Kendra Plourde, PhD
Assistant Professor of BiostatisticsCards
About
Research
Publications
2024
A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials.
Tong G, Nevins P, Ryan M, Davis-Plourde K, Ouyang Y, Pereira Macedo J, Meng C, Wang X, Caille A, Li F, Taljaard M. A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials. Clinical Trials 2024, 17407745241276137. PMID: 39377196, DOI: 10.1177/17407745241276137.Peer-Reviewed Original ResearchSmall-sample correctionsStepped-wedge cluster randomized trialCluster randomized trialSample size calculation methodGeneralized linear mixed modelsLongitudinal correlation structureSize calculation methodLinear mixed modelsPermutation testSample sizeBayesian approachRandomized trialsCorrelation structureMixed modelsBayesian analysisGeneralized estimating equationsPermutationMedian sample sizeIntervention conditionRandomization methodEquationsNational Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults
Wang Y, Leo-Summers L, Vander Wyk B, Davis-Plourde K, Gill T, Becher R. National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults. JAMA Network Open 2024, 7: e240028. PMID: 38416499, PMCID: PMC10902728, DOI: 10.1001/jamanetworkopen.2024.0028.Peer-Reviewed Original ResearchConceptsCenters for Medicare & Medicaid ServicesFee-for-serviceMedicare Advantage beneficiariesHospital readmissionUS residentsNational Health and Aging Trends Study dataCommunity-living older adultsProspective longitudinal cohort studyCommunity-living participantsRate of hospital readmissionLikelihood of hospital readmissionPopulation-based estimatesNationally representative estimatesSex-adjusted modelsCommunity-livingData linkageGeriatric conditionsMedicaid ServicesOlder personsOlder adultsMain OutcomesNational estimatesRepresentative estimatesData analysisCohort study
2023
Adherence to key recommendations for design and analysis of stepped-wedge cluster randomized trials: A review of trials published 2016–2022
Nevins P, Ryan M, Davis-Plourde K, Ouyang Y, Macedo J, Meng C, Tong G, Wang X, Ortiz-Reyes L, Caille A, Li F, Taljaard M. Adherence to key recommendations for design and analysis of stepped-wedge cluster randomized trials: A review of trials published 2016–2022. Clinical Trials 2023, 21: 199-210. PMID: 37990575, PMCID: PMC11003836, DOI: 10.1177/17407745231208397.Peer-Reviewed Original ResearchAssessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US
Festa N, Throgmorton K, Davis-Plourde K, Dosa D, Chen K, Zang E, Kelly J, Gill T. Assessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US. JAMA Network Open 2023, 6: e2320207. PMID: 37358851, PMCID: PMC10293909, DOI: 10.1001/jamanetworkopen.2023.20207.Peer-Reviewed Original ResearchConceptsCross-sectional studyNursing homesNursing home characteristicsMean survival timeUS nursing homesGreater mean numberPrimary outcomeUS CentersExposure statusMAIN OUTCOMEElevated riskSurvival timeSurvival analysisPresence of deficienciesMore deficienciesRisk statusEmergency preparednessHome characteristicsMean numberRiskPreparedness standardsDeficiencyResponsivenessHigh percentageOutcomesA scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials
Nevins P, Davis-Plourde K, Pereira Macedo J, Ouyang Y, Ryan M, Tong G, Wang X, Meng C, Ortiz-Reyes L, Li F, Caille A, Taljaard M. A scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials. Journal Of Clinical Epidemiology 2023, 157: 134-145. PMID: 36931478, PMCID: PMC10546924, DOI: 10.1016/j.jclinepi.2023.03.010.Peer-Reviewed Original ResearchConceptsStepped-wedge clusterIndividual-level characteristicsMethod of randomizationCross-sectional designControl armBaseline imbalancesCohort designMedian numberElectronic searchPrimary analysisBaseline balanceStudy designPrimary reportsBaselineTrialsIntervention conditionSW-CRTsRandomizationReporting
2022
Power analyses for stepped wedge designs with multivariate continuous outcomes
Davis‐Plourde K, Taljaard M, Li F. Power analyses for stepped wedge designs with multivariate continuous outcomes. Statistics In Medicine 2022, 42: 559-578. PMID: 36565050, PMCID: PMC9985483, DOI: 10.1002/sim.9632.Peer-Reviewed Original ResearchConceptsMultivariate outcomesMultivariate linear mixed modelIntracluster correlation coefficientSample size proceduresClosed cohort designRigorous justificationSample size calculation procedureTreatment effect estimatorJoint distributionSize proceduresTest statisticLinear mixed modelsEfficient treatment effect estimatorsCommon treatment effectMixed modelsCalculation procedureExtensive simulationsEffects estimatorIntersection-union testPower analysisEstimatorWedge designEfficient powerModelContinuous outcomesNon-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-β and Tau Pathology in Middle-Aged Adults: The Framingham Study
Weinstein G, O’Donnell A, Davis-Plourde K, Zelber-Sagi S, Ghosh S, DeCarli CS, Thibault EG, Sperling RA, Johnson KA, Beiser AS, Seshadri S. Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-β and Tau Pathology in Middle-Aged Adults: The Framingham Study. Journal Of Alzheimer's Disease 2022, 86: 1371-1383. PMID: 35213373, PMCID: PMC11323287, DOI: 10.3233/jad-215409.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseasePrevalent non-alcoholic fatty liver diseaseFIB-4 indexFatty liver diseaseAlzheimer's disease pathologyFIB-4Liver fibrosisDisease pathologyAdvanced fibrosisLiver diseaseTau pathologyRisk factorsRelationship of NAFLDTau positron emission tomography (PET) imagingEarly Alzheimer's disease pathologyCardio-metabolic risk factorsAlcoholic fatty liver diseaseThird Generation cohortsFramingham Study participantsNon-invasive indexPositron emission tomography (PET) imagingEmission Tomography ImagingMiddle-aged adultsRegional tauLiver steatosisJoint Models for Estimating Determinants of Cognitive Decline in the Presence of Survival Bias
Davis-Plourde KL, Mayeda ER, Lodi S, Filshtein T, Beiser A, Gross AL, Seshadri S, Glymour MM, Tripodis Y. Joint Models for Estimating Determinants of Cognitive Decline in the Presence of Survival Bias. Epidemiology 2022, 33: 362-371. PMID: 35383644, DOI: 10.1097/ede.0000000000001472.Peer-Reviewed Original ResearchConceptsCognitive declineSurvival biasCox proportional hazards modelHazard of mortalityProportional hazards modelExposure of interestEffect of educationEffects of exposureHazards modelDementia diagnosisAlzheimer's diseaseMixed-effects modelsGEE modelMortalitySurvivalInconsistent resultsDiseaseInformative attritionStudy dataAttrition weightsExposure
2021
Sample Size Considerations for Stepped Wedge Designs with Subclusters
Davis-Plourde K, Taljaard M, Li F. Sample Size Considerations for Stepped Wedge Designs with Subclusters. Biometrics 2021, 79: 98-112. PMID: 34719017, PMCID: PMC9054939, DOI: 10.1111/biom.13596.Peer-Reviewed Original ResearchCoronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study
Suzuki H, Davis-Plourde K, Beiser A, Kunimura A, Miura K, DeCarli C, Maillard P, Mitchell GF, Vasan RS, Seshadri S, Fujiyoshi A. Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study. Circulation Cardiovascular Imaging 2021, 14: e011753. PMID: 34256573, PMCID: PMC8323993, DOI: 10.1161/circimaging.120.011753.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAsymptomatic DiseasesCoronary AngiographyCoronary Artery DiseaseDiffusion Tensor ImagingFemaleHumansLeukoencephalopathiesMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsSex FactorsTime FactorsVascular CalcificationConceptsCoronary artery calciumWhite matter injurySubtle white matter injuryAsymptomatic middle-aged menCAC scoreMiddle-aged menFractional anisotropyCAC groupDiffusion tensor imaging-based measuresCarotid-femoral pulse wave velocityLog-transformed CAC scoreSecondary analysisBrain magnetic resonance imagingPredictors of strokePulse wave velocityCross-sectional associationsMagnetic resonance diffusion tensorImaging-based measuresMagnetic resonance imagingLower fractional anisotropyFramingham Heart StudyMiddle-age adultsArtery calciumMultivariable adjustmentAortic stiffness