Xiaoming Shi
Professor AdjunctCards
About
Research
Publications
2026
High-throughput analytical method for simultaneously detecting pest control agents and specific metabolites in human urine
Fu H, Qiu T, Bao S, Jiang Y, Lu Y, Shi X. High-throughput analytical method for simultaneously detecting pest control agents and specific metabolites in human urine. Microchemical Journal 2026, 224: 117402. DOI: 10.1016/j.microc.2026.117402.Peer-Reviewed Original ResearchSolid-phase extractionHigh-throughput analytical methodMixed-mode solid-phase extractionHuman urineLiquid chromatography-triple quadrupole mass spectrometryCoverage of analytesQuadrupole mass spectrometryPest control agentsMethod detection limitsControl agentsUPLC columnAnalytical methodPH gradient elutionAnalyte coverageDetection limitMass spectrometrySimultaneous quantificationSub-2LC-MS/MSNational human biomonitoring programCo-exposure scenariosPotential health risksHuman biomonitoring programsHuman biological monitoringIsotope dilutionDietary selenium from soil micronutrients and risk of incident type 2 diabetes
Wang F, Sang M, Lü Q, Gu Y, Wu T, Tang Z, Xie W, Qiu S, Yuan Y, Zhou X, Schomburg L, Kopittke P, Shi X, Zhao F, Sun Z, Wang P. Dietary selenium from soil micronutrients and risk of incident type 2 diabetes. Nature Health 2026, 1-15. DOI: 10.1038/s44360-026-00075-4.Peer-Reviewed Original ResearchSoil seleniumAir-quality indicatorsRisk of incident type 2 diabetesSoil micronutrientsHigher risk of incident diabetesRisk of incident diabetesIncident type 2 diabetesHigh riskTrace elementsSoilRisk of metabolic diseasesMetabolic diseasesLevels of serumSerum selenium levelsIncident diabetesEnvironmental geographyDiabetes riskUrinary trace elementsType 2 diabetesLowest tertileCase numbersProspective cohortSeleniumMetabolic outcomesSelenium levelsUrinary nickel and risk of all-cause and neurological mortality in Chinese older adults: Evidence from a prospective cohort study
Wu Y, Chen C, Long F, Ding L, Hu Z, Wei L, Chen Y, Wang L, Qu Y, Shi W, Ji S, Li Y, Chen Y, Yang L, Zhang K, Chen J, Zhou J, Zhao F, Zhu Y, Zhou M, Lv Y, Shi X. Urinary nickel and risk of all-cause and neurological mortality in Chinese older adults: Evidence from a prospective cohort study. Ecotoxicology And Environmental Safety 2026, 313: 119987. PMID: 41806664, DOI: 10.1016/j.ecoenv.2026.119987.Peer-Reviewed Original ResearchConceptsUrinary nickel levelsRestricted cubic splinesNeurological mortalityAll-CauseSubgroup analysisHazard ratioUrinary nickelKaplan-Meier (KM) methodOldest-oldRisk of all-causeOlder adultsCox proportional hazards modelsMortality riskProspective cohort studyConfidence intervalsDose-response analysisRisk of adverse health outcomesAssociated with higher mortality riskDose-response relationshipProportional hazards modelPopulation-based dataNickel exposureChinese older adultsPotential effect modifiersAdverse health outcomes[Association between physical activity and sarcopenia among older adults aged 65 and above in longevity areas of China].
Chen H, Zhao Y, Li Y, Chen C, Meng X, Wang J, Zhou J, Shi W, Zhang Z, Qi L, Chen J, Tan Y, Luo M, Shi X, Lyu Y, Shi W. [Association between physical activity and sarcopenia among older adults aged 65 and above in longevity areas of China]. Chinese Preventive Medicine 2026, 60: 397-406. PMID: 41856626, DOI: 10.3760/cma.j.cn112150-20250806-00770.Peer-Reviewed Original ResearchConceptsPhysical activity scoreTotal physical activityRisk of sarcopeniaRestricted cubic splinesLeisure activity scorePhysical activityRestricted cubic spline analysisPrevalence of sarcopeniaSarcopenia riskMultivariate logistic regression analysisLogistic regression analysisLongevity areasOlder adultsScore of physical activityTotal physical activity scoreExposure-response relationshipInactive groupHousehold physical activityPhysical Activity ScaleLeisure physical activityPhysical activity groupResults:Activity scoreActive groupLeisure-time activitiesGenetic variations interact with polybrominated diphenyl ether exposure to alter lipid homeostasis
Hu N, Li B, Lu Y, Jiang Q, Zhu Y, Li Z, Qu Y, Qiu T, Zhang D, Wang Z, Ma Y, Jin H, Sun P, Song H, Zhao Y, Zhao Y, Zhang M, Zhao F, Ji S, Yuan B, Zhu Y, Lv Y, Tian J, Miao X, Shi X. Genetic variations interact with polybrominated diphenyl ether exposure to alter lipid homeostasis. Nature Communications 2026 PMID: 41786719, DOI: 10.1038/s41467-026-70222-8.Peer-Reviewed Original ResearchGenetic variantsMolecular basisEther exposurePolygenic risk scoresGenetic variationLipid homeostasisFunctional validationCRISPR/Cas9 editingPolybrominated Diphenyl EthersDyslipidemia riskPolybrominated diphenyl ether exposureLipid metabolismMetabolomics dataCholesterol accumulationMetabolomic analysisGene-environment interaction mechanismsGlycine transportRisk scoreDyslipidemiaVariantsGlycineAdvancing a new generation of heat-health warning system in China
Li T, Ma R, Wang Q, Zhang T, Chen H, Wang L, Shi X, Shen H. Advancing a new generation of heat-health warning system in China. Nature Medicine 2026, 1-2. PMID: 41781547, DOI: 10.1038/s41591-026-04240-w.Peer-Reviewed Original ResearchIntegrating Urban Wastewater Surveillance and Internet Search Behavior to Strengthen Early Warning for Infectious Diseases
Deng F, Xu H, Fu S, Yao Q, Qin J, Yang C, Yao Y, Li P, Tian W, Wang X, Lv L, Xia X, Lin X, Zhang R, Guo Z, Xiong L, Peng S, Ding Z, Chen C, Wang Y, Ding E, Zhao X, Hao D, Zhu H, Duan S, Li S, Sun M, Li X, Huang J, Zhang X, Zhang L, Sun H, Hao S, Han J, Liu Y, Zhang L, Yao X, Jiang G, Zhang T, Ji J, Tang S, Xu B, Shen H, Shi X. Integrating Urban Wastewater Surveillance and Internet Search Behavior to Strengthen Early Warning for Infectious Diseases. Engineering 2026 DOI: 10.1016/j.eng.2026.02.022.Peer-Reviewed Original ResearchDevelopment and validation of a method for determinion of organophosphorus flame retardant di-ester and hydroxylated metabolites in human urine
Yu X, Qiu T, Wang J, Luo Q, Shen T, Lu Y, Shi X. Development and validation of a method for determinion of organophosphorus flame retardant di-ester and hydroxylated metabolites in human urine. Analytica Chimica Acta 2026, 1394: 345224. PMID: 41730594, DOI: 10.1016/j.aca.2026.345224.Peer-Reviewed Original ResearchConceptsBaseline separationSeparation of isomeric compoundsMultiple reaction monitoring modeHuman urineHigh-throughput liquid chromatography-tandem mass spectrometryReaction monitoring modeIon fragmentation patternsMass spectrometry settingsHydroxylated metabolitesSolid-phase extractionMethod detection limitsSample preparation procedureLiquid chromatography-tandem mass spectrometryOrganophosphate flame retardantsChromatography-tandem mass spectrometryElectrospray ionizationIsomeric compoundsMonitoring modeMethanol solutionChromatographic parametersFragmentation patternsMobile phaseMatrix effectsElution strengthDetection limitNeighborhood Greenspace Enhances Cardiopulmonary Function in Healthy Older Adults: A Multiomics Analysis from the BAPE Study
Zhou W, Gao J, Guo X, Xu J, Shi W, Wang Y, Cha Y, Tang S, Shi X, Ji J. Neighborhood Greenspace Enhances Cardiopulmonary Function in Healthy Older Adults: A Multiomics Analysis from the BAPE Study. Environment & Health 2026 DOI: 10.1021/envhealth.5c00637.Peer-Reviewed Original ResearchOlder adultsGreenspace exposureHealthy older adultsParticipating residentsForced Vital CapacityPopulation health benefitsInterquartile rangeGreenness exposureLinear mixed-effects modelsRepeated-measures panel studyRespiratory healthMixed-effects modelsCardiopulmonary outcomesHealth benefitsAdultsCardiopulmonary functionCardiovascular outcomesVital capacityClinical examinationMultiomics analysisMonthly clinical examinationNitric oxide metabolismPulmonary functionMultiomic profilingPanel StudyExposure to Per- and Polyfluoroalkyl Substances and Abnormal Glycometabolism in Healthy Elderly: Multiomics Evidence from the China BAPE Study
Zhang J, Sun P, Ren H, Guo X, Ding E, Ma X, Li C, Li C, Xu Y, Cao K, Qian J, Qi C, Situ Y, Tong S, Lu X, Tang S, Shi X. Exposure to Per- and Polyfluoroalkyl Substances and Abnormal Glycometabolism in Healthy Elderly: Multiomics Evidence from the China BAPE Study. Environmental Science And Technology 2026, 60: 4171-4183. PMID: 41591335, DOI: 10.1021/acs.est.5c12999.Peer-Reviewed Original ResearchConceptsBayesian kernel machine regressionGlycated serum proteinAssociated with increasesType 2 diabetes mellitusPolyfluoroalkyl substances exposuresTriglyceride-glucose indexMultiomics analysisExposure to perfluorodecanoic acidLinear mixed-effects modelsIntegrative multiomic analysisAbnormal glycometabolismManaging type 2 diabetes mellitusPublic health strategiesBlood concentrationsExposure to polyfluoroalkyl substancesMetabolic disruptionPFAS mixtureBayesian kernel machine regression modelsElderly populationKernel machine regressionPolyfluoroalkyl substancesMarkersCanonical pathwaysMixed-effects modelsPerfluorodecanoic acid