2017
Exposure enriched outcome dependent designs for longitudinal studies of gene–environment interaction
Sun Z, Mukherjee B, Estes J, Vokonas P, Park S. Exposure enriched outcome dependent designs for longitudinal studies of gene–environment interaction. Statistics In Medicine 2017, 36: 2947-2960. PMID: 28497531, PMCID: PMC5523112, DOI: 10.1002/sim.7332.Peer-Reviewed Original ResearchConceptsLongitudinal cohort studyCohort studyCase-only designLongitudinal studyG x E interactionNormative Aging StudyComplete-case analysisGene-environmentSampling designCase-controlVeterans AdministrationComplex human diseasesE interactionExposure informationAging StudyOutcome trajectoriesStratified samplingRetrospective genotypingIndividual exposureCovariate dataExposure effectsJoint effectsOutcomesTime-varying outcomeEnvironmental factors
2014
The impact of exposure-biased sampling designs on detection of gene–environment interactions in case–control studies with potential exposure misclassification
Stenzel S, Ahn J, Boonstra P, Gruber S, Mukherjee B. The impact of exposure-biased sampling designs on detection of gene–environment interactions in case–control studies with potential exposure misclassification. European Journal Of Epidemiology 2014, 30: 413-423. PMID: 24894824, PMCID: PMC4256150, DOI: 10.1007/s10654-014-9908-1.Peer-Reviewed Original ResearchConceptsG-E interactionsExposure informationDetection of gene-environment interactionsPrevalence of exposureGene-environment interactionsSampling designCase-control studyRandom selection of subjectsPerformance of sampling designsCase-onlyExposure prevalenceJoint testExposure misclassificationCase-controlRare exposuresMarginal associationSelection of subjectsType I errorEmpirical simulation studyIdeal sampling schemesJoint effectsPrevalenceRandom selectionG-EMisclassification