2023
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort
Goutman S, Boss J, Jang D, Mukherjee B, Richardson R, Batterman S, Feldman E. Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort. Journal Of Neurology Neurosurgery & Psychiatry 2023, 95: 241-248. PMID: 37758454, PMCID: PMC11060633, DOI: 10.1136/jnnp-2023-332121.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreAmyotrophic lateral sclerosis riskPersistent organic pollutantsALS riskInterquartile increaseHigher ALS riskAssociated with ALS riskModify disease riskOrganochlorine pesticidesAssociated with riskRisk reduction strategiesPersistent organic pollutant analysisIndividual persistent organic pollutantsPersistent organic pollutant mixturesHazard ratioDisease riskRisk scoreCase/control cohortEnvironmental exposuresControl participantsGenetic susceptibilityPolychlorinated biphenylsAlpha-hexachlorocyclohexaneOrganic pollutantsMortality rate
2022
Associations of self-reported occupational exposures and settings to ALS: a case–control study
Goutman S, Boss J, Godwin C, Mukherjee B, Feldman E, Batterman S. Associations of self-reported occupational exposures and settings to ALS: a case–control study. International Archives Of Occupational And Environmental Health 2022, 95: 1567-1586. PMID: 35593931, PMCID: PMC9424174, DOI: 10.1007/s00420-022-01874-4.Peer-Reviewed Original ResearchConceptsStandard Occupational ClassificationStandard Occupational Classification codesExposure to particulate matterProductive occupationsALS riskSelf-reported occupational exposureHigher risk of amyotrophic lateral sclerosisOccupational exposureHigher ALS riskRisk of amyotrophic lateral sclerosisRisk factor modificationOccupational exposure to particulate matterExposure surveyIncreased ALS riskCase-control studyMaintenance occupationsGrounds cleaningFactor modificationExposure scoreTargeted screeningAmyotrophic lateral sclerosis diagnosisRepair occupationsAdaptive elastic net modelOccupational classificationProgressive neurological disease