2020
Impaired Hematological Status Increases the Risk of Mortality among HIV-Infected Adults Initiating Antiretroviral Therapy in Tanzania
Noor RA, Abioye AI, Hertzmark E, Darling AM, Aboud S, Mugusi FM, Sudfeld CR, Spiegelman D, Fawzi WW. Impaired Hematological Status Increases the Risk of Mortality among HIV-Infected Adults Initiating Antiretroviral Therapy in Tanzania. Journal Of Nutrition 2020, 150: 2375-2382. PMID: 32621487, PMCID: PMC7540061, DOI: 10.1093/jn/nxaa172.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCohort StudiesFemaleHIV InfectionsHumansMaleMiddle AgedRisk FactorsTanzaniaConceptsRisk of mortalityPrevalence of anemiaHAART initiationHematological statusIron deficiencyAntiretroviral therapySerum ferritinSevere anemiaIncident clinical outcomesRelation of anemiaTrial of multivitaminsActive antiretroviral therapyHIV disease progressionCase-cohort studyIron deficiency anemiaProportional hazards modelElevated ironNonanemic participantsHIV patientsMultivariate adjustmentClinical outcomesMorbidity outcomesAnemia etiologyDeficiency anemiaIron supplementation
2005
Insulin Resistance in HIV-Infected Men and Women in the Nutrition for Healthy Living Cohort
Jones CY, Wilson IB, Greenberg AS, Shevitz A, Knox TA, Gorbach SL, Spiegelman D, Jacobson DL, Wanke C. Insulin Resistance in HIV-Infected Men and Women in the Nutrition for Healthy Living Cohort. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 40: 202-211. PMID: 16186739, DOI: 10.1097/01.qai.0000165910.89462.2f.Peer-Reviewed Original ResearchMeSH KeywordsAntiretroviral Therapy, Highly ActiveBody CompositionCohort StudiesCross-Sectional StudiesFemaleHIV InfectionsHumansInsulin ResistanceLife StyleLongitudinal StudiesMaleNutritional Physiological PhenomenaConceptsQuantitative insulin sensitivity check indexWorse insulin resistancePrevalence of IRInsulin resistanceNHANES IIIHigher high-density lipoproteinInsulin sensitivity check indexNutrition Examination Survey IIIHealthy Living cohortHealthy Living StudyHIV-Infected MenMore insulin resistanceActive antiretroviral therapyCD4 cell countCross-sectional study designInjection drug useLess insulin resistanceExamination Survey IIINHANES III participantsGreater waist circumferenceHigh-density lipoproteinLow-density lipoproteinProtease inhibitorsLiving cohortPI-HAARTIncreasing Risk of 5% or Greater Unintentional Weight Loss in a Cohort of HIV-Infected Patients, 1995 to 2003
Tang AM, Jacobson DL, Spiegelman D, Knox TA, Wanke C. Increasing Risk of 5% or Greater Unintentional Weight Loss in a Cohort of HIV-Infected Patients, 1995 to 2003. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 40: 70-76. PMID: 16123685, DOI: 10.1097/01.qai.0000159627.54149.2e.Peer-Reviewed Original ResearchConceptsCohort of HIVUnintentional weight lossWeight lossAntiretroviral therapyBody compositionLow CD4 cell countsHigher HIV viral loadHigher body mass indexCare of HIVHealthy Living cohortActive antiretroviral therapyCD4 cell countCombination antiretroviral therapyHIV viral loadBody mass indexRisk of deathPresence of diarrheaFederal poverty levelLiving cohortHIV infectionMass indexMost AIDSOpportunistic infectionsViral loadPatient populationPredictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children
Jacobson DL, Spiegelman D, Duggan C, Weinberg GA, Bechard L, Furuta L, Nicchitta J, Gorbach SL, Miller TL. Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children. Journal Of Pediatric Gastroenterology And Nutrition 2005, 41: 339-346. PMID: 16131991, DOI: 10.1097/01.mpg.0000174468.75219.30.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAntiretroviral Therapy, Highly ActiveBlack or African AmericanBody CompositionBody HeightBody Mass IndexBody WeightBone DensityCase-Control StudiesChildChild DevelopmentCross-Sectional StudiesFemaleHispanic or LatinoHIV InfectionsHIV-1HumansLongitudinal StudiesMalePredictive Value of TestsProspective StudiesSeverity of Illness IndexVitaminsWhite PeopleConceptsBMD Z-scoresBone mineral densityLower BMD Z-scoresMineral densityZ-scorePopulation normsMultivitamin useDietary intakePredictors of BMDTotal body bone mineral densityLower weight z-scoreBody bone mineral densityLow bone mineral densitySibling controlsBetter bone mineral densityDual-energy X-ray absorptiometry (DXA) examinationDual-energy X-ray absorptiometryLower height Z-scoresHuman immunodeficiency virus-1Energy X-ray absorptiometryAdvanced HIV stageAge-adjusted percentileIndependent risk factorGender-adjusted z-scoresWeight z-scoreA Comparison of the Clinical and Cost-Effectiveness of 3 Intervention Strategies for AIDS Wasting
Shevitz AH, Wilson IB, McDermott AY, Spiegelman D, Skinner SC, Antonsson K, Layne JE, Beaston-Blaakman A, Shepard DS, Gorbach SL. A Comparison of the Clinical and Cost-Effectiveness of 3 Intervention Strategies for AIDS Wasting. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 38: 399-406. PMID: 15764956, DOI: 10.1097/01.qai.0000152647.89008.2b.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnabolic AgentsAntiretroviral Therapy, Highly ActiveBody CompositionCost-Benefit AnalysisDietFemaleHealth StatusHIV Wasting SyndromeHumansMaleMassachusettsMiddle AgedMuscle, SkeletalNutritional Physiological PhenomenaOxandrolonePhysical Education and TrainingQuality of LifeTreatment OutcomeConceptsProgressive resistance trainingCross-sectional muscle areaPhysical functioningCost-effective interventionAIDS wastingLeast cost-effective interventionBaseline physical functioningQuality of lifeInstitutional costsPlacebo pillsResistance trainingCaloric intakeProtein intakeBody compositionStrength training
2004
Understanding the Role of HIV Load in Determining Weight Change in the Era of Highly Active Antiretroviral Therapy
Mwamburi DM, Wilson IB, Jacobson DL, Spiegelman D, Gorbach SL, Knox TA, Wanke CA. Understanding the Role of HIV Load in Determining Weight Change in the Era of Highly Active Antiretroviral Therapy. Clinical Infectious Diseases 2004, 40: 167-173. PMID: 15614708, DOI: 10.1086/426591.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBody WeightCD4 Lymphocyte CountFemaleHIVHIV InfectionsHumansRNA, ViralViral LoadConceptsActive antiretroviral therapyVirus loadBody weightAntiretroviral therapyHIV infectionWeight changeStudy visitHuman immunodeficiency virus RNA loadHighly Active Antiretroviral TherapyAbsence of HAARTProspective cohort studyCell count decreaseVirus RNA loadTime of enrollmentStudy intervalRepeated-measures analysisHIV loadHAART useCohort studyRNA loadHAARTPatientsEligible sampleCell countCount decrease
2003
Difficulty Swallowing and Lack of Receipt of Highly Active Antiretroviral Therapy Predict Acute Weight Loss in Human Immunodeficiency Virus Disease
Jacobson DL, Bica I, Knox TA, Wanke C, Tchetgen E, Spiegelman D, Silva M, Gorbach S, Wilson IB. Difficulty Swallowing and Lack of Receipt of Highly Active Antiretroviral Therapy Predict Acute Weight Loss in Human Immunodeficiency Virus Disease. Clinical Infectious Diseases 2003, 37: 1349-1356. PMID: 14583869, DOI: 10.1086/379072.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveFemaleHIV InfectionsHumansMaleRiskWeight LossConceptsAcute weight lossHuman immunodeficiency virus (HIV) diseaseOral symptomsWeight lossLack of receiptActive antiretroviral therapyUpper respiratory symptomsVirus diseaseTrouble swallowingAbdominal painAntiretroviral therapyRespiratory symptomsDifficulty swallowingNutrient malabsorptionSkin symptomsCommon symptomsRecent symptomsCaloric intakeSymptom complexSymptomsWeight changeDiarrheaMetabolic needsSwallowingDiseaseUse of Complementary and Alternative Therapies by Patients With Human Immunodeficiency Virus Disease in the Era of Highly Active Antiretroviral Therapy
Bica I, Tang AM, Skinner S, Spiegelman D, Knox T, Gorbach S, Wilson IB. Use of Complementary and Alternative Therapies by Patients With Human Immunodeficiency Virus Disease in the Era of Highly Active Antiretroviral Therapy. Journal Of Alternative And Complementary Medicine 2003, 9: 65-76. PMID: 12676036, DOI: 10.1089/107555303321222955.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusActive antiretroviral therapyCAM useAntiretroviral therapyHighly Active Antiretroviral TherapyHuman immunodeficiency virus (HIV) diseaseCAM therapy useHealthy Living StudyPotential drug interactionsUse of ComplementaryLow-risk groupAlternative medical therapiesEffective drug treatmentCross-sectional analysisLeast high schoolHAART useCohort studyMale patientsMedical therapyTherapy useImmunodeficiency virusComplementary therapiesAlternative therapiesStudy visitRisk groups
2002
Weight loss and body-composition changes in men and women infected with HIV 1 , 2 , 3
Forrester JE, Spiegelman D, Tchetgen E, Knox TA, Gorbach SL. Weight loss and body-composition changes in men and women infected with HIV 1 , 2 , 3. American Journal Of Clinical Nutrition 2002, 76: 1428-1434. PMID: 12450913, DOI: 10.1093/ajcn/76.6.1428.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAntiretroviral Therapy, Highly ActiveBody CompositionElectric ImpedanceFemaleHIV InfectionsHumansMaleSex CharacteristicsWeight LossWeight Loss and Survival in HIV-Positive Patients in the Era of Highly Active Antiretroviral Therapy
Tang AM, Forrester J, Spiegelman D, Knox TA, Tchetgen E, Gorbach SL. Weight Loss and Survival in HIV-Positive Patients in the Era of Highly Active Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2002, 31: 230-236. PMID: 12394802, DOI: 10.1097/01.qai.0000026514.98625.8f.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBody Mass IndexBostonCohort StudiesElectric ImpedanceFemaleHIV InfectionsHIV Wasting SyndromeHumansMaleMiddle AgedPredictive Value of TestsPrognosisSurvival AnalysisWeight LossConceptsActive antiretroviral therapyWeight lossAntiretroviral therapyHAART useIndependent predictorsPrevious visitHighly Active Antiretroviral TherapyHealthy Living StudyCD4 cell countHIV-positive patientsHIV-positive participantsBody mass indexStrong independent predictorFurther prognostic valueProportional hazards modelBioelectrical impedance analysisFour- to sixfold increaseImportant comorbidityMass indexPrognostic valuePotential confoundersRelative riskStudy populationLiving StudyHazards modelRole of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men
Roubenoff R, Grinspoon S, Skolnik PR, Tchetgen E, Abad L, Spiegelman D, Knox T, Gorbach S. Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men. AJP Endocrinology And Metabolism 2002, 283: e138-e145. PMID: 12067854, DOI: 10.1152/ajpendo.00426.2001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntiretroviral Therapy, Highly ActiveBody CompositionBody WeightCD4 Lymphocyte CountCytokinesEnergy MetabolismFollow-Up StudiesHIV InfectionsHIV Wasting SyndromeHumansInterleukin-1Linear ModelsLongitudinal StudiesMaleMiddle AgedNutritional StatusRestTestosteroneThinnessTumor Necrosis Factor-alphaViral LoadConceptsLBM lossPeripheral blood mononuclear cellsIL-1 beta productionWeight lossActive antiretroviral therapyCohort of patientsSerum free testosteroneBlood mononuclear cellsInadequate dietary intakeOngoing cohort studyCytokine tumor necrosisRole of cytokinesIL-1 betaTNF-alpha productionInterleukin-1 betaMo of observationLean body massKcal/dayAntiretroviral therapyCohort studyFree testosteroneHIV infectionIndependent predictorsCytokine productionMononuclear cells
2001
Patterns of Adherence With Antiretroviral Medications: An Examination of Between-Medication Differences.
Wilson IB, Tchetgen E, Spiegelman D. Patterns of Adherence With Antiretroviral Medications: An Examination of Between-Medication Differences. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2001, 28: 259. PMID: 11694833, DOI: 10.1097/00042560-200111010-00009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntiretroviral Therapy, Highly ActiveCohort StudiesCross-Sectional StudiesFemaleHIV InfectionsHumansMaleMiddle AgedPatient ComplianceConceptsAntiretroviral medicationsAdherence issuesPatient differencesLast weekMore antiretroviral medicationsPercent of patientsPatterns of adherencePatient adherence issuesRepeated-measurements analysisCohort studyHIV infectionAntiretroviral adherenceAdherence ratesMean ageOverall adherenceMedicationsPatientsAdherence patternsPerfect adherencePerson varianceDosing timeAdherenceWeeksDoseReliability coefficients
2000
Diarrhea and abnormalities of gastrointestinal function in a cohort of men and women with HIV infection
Knox T, Spiegelman D, Skinner S, Gorbach S. Diarrhea and abnormalities of gastrointestinal function in a cohort of men and women with HIV infection. The American Journal Of Gastroenterology 2000, 95: ajg20001597. PMID: 11151881, DOI: 10.1111/j.1572-0241.2000.03365.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntiretroviral Therapy, Highly ActiveCohort StudiesCross-Sectional StudiesDietDigestive SystemFemaleHIV EnteropathyHumansMaleNutritional StatusPrevalenceSex FactorsSubstance Abuse, IntravenousConceptsIntravenous drug usersD-xylose absorptionLow D-xylose absorptionVitamin B12 levelsGastrointestinal functionHIV infectionLiver diseaseStool pathogensGastrointestinal dysfunctionB12 levelsLow serum vitamin B12 levelsLow vitamin B12 levelsSerum vitamin B12 levelsSeverity of immunosuppressionSudan III stainCells/mm3D-xylose testAbsence of diarrheaCohort of menAdvanced immunosuppressionCurrent diarrheaChronic diarrheaSerum levelsHIV treatmentFat diet