2011
Testing Gene-Environment Interaction in Large-Scale Case-Control Association Studies: Possible Choices and Comparisons
Mukherjee B, Ahn J, Gruber S, Chatterjee N. Testing Gene-Environment Interaction in Large-Scale Case-Control Association Studies: Possible Choices and Comparisons. American Journal Of Epidemiology 2011, 175: 177-190. PMID: 22199027, PMCID: PMC3286201, DOI: 10.1093/aje/kwr367.Peer-Reviewed Original ResearchConceptsGene-environment independenceGene-environment interactionsCase-only methodTesting gene-environment interactionsCase-control testsExposure under studyCase-control association studyUnderlying populationCase-control methodCase-control analysisFraction of markersType I error propertiesGenome-wide scanClass of proceduresAssociation studiesData-adaptive wayComparative simulation studyLarge-scale studiesEmpirical-BayesIndependence assumptionFalse positivesPopulationReplication strategyHybrid methodIndependenceAsthma exacerbation and proximity of residence to major roads: a population-based matched case-control study among the pediatric Medicaid population in Detroit, Michigan
Li S, Batterman S, Wasilevich E, Elasaad H, Wahl R, Mukherjee B. Asthma exacerbation and proximity of residence to major roads: a population-based matched case-control study among the pediatric Medicaid population in Detroit, Michigan. Environmental Health 2011, 10: 34. PMID: 21513554, PMCID: PMC3224543, DOI: 10.1186/1476-069x-10-34.Peer-Reviewed Original ResearchConceptsConditional logistic regressionPopulation-based matched case-control studyPediatric Medicaid populationCase-control studyMedicaid populationProximity of residenceLogistic regressionConditional logistic regression modelsElevated risk of asthmaRisk of asthmaEmergency department visitsCase-control analysisLogistic regression modelsHigh-risk populationTraffic-related pollutantsAsthma outcomesDepartment visitsAsthma eventsAsthma claimAsthma-related eventsAsthma casesEcological biasOdds ratioInvestigate associationsMethodThis study
2008
Tests for gene‐environment interaction from case‐control data: a novel study of type I error, power and designs
Mukherjee B, Ahn J, Gruber S, Rennert G, Moreno V, Chatterjee N. Tests for gene‐environment interaction from case‐control data: a novel study of type I error, power and designs. Genetic Epidemiology 2008, 32: 615-626. PMID: 18473390, DOI: 10.1002/gepi.20337.Peer-Reviewed Original ResearchConceptsGene-environment independence assumptionCase-control studyGene-environment interactionsGene-environment associationsCase-onlyCase-control study of colorectal cancerDetection of gene-environment interactionsType I errorGene-environment dependenceStudy of colorectal cancerGene-environment independenceEffect of genetic susceptibilityCase-only methodCase-only estimatorCase-control estimatorsCase-control dataGene-environment effectsCase-control designCase-control methodCase-control analysisGlutathione S-transferase M1Empirical-BayesEpidemiological researchCase-controlColorectal cancer