Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals
Aung M, Meeker J, Boss J, Bakulski K, Mukherjee B, Cantonwine D, McElrath T, Ferguson K. Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals. Reproductive Toxicology 2019, 93: 43-53. PMID: 31881266, PMCID: PMC7138746, DOI: 10.1016/j.reprotox.2019.12.004.Peer-Reviewed Original ResearchConceptsIL-1BBayesian kernel machine regressionKernel machine regressionInterleukin-1bInterquartile range differenceCross-sectional studyAssociated with biomarkersReproductive health outcomesImmune signaling moleculesHealth outcomesLIFECODES birth cohortPregnant womenImmune perturbationsImmune biomarkersBirth cohortUrinary manganeseMachine regressionLinear regressionExposure analytesAssociationSignaling moleculesRegressionPair-wise associationsTrimesterPregnancyExpression of socially sensitive genes: The multi-ethnic study of atherosclerosis
Brown K, Diez-Roux A, Smith J, Needham B, Mukherjee B, Ware E, Liu Y, Cole S, Seeman T, Kardia S. Expression of socially sensitive genes: The multi-ethnic study of atherosclerosis. PLOS ONE 2019, 14: e0214061. PMID: 30973896, PMCID: PMC6459532, DOI: 10.1371/journal.pone.0214061.Peer-Reviewed Original ResearchConceptsGene expressionSocial factorsAdult socioeconomic statusPopulation-based cohortMulti-Ethnic StudyMarginal significant associationPercentage of genesInfluence gene expressionLinear regressionExpression of genesLifetime discriminationSocioeconomic statusChronic burdenOverall healthInvestigate associationsGene approachGene setsLinear regression analysisSignificant associationGenesExpression patternsMultiple testingSensitive to social factorsCell typesRegression analysis