2022
Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico
Ashrap P, Aung M, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 384-391. PMID: 35075242, PMCID: PMC9124693, DOI: 10.1038/s41370-022-00410-3.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesPhthalate metabolitesPlasmenyl-phosphatidylcholinesPregnant womenPuerto Rico PROTECT cohortPhthalate exposureLipidomic profilesMaternal urinary phthalate metabolitesWeeks of pregnancyMetabolite biomarkersMetabolites of di-2-ethylhexyl phthalateChild health outcomesCirculating lipid concentrationsLipidomic markersShotgun lipidomicsFatty acid chainsLipidomic signaturePROTECT cohortLipid profileCell-to-cell signalingImpactThis studyPregnancyAcid chainsPlasma samplesHealth outcomesMaternal Metals/Metalloid Blood Levels Are Associated With Lipidomic Profiles Among Pregnant Women in Puerto Rico
Kim C, Ashrap P, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal Metals/Metalloid Blood Levels Are Associated With Lipidomic Profiles Among Pregnant Women in Puerto Rico. Frontiers In Public Health 2022, 9: 754706. PMID: 35096734, PMCID: PMC8790322, DOI: 10.3389/fpubh.2021.754706.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesBlood levelsPlasmenyl-phosphatidylcholinesLipidomic profilesBirth outcomesPlasmenyl phosphatidylethanolamineWeeks of pregnancyPlasma lipidomic profilesMultiple comparisonsLipid sub-classesHeavy metal exposurePolyunsaturated fatty acidsPregnant womenShotgun lipidomicsMetal exposureImportant signaling pathwaysAssessed associationsBiomarker profilesAssociated with lipidEarly detectionBirth cohortDiagnostic toolExposure to manganeseSignaling pathwayFalse discovery rate
2021
Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
Aung M, Ashrap P, Watkins D, Mukherjee B, Rosario Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates. Scientific Reports 2021, 11: 8115. PMID: 33854141, PMCID: PMC8046995, DOI: 10.1038/s41598-021-87472-9.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthBiomarkers of pregnancy outcomesGestational age neonatesPreterm birthAge neonatesPregnancy outcomesDegree of hydrocarbon chain saturationIncreased riskNeonatal anthropometric parametersAssociated with increased riskPlasmenyl phosphatidylethanolamineMaternal lipidomeWeeks gestationGestational ageLipidomic signatureAnthropometric parametersLiquid chromatography tandem mass spectrometryLipidomic profilesLipid metabolitesHydrocarbon chain saturationPlasma samplesBirthLogistic regressionHigh-performance liquid chromatography tandem mass spectrometryNeonates
2020
Maternal Urinary Phthalate Metabolites are Associated with Lipidomic Profiles Among Pregnant Women in Puerto Rico
Ashrap P, Watkins D, Mukherjee B, Rosario Z, M. C, Alshawabkeh A, Cordero J, Meeker J. Maternal Urinary Phthalate Metabolites are Associated with Lipidomic Profiles Among Pregnant Women in Puerto Rico. ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-1070.Peer-Reviewed Original Research