2024
Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study
Jang D, Dou J, Koubek E, Teener S, Zhou L, Bakulski K, Mukherjee B, Batterman S, Feldman E, Goutman S. Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study. Journal Of Neurology Neurosurgery & Psychiatry 2024, jnnp-2024-333978. PMID: 39107037, DOI: 10.1136/jnnp-2024-333978.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosis riskEnvironmental risk scoreAssociated with ALS riskALS riskGenetic riskRisk scorePolygenic risk scoresSelf-reported exposureGenome-wide association studiesStudy investigated associationsCase-control studySingle-nucleotide polymorphismsAssociation studiesExposure mixturesControl participantsExposure sourcesRiskParticipantsAmyotrophic lateral sclerosisSurvival modelsScoresAssociationEnvironmental factorsUrine metalsUrine samples
2021
A hierarchical integrative group least absolute shrinkage and selection operator for analyzing environmental mixtures
Boss J, Rix A, Chen Y, Narisetty N, Wu Z, Ferguson K, McElrath T, Meeker J, Mukherjee B. A hierarchical integrative group least absolute shrinkage and selection operator for analyzing environmental mixtures. Environmetrics 2021, 32 PMID: 34899005, PMCID: PMC8664243, DOI: 10.1002/env.2698.Peer-Reviewed Original ResearchGroup least absolute shrinkageEnvironmental health studiesHealth outcomesHealth StudyLIFECODES birth cohortBirth cohortExposure interactionsPenalized regression methodsDose-response relationshipExposure mixturesComprehensive R Archive NetworkInteraction effectsInduce sparsityAdaptive weightsGroup lassoSelection operatorHeredity constraintLeast Absolute ShrinkageSelection frameworkNonlinear interaction effectsSample sizeVariable selectionJoint effectsCoefficient estimatesGroup structure