Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction
Zhuang Y, Kim N, Fritsche L, Mukherjee B, Lee S. Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction. BMC Bioinformatics 2024, 25: 65. PMID: 38336614, PMCID: PMC11323637, DOI: 10.1186/s12859-024-05664-2.Peer-Reviewed Original ResearchConceptsPredictive performance of polygenic risk scoresFunctional annotationGenetic architecturePerformance of polygenic risk scoresPRS-CSAnnotation informationPolygenic risk predictionGenetic risk predictionPolygenic risk scoresFunctional annotation informationKyoto Encyclopedia of GenesRisk predictionProportion of variantsEncyclopedia of GenesGenomes (KEGGSource of annotationTrait heritabilityAnnotation groupsPathway informationQuantitative traitsKyoto EncyclopediaFunctional categoriesBackgroundGenetic variantsHeritable contributionReal world data sources