2023
Prediabetes and Associated Risk of Cardiovascular Events and Chronic Kidney Disease Among Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort
Dixon S, Wang F, Lu L, Wilson C, Green D, Merchant T, Srivastava D, Delaney A, Howell R, Jefferies J, Robison L, Ness K, Hudson M, Chemaitilly W, Armstrong G. Prediabetes and Associated Risk of Cardiovascular Events and Chronic Kidney Disease Among Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort. Journal Of Clinical Oncology 2023, 42: 1031-1043. PMID: 38091552, PMCID: PMC10950176, DOI: 10.1200/jco.23.01005.Peer-Reviewed Original ResearchConceptsChronic kidney diseasePrevalence of prediabetesRisk of cardiovascular eventsAdult survivors of childhood cancerSurvivors of childhood cancerIncreased riskCardiovascular eventsKidney diseaseRisk of future cardiac eventsAssociated with radiation exposureTotal body irradiationRisk of progressionChildhood cancerCox proportional hazards regressionSt Jude Lifetime CohortFuture cardiac eventsPrevent subsequent morbidityProportional hazards regressionModifiable risk factorsNormal glucose controlAdult survivorsLongitudinal follow-upChildhood cancer diagnosisPrediabetes to diabetesMedian ageAccumulation of Chronic Disease Among Survivors of Childhood Cancer Predicts Early Mortality
Esbenshade A, Lu L, Friedman D, Oeffinger K, Armstrong G, Krull K, Neglia J, Leisenring W, Howell R, Partin R, Sketch A, Robison L, Ness K. Accumulation of Chronic Disease Among Survivors of Childhood Cancer Predicts Early Mortality. Journal Of Clinical Oncology 2023, 41: 3629-3641. PMID: 37216619, PMCID: PMC10325751, DOI: 10.1200/jco.22.02240.Peer-Reviewed Original ResearchConceptsBaseline total scoreCancer survivorsTotal scoreMedian ageChildhood cancerCumulative Illness Rating ScaleCox proportional hazards regressionRating ScaleAccumulation of comorbiditiesCIRS-G scoreTreatment-related morbidityIllness Rating ScaleProportional hazards regressionNutrition Examination SurveyStudy cohort membersYoung adult survivorsSubsequent mortality riskGeriatric Rating ScaleNHANES populationHazards regressionEarly mortalityExamination SurveySeverity scoreNational HealthCohort members
2021
Clinicopathologic characteristics and oncologic outcomes in adenosarcoma of gynecologic sites
Li JY, Mutlu L, Tymon-Rosario J, Khadraoui W, Nagarkatti N, Hui P, Buza N, Lu L, Schwartz P, Menderes G. Clinicopathologic characteristics and oncologic outcomes in adenosarcoma of gynecologic sites. Gynecologic Oncology Reports 2021, 39: 100913. PMID: 35005157, PMCID: PMC8715286, DOI: 10.1016/j.gore.2021.100913.Peer-Reviewed Original ResearchRecurrence-free survivalEarly-stage diseaseHigh-grade histologyOvarian preservationNode dissectionGrade histologyOncologic outcomesOverall survivalClinicopathologic characteristicsMyometrial invasionSarcomatous overgrowthPatients underwent lymph node dissectionUnderwent lymph node dissectionCox proportional hazards regressionLymph node dissectionEvidence of diseaseNon-inferior outcomesDeep myometrial invasionProportional hazards regressionLog-rank testKaplan-Meier estimatesLarge patient cohortPractical management optionsBilateral adnexectomyCervical adenosarcoma