2018
D-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer
Yu X, Lin H, Wang Y, Lv W, Zhang S, Qian Y, Deng X, Feng N, Yu H, Qian B. D-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer. OncoTargets And Therapy 2018, 11: 1833-1847. PMID: 29670359, PMCID: PMC5894671, DOI: 10.2147/ott.s155716.Peer-Reviewed Original ResearchLung cancer cellsLung cancerCancer cellsTherapeutic effectUse of chloroquineXenograft animal modelCell Counting Kit-8Real-time quantitative polymerase chain reactionCounting Kit-8Flow cytometric analysisQuantitative polymerase chain reactionMechanism of actionExpression of apoptosisPolymerase chain reactionApoptosis-related gene expressionAnimal modelsNude miceCytometric analysisKit-8Western blotAutophagy markersAutophagy inhibitorCancerAntitumor activityProapoptotic effects
2003
Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk
Wu X, Yu H, Makan N, Spitz M. Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk. Methods In Molecular Medicine 2003, 75: 279-287. PMID: 12407747, DOI: 10.1385/1-59259-324-0:279.Peer-Reviewed Original ResearchMeSH Keywords7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideBleomycinChromatidsChromosome AberrationsEnzyme-Linked Immunosorbent AssayHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IILung NeoplasmsLymphocytesMutagenicity TestsMutagensPredictive Value of TestsRisk FactorsConceptsInsulin-like growth factorSignal transduction pathwaysGrowth factorCell cycle progressionCell membrane receptorsTransduction pathwaysBcl proteinsMAP kinaseLung cancer cellsIGF-1 receptorCell deathMembrane receptorsS phaseAntiproliferative moleculesBinding of IGFBax proteinCell proliferationLung cancer riskImportant functionsProteinCancer cellsCyclin D1Retinoic acidTypes of peptidesMitogenic action