2018
Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children
Lewis T, Metitiri E, Mentz G, Ren X, Carpenter A, Goldsmith A, Wicklund K, Eder B, Comstock A, Ricci J, Brennan S, Washington G, Owens K, Mukherjee B, Robins T, Batterman S, Hershenson M. Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children. Respiratory Research 2018, 19: 228. PMID: 30463560, PMCID: PMC6249926, DOI: 10.1186/s12931-018-0922-9.Peer-Reviewed Original ResearchConceptsViral infectionLung functionAbsence of viral infectionIL-13IL-4Viral-induced asthma exacerbationsRespiratory illnessRespiratory viral infectionsAssociated with increased cytokinesPro-inflammatory cytokinesLung function declineSelf-reported respiratory illnessInfluence of viral infectionAirway cytokinesMDA5 mRNACXCL10 mRNACytokine levelsAirway responsivenessNasal lavageAirflow obstructionAssociated with FVCAsthma exacerbationsAssociated with decreased lung functionInflammatory responseNasal samples
2012
Nasal cytokine responses to natural colds in asthmatic children
Lewis T, Henderson T, Carpenter A, Ramirez I, McHenry C, Goldsmith A, Ren X, Mentz G, Mukherjee B, Robins T, Joiner T, Mohammad L, Nguyen E, Burns M, Burke D, Hershenson M. Nasal cytokine responses to natural colds in asthmatic children. Clinical & Experimental Allergy 2012, 42: 1734-1744. PMID: 23181789, PMCID: PMC4219353, DOI: 10.1111/cea.12005.Peer-Reviewed Original ResearchConceptsViral infectionMarker elevationSymptom scoresMarkers of viral infectionRespiratory viral infectionsRobust innate immune responsePresence of viral infectionRespiratory symptom scoresMultiplex immune assaysRespiratory tract symptomsSelf-reported respiratory illnessCCL11/eotaxin-1IFN-responsive genesInnate immune responseWeeks of assessmentNasal aspiratesCXCL10/IP-10CCL7/MCP-3IFN-gCCL2/MCP-1IRF7 mRNACXCL8/IL-8Asthma exacerbationsImmune responseMRNA signal