2024
Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors
Goggin K, Lu L, Lee D, Howell C, Srivastava D, Brinkman T, Armstrong G, Bhakta N, Robison L, Ehrhardt M, Hudson M, Krull K, Pui C, Rubnitz J, Ness K, Wolf J. Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors. JAMA Network Open 2024, 7: e242727. PMID: 38497960, PMCID: PMC10949094, DOI: 10.1001/jamanetworkopen.2024.2727.Peer-Reviewed Original ResearchConceptsChronic health conditionsHealth conditionsAdult survivorsCohort studyAdult survivors of childhood cancerSt Jude Lifetime Cohort StudyIncidence of chronic health conditionsChildhood leukemiaSurvivors of childhood cancerAssociated with long-term riskIncreased riskMedical record reviewQuality of lifeInverse propensity score weightingAdult survivors of childhood leukemiaYear of diagnosisCancer survivorsSevere sepsisPropensity score weightingSurvivors of childhood leukemiaMain OutcomesPotential confoundersChildhood cancerRecord reviewLong-term risk
2023
Prediabetes and Associated Risk of Cardiovascular Events and Chronic Kidney Disease Among Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort
Dixon S, Wang F, Lu L, Wilson C, Green D, Merchant T, Srivastava D, Delaney A, Howell R, Jefferies J, Robison L, Ness K, Hudson M, Chemaitilly W, Armstrong G. Prediabetes and Associated Risk of Cardiovascular Events and Chronic Kidney Disease Among Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort. Journal Of Clinical Oncology 2023, 42: 1031-1043. PMID: 38091552, PMCID: PMC10950176, DOI: 10.1200/jco.23.01005.Peer-Reviewed Original ResearchConceptsChronic kidney diseasePrevalence of prediabetesRisk of cardiovascular eventsAdult survivors of childhood cancerSurvivors of childhood cancerIncreased riskCardiovascular eventsKidney diseaseRisk of future cardiac eventsAssociated with radiation exposureTotal body irradiationRisk of progressionChildhood cancerCox proportional hazards regressionSt Jude Lifetime CohortFuture cardiac eventsPrevent subsequent morbidityProportional hazards regressionModifiable risk factorsNormal glucose controlAdult survivorsLongitudinal follow-upChildhood cancer diagnosisPrediabetes to diabetesMedian ageAccumulation of Chronic Disease Among Survivors of Childhood Cancer Predicts Early Mortality
Esbenshade A, Lu L, Friedman D, Oeffinger K, Armstrong G, Krull K, Neglia J, Leisenring W, Howell R, Partin R, Sketch A, Robison L, Ness K. Accumulation of Chronic Disease Among Survivors of Childhood Cancer Predicts Early Mortality. Journal Of Clinical Oncology 2023, 41: 3629-3641. PMID: 37216619, PMCID: PMC10325751, DOI: 10.1200/jco.22.02240.Peer-Reviewed Original ResearchMeSH KeywordsCancer SurvivorsChildChronic DiseaseFemaleHumansMaleNeoplasmsNutrition SurveysSiblingsSurvivorsConceptsBaseline total scoreCancer survivorsTotal scoreMedian ageChildhood cancerCumulative Illness Rating ScaleCox proportional hazards regressionRating ScaleAccumulation of comorbiditiesCIRS-G scoreTreatment-related morbidityIllness Rating ScaleProportional hazards regressionNutrition Examination SurveyStudy cohort membersYoung adult survivorsSubsequent mortality riskGeriatric Rating ScaleNHANES populationHazards regressionEarly mortalityExamination SurveySeverity scoreNational HealthCohort members
2018
Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
Sanft T, Usiskin I, Harrigan M, Cartmel B, Lu L, Li FY, Zhou Y, Chagpar A, Ferrucci LM, Pusztai L, Irwin ML. Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study. Breast Cancer Research And Treatment 2018, 172: 105-112. PMID: 30062572, DOI: 10.1007/s10549-018-4895-7.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsWeight loss interventionUsual care groupBody mass indexBreast cancer riskCancer survivorsUsual careLoss interventionBreast cancerStage 0Quantitative polymerase chain reactionCare groupTelomere lengthCancer riskStage II/III breast cancerObese breast cancer survivorsWeight lossI breast cancerNon-Hispanic whitesPurposeSome studiesMass indexIntervention groupPhysical activityBlood samplesConclusionOur findings
2011
Risk of second primary cancer after treatment for esophageal cancer: a pooled analysis of nine cancer registries
Zhu G, Chen Y, Zhu Z, Lu L, Bi X, Deng Q, Chen X, Su H, Liu Y, Guo H, Zheng T, Yu H, Zhang Y. Risk of second primary cancer after treatment for esophageal cancer: a pooled analysis of nine cancer registries. Diseases Of The Esophagus 2011, 25: 505-511. PMID: 22067063, DOI: 10.1111/j.1442-2050.2011.01273.x.Peer-Reviewed Original ResearchConceptsStandardized incidence ratiosEsophageal cancer survivorsSecond primary cancerSecond cancersEsophageal cancerPrimary cancerCancer survivorsProstate cancerCancer riskEnd Results ProgramEsophageal cancer patientsAssociation of radiotherapySecond cancer riskMost risk estimatesCancer RegistryIncidence ratiosDecreased riskPatient survivalResults ProgramPooled analysisCancer patientsLung cancerClinical trialsSecondary cancersGeneral population