2022
Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals
Fang Y, Fritsche L, Mukherjee B, Sen S, Richmond-Rakerd L. Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals. Biological Psychiatry 2022, 92: 923-931. PMID: 35965108, PMCID: PMC10712651, DOI: 10.1016/j.biopsych.2022.06.004.Peer-Reviewed Original ResearchConceptsPhenome-wide association studyPolygenic risk scoresMDD PRSHealth recordsRisk scoreAssociation studiesGenome-wide polygenic risk scoreAssociated with multiple medical conditionsMeasures of genetic riskMichigan Genomics InitiativePsychiatric traitsElectronic health recordsEuropean ancestry participantsMajor depressive disorderAssociated with tobacco use disorderTests of associationMultiple medical conditionsGenitourinary conditionsTobacco use disorderDisease-associated disabilityMolecular genetic toolsMolecular genetic discoveriesPsychiatric disease categoriesHealth outcomesSubstance-related disorders
2021
A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine
Salvatore M, Gu T, Mack J, Sankar S, Patil S, Valley T, Singh K, Nallamothu B, Kheterpal S, Lisabeth L, Fritsche L, Mukherjee B. A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine. Journal Of Clinical Medicine 2021, 10: 1351. PMID: 33805886, PMCID: PMC8037108, DOI: 10.3390/jcm10071351.Peer-Reviewed Original ResearchPhenome-wide association studyCOVID-19 outcomesIntensive care unitAssociation studiesNon-Hispanic blacksNon-Hispanic whitesAcademic medical centerAssociated with hospitalizationHealthcare deliveryAssociated with mortalityMedicine backgroundPre-existing conditionsMedical phenomeDisease preventionVulnerable populationsPulmonary heart diseaseTargeted screeningMental disordersCOVID-19Associated with intensive care unitMedical CenterRecord DataCare unitGenitourinary conditionsHeart disease