Suppression of the host antiviral response by non-infectious varicella zoster virus extracellular vesicles.
Niemeyer C, Frietze S, Coughlan C, Lewis S, Bustos Lopez S, Saviola A, Hansen K, Medina E, Hassell J, Kogut S, Traina-Dorge V, Nagel M, Bruce K, Restrepo D, Mahalingam R, Bubak A. Suppression of the host antiviral response by non-infectious varicella zoster virus extracellular vesicles. Journal Of Virology 2024, e0084824. PMID: 39051773, DOI: 10.1128/jvi.00848-24.Peer-Reviewed Original ResearchVaricella zoster virusVZV pathogenesisVaricella zoster virus infectionSmall extracellular vesiclesZoster virusExtracellular vesiclesSensory neuronsHost antiviral responseHost immune evasion strategyMulti-omics approachHuman sensory neuronsReduce systemic complicationsUnilateral dermatomal distributionVZV-infected neuronsCell-cell contactEvasion strategiesGanglion sensory neuronsType 1 interferon responseSusceptibility to co-infectionImmune-evasion mechanismsImmune evasion strategiesSite of infectionViral spreadHost proteinsBacterial pathogens