2021
Exposure to Primary Air Pollutants Generated by Highway Traffic and Daily Mortality Risk in Near-Road Communities: A Case-Crossover Study
Filigrana P, Milando C, Batterman S, Levy J, Mukherjee B, Pedde M, Szpiro A, Adar S. Exposure to Primary Air Pollutants Generated by Highway Traffic and Daily Mortality Risk in Near-Road Communities: A Case-Crossover Study. American Journal Of Epidemiology 2021, 191: 63-74. PMID: 34347034, DOI: 10.1093/aje/kwab215.Peer-Reviewed Original ResearchConceptsNear-road populationsAir pollutionMortality riskExposure to traffic-related air pollutionAverage PM2.5 exposureTraffic-generated air pollutionNear-road communitiesResearch LINE sourceConcentrations of PM2.5Traffic-related air pollutionCase-crossover designPrimary air pollutantsConditional logistic regressionPuget Sound area of Washington StateDaily mortality riskCase-crossoverTime-varying covariatesCerebrovascular mortalityPM2.5 exposurePrimary pollutantsQuantify associationsAerodynamic diameterShorter averaging periodsPM2.5PollutionOpportunities and challenges in reducing personal inhalation exposure to air pollution among electronic waste recovery workers in Ghana
Laskaris Z, Batterman S, Arko‐Mensah J, Mukherjee B, Fobil J, O'Neill M, Robins T. Opportunities and challenges in reducing personal inhalation exposure to air pollution among electronic waste recovery workers in Ghana. American Journal Of Industrial Medicine 2021, 64: 381-397. PMID: 33522624, PMCID: PMC8046737, DOI: 10.1002/ajim.23229.Peer-Reviewed Original ResearchConceptsPersonal PM<sub>2.5</sub>Burning e-wasteE-wasteHigh PM<sub>2.5</sub> concentrationsAgbogbloshie e-waste siteExposure to air pollutionExposure to particulate matterSize-specific PMInhalation exposure to particulate matterE-waste sitesE-waste workersLevels of PMPM samplesParticulate matterBurning activitiesAir pollutionTime-activityTime-activity dataElectronic wasteWorker's breathing zonePersonal samplesToxic emissionsLinear mixed modelsSite locationWind direction
2018
Distributed Lag Interaction Models with Two Pollutants
Chen Y, Mukherjee B, Berrocal V. Distributed Lag Interaction Models with Two Pollutants. Journal Of The Royal Statistical Society Series C (Applied Statistics) 2018, 68: 79-97. PMID: 30636815, PMCID: PMC6328049, DOI: 10.1111/rssc.12297.Peer-Reviewed Original ResearchMean square errorEffects of air pollutionDistributed lag modelsAir pollution studiesHealth outcomesNational MorbidityBias-variance tradeoffEnvironmental epidemiologyAir pollutionPollution studiesPollutionLag effectMortality countsMain effectTensor productShrinkage methodShrinkage versionAverage performanceNatural waySimulation studyJoint effectsInteraction structureMortalityNMMAPSMorbidity
2017
Robust distributed lag models using data adaptive shrinkage
Chen Y, Mukherjee B, Adar S, Berrocal V, Coull B. Robust distributed lag models using data adaptive shrinkage. Biostatistics 2017, 19: 461-478. PMID: 29040386, PMCID: PMC6454578, DOI: 10.1093/biostatistics/kxx041.Peer-Reviewed Original ResearchConceptsDistributed lag modelsDistributed LagLag modelTime series dataEffects of air pollutionBias-variance trade-offGeneralized ridge regressionShrinkage methodAir pollution studiesHierarchical Bayes approachShrinkage approachTime seriesDl functionAir pollutionPollution studiesEffect estimatesTrade-offsExtensive simulation studyDependent variableShrinking coefficientsMean square errorLagSimulation studyBayes approachRidge regression
2015
Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance
Brook R, Sun Z, Brook J, Zhao X, Ruan Y, Yan J, Mukherjee B, Rao X, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q, Gu D, Sun Q, Fan Z, Rajagopalan S. Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance. Hypertension 2015, 67: 77-85. PMID: 26573709, PMCID: PMC4830086, DOI: 10.1161/hypertensionaha.115.06237.Peer-Reviewed Original ResearchConceptsFine particulate matterParticulate matterAmbient fine particulate matterSD increaseAssociated with worsening insulin resistanceBlack carbon levelsBlack carbon exposurePublic health warningsAir pollutionBeijing metropolitan areaBlack carbonHealth warningsAssociated with rangeCardiometabolic healthCarbon levelsDiastolic blood pressureExposure windowsCardiometabolic diseasesHealth effectsNonsmoking adultsMetabolic syndromeDeveloping world todayCarbon exposureSystolic blood pressure elevationHealth
2014
Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes
Liu C, Fonken L, Wang A, Maiseyeu A, Bai Y, Wang T, Maurya S, Ko Y, Periasamy M, Dvonch T, Morishita M, Brook R, Harkema J, Ying Z, Mukherjee B, Sun Q, Nelson R, Rajagopalan S. Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Particle And Fibre Toxicology 2014, 11: 53. PMID: 25358444, PMCID: PMC4226918, DOI: 10.1186/s12989-014-0053-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAnti-Inflammatory AgentsBenzamidesBlood GlucoseDiabetes Mellitus, Type 2Disease Models, AnimalEnergy MetabolismHypothalamusI-kappa B KinaseInflammationInfliximabInhalation ExposureInjections, IntraventricularInsulinInsulin ResistanceInterleukin-6MiceOxygen ConsumptionParticulate MatterProtein Kinase InhibitorsRisk AssessmentRNA, MessengerThermogenesisTime FactorsTumor Necrosis Factor-alphaA Comparison of Exposure Metrics for Traffic-Related Air Pollutants: Application to Epidemiology Studies in Detroit, Michigan
Batterman S, Burke J, Isakov V, Lewis T, Mukherjee B, Robins T. A Comparison of Exposure Metrics for Traffic-Related Air Pollutants: Application to Epidemiology Studies in Detroit, Michigan. International Journal Of Environmental Research And Public Health 2014, 11: 9553-9577. PMID: 25226412, PMCID: PMC4199035, DOI: 10.3390/ijerph110909553.Peer-Reviewed Original ResearchConceptsTraffic-related air pollutionAir pollutionTraffic densityTraffic emissionsExposure metricsDispersion modelTransportation planning studiesSource of air pollutant emissionsComparison of exposure distributionNear-road environmentExposure to traffic-related air pollutionEmission densityAir pollutant emissionsAir pollution epidemiologyDispersion modeling systemVehicle mixEpidemiological studiesTraffic volumePollutant concentrationsSpatial variabilityResidential locationHealth risksTrafficPollutionProximity classificationHemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter Air Pollution from a Rural Location
Brook R, Bard R, Morishita M, Dvonch J, Wang L, Yang H, Spino C, Mukherjee B, Kaplan M, Yalavarthi S, Oral E, Ajluni N, Sun Q, Brook J, Harkema J, Rajagopalan S. Hemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter Air Pollution from a Rural Location. Environmental Health Perspectives 2014, 122: 624-630. PMID: 24618231, PMCID: PMC4050508, DOI: 10.1289/ehp.1306595.Peer-Reviewed Original ResearchConceptsCoarse PMParticulate matterAir pollutionRural locationsCoarse particlesParticulate matter air pollutionCoarse PM exposureAssociated with numerous adverse health effectsAcute CV eventsBlood pressureFine particulate matterAmbient coarse particlesNumerous adverse health effectsGlobal air pollutionAdverse health effectsHeart rateFrequency heart rate variabilityCoarse CAPPM exposureFiltered airRandomized double-blind crossover studyDiastolic BPDouble-blind crossover studyHealth effectsHealthy adultsPersonal Black Carbon Exposure Influences Ambulatory Blood Pressure
Zhao X, Sun Z, Ruan Y, Yan J, Mukherjee B, Yang F, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q, Gu D, Brook J, Sun Q, Brook R, Rajagopalan S, Fan Z. Personal Black Carbon Exposure Influences Ambulatory Blood Pressure. Hypertension 2014, 63: 871-877. PMID: 24420543, PMCID: PMC4445364, DOI: 10.1161/hypertensionaha.113.02588.Peer-Reviewed Original ResearchConceptsPersonal black carbonAir pollutionBlack carbonBeijing Municipal Environmental Monitoring CenterFine particulate matter concentrationsCombustion-related air pollutionFine particulate matterAmbulatory blood pressureEnvironmental Monitoring CenterParticulate matter concentrationsBlood pressureHigh air pollutionReduce air pollutionMm HgLow frequency to high frequency ratioPublic health effectsParticulate matterTwenty-four-hour ambulatory blood pressureExposure to high levelsMatter concentrationSystolic blood pressureDiastolic blood pressurePollutionBlood pressure effectsGeneralized linear model
2013
Cardiovascular Depression in Rats Exposed to Inhaled Particulate Matter and Ozone: Effects of Diet-Induced Metabolic Syndrome
Wagner J, Allen K, Yang H, Nan B, Morishita M, Mukherjee B, Dvonch J, Spino C, Fink G, Rajagopalan S, Sun Q, Brook R, Harkema J. Cardiovascular Depression in Rats Exposed to Inhaled Particulate Matter and Ozone: Effects of Diet-Induced Metabolic Syndrome. Environmental Health Perspectives 2013, 122: 27-33. PMID: 24169565, PMCID: PMC3888573, DOI: 10.1289/ehp.1307085.Peer-Reviewed Original ResearchConceptsHFrD ratsBlood pressureND ratsHeart rateMetabolic syndromeHR variabilityFasting levels of blood glucoseNormal dietMale Sprague-Dawley ratsParticulate matterAssociated with cardiovascular morbidityCardiovascular depressionAir pollutionSprague-Dawley ratsDiet-induced metabolic syndromeElevated fasting levelsToxicity of air pollutantsFine particulate matterHigh-fructose dietLevels of blood glucoseInhalable particulate matterLevels of ozoneInduce MetSCardiovascular morbidityExaggerated BPThe effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study
Brook R, Bard R, Kaplan M, Yalavarthi S, Morishita M, Dvonch J, Wang L, Yang H, Spino C, Mukherjee B, Oral E, Sun Q, Brook J, Harkema J, Rajagopalan S. The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study. Inhalation Toxicology 2013, 25: 587-592. PMID: 23919441, PMCID: PMC4364610, DOI: 10.3109/08958378.2013.814733.Peer-Reviewed Original ResearchConceptsCirculating endothelial progenitor cellsRural locationsVascular endothelial growth factorEndothelial progenitor cellsCirculating EPC levelsCoarse PMWhite blood cellsParticulate matterConcentrated ambient particlesParticulate matter air pollutionAir pollutionFine particulate matterEPC levelsProgenitor cellsWilcoxon signed-rank testRandomized double-blind crossover studyDouble-blind crossover studyFiltered airSigned-rank testBlood cellsPeripheral venous bloodSympathetic nervous system activityEndothelial growth factorAssociated with alterationsCardiovascular disease
2012
Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area
Lewis T, Robins T, Mentz G, Zhang X, Mukherjee B, Lin X, Keeler G, Dvonch J, Yip F, O'Neill M, Parker E, Israel B, Max P, Reyes A, Committee C. Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area. The Science Of The Total Environment 2012, 448: 48-55. PMID: 23273373, PMCID: PMC4327853, DOI: 10.1016/j.scitotenv.2012.11.070.Peer-Reviewed Original ResearchConceptsParticulate matterAir pollutionAssociated with negative health impactsAmbient pollutant concentrationsAir quality standardsAmbient air pollutionAmbient particulate matterEffective risk reduction interventionsOdds of respiratory symptomsAsthmatic childrenFactors associated with heterogeneityAssociated with increased oddsObserved health effectsRespiratory symptomsRisk reduction interventionsPopulation of asthmatic childrenRespiratory symptom diariesOutdoor PMDaily concentrationsPollutant concentrationsMonitoring sitesGeneralized estimating equationsPollution modelLogistic regression modelsAerodynamic diameterAir-Pollution and Cardiometabolic Diseases (AIRCMD): A prospective study investigating the impact of air pollution exposure and propensity for type II diabetes
Sun Z, Mukherjee B, Brook R, Gatts G, Yang F, Sun Q, Brook J, Fan Z, Rajagopalan S. Air-Pollution and Cardiometabolic Diseases (AIRCMD): A prospective study investigating the impact of air pollution exposure and propensity for type II diabetes. The Science Of The Total Environment 2012, 448: 72-78. PMID: 23182147, PMCID: PMC4548977, DOI: 10.1016/j.scitotenv.2012.10.087.Peer-Reviewed Original ResearchConceptsAir pollution exposureAir pollutionAmbient fine particulate matterMeasures of air pollution exposureImpact of air pollution exposureFine particulate matterExposure to PM2.5Air pollution measurementsPersonal exposure measurementsCreation of novel methodologiesSub-acute exposurePolluted urban environmentsImpact of environmental factorsParticulate matterPollution exposureStudy visitsPollution measurementsType II diabetesProspective cohort studyEnvironmental risk factorsAmbient measurementsII diabetesCohort studyUrban environmentScreening visit
2011
Association of daily asthma emergency department visits and hospital admissions with ambient air pollutants among the pediatric Medicaid population in Detroit: Time-series and time-stratified case-crossover analyses with threshold effects
Li S, Batterman S, Wasilevich E, Wahl R, Wirth J, Su F, Mukherjee B. Association of daily asthma emergency department visits and hospital admissions with ambient air pollutants among the pediatric Medicaid population in Detroit: Time-series and time-stratified case-crossover analyses with threshold effects. Environmental Research 2011, 111: 1137-1147. PMID: 21764049, DOI: 10.1016/j.envres.2011.06.002.Peer-Reviewed Original ResearchConceptsAmbient air pollutionGeneralized additive modelCase-crossover designConditional logistic regressionPediatric Medicaid populationAir pollutionAsthma morbidityAssociated with ambient air pollutionMedicaid populationEffects of air pollutionAsthma emergency department visitsAdditive modelLogistic regressionConditional logistic regression modelsAcute asthma eventsAssociations of SO2Interquartile range increaseCase-crossover analysisEmergency department visitsCase-crossover studyPM2.5 concentrationsPM2.5 thresholdLogistic regression modelsStrong effect sizesPM2.5