outcomesDNA methylation regionsSocioeconomic statusHigh-throughput technologiesMediation effectGenomic dataEpidemiological dataMethylation regionsHigh-dimensional mediatorsBayesian inference methodsContinuous shrinkage priorsHigh-dimensional settingsBayesian shrinkage estimatorsJoint analysisOutcomesShrinkage priorsPathwayNull caseInference methodsBiomedical studies
2016
Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Ferguson K, Chen Y, VanderWeele T, McElrath T, Meeker J, Mukherjee B. Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environmental Health Perspectives 2016, 125: 488-494. PMID: 27352406, PMCID: PMC5332184, DOI: 10.1289/ehp282.Peer-Reviewed Original ResearchConceptsExposure-mediator interactionPreterm birthMaternal phthalate exposureNested case-control study of preterm birthCase-control study of preterm birthNested case-control studyPhthalate exposureStudy of preterm birthPhthalate metabolitesOxidative stressSpontaneous preterm birthLongitudinal measurementsMetabolites of di(2-ethylhexyl) phthalateOdds ratioRepeated measuresDi(2-ethylhexyl) phthalateMediation analysisRegression modelsOxidative stress biomarkersEstimated proportionPretermPregnancyInteraction termsBirthAssociation