Herbert Yu, MD, PhD

Professor Adjunct

DownloadHi-Res Photo

About

Titles

Professor Adjunct

Professor Adjunct, Chronic Disease Epidemiology

Biography

Dr. Yu is adjunct professor at Yale School of Public Health, Department of Chronic Disease Epidemiology, and a molecular epidemiologist with training in medicine, epidemiology, and clinical biochemistry. Dr. Yu has been involved in cancer research for over 20 years, and has had extensive experience in population-based epidemiologic investigation and patient-based clinical studies. Dr. Yu has conducted numerous epidemiologic and clinical research projects, addressing various issues in cancer research, from etiology to detection, and prognosis to treatment. Dr. Yu is especially experienced in laboratory-based molecular epidemiologic studies, and his research interests include gene-environment interaction in cancer development and progression and lifestyle's impact on epigenetic regulation. Dr. Yu has served on numerous national and international grant review committees, and has been involved in the design, execution and analysis of many epidemiological and clinical studies.

Last Updated on April 07, 2025.

Appointments

Chronic Disease Epidemiology
Professor Adjunct
Primary
Chronic Disease Epidemiology

Education & Training

PhD: University of Toronto (1996)

MSc: University of Toronto (1990)

MD: Shanghai Medical University (1983)

Research

Overview

Role of Genetic and Lifestyle Interplay in Uterus Cancer
Molecular Characterization of the Insulin-like Growth Factor System in Breast Cancer and Ovarian Cancer and its Association with Tumor Progression
Case-control Study of Pancreatic Cancer Etiologic Factors
DNA Methylation in Cancer Risk and Progression
Case-control study of Liver Cancer
GWAS on Endometrial Cancer

Medical Research Interests

Breast Neoplasms; Gene-Environment Interaction; Liver Neoplasms; Molecular Epidemiology; Neoplasms; Ovarian Neoplasms; Uterine Neoplasms

ORCID
0000-0003-3950-4815

Research at a Glance

Yale Co-Authors

Frequent collaborators of Herbert Yu's published research.

Harvey Risch, MD, PhD
View Full Profile
View 15 Common Publications
Lingeng Lu, MD, PhD
View Full Profile
View 13 Common Publications
Wei Zheng
View Full Profile
View 4 Common Publications
Alessandro Santin, MD
View Full Profile
View 3 Common Publications
Melinda Irwin, PhD, MPH
View Full Profile
View 3 Common Publications
Pei Hui, PhD, MD
View Full Profile
View 2 Common Publications

Publications

2026

Understanding Cancer Health Disparities
Zhang J, Du W, Deng Y, Yu H, Fei P. Understanding Cancer Health Disparities. Cancers 2026, 18: 476. PMID: 41681948, PMCID: PMC12896701, DOI: 10.3390/cancers18030476.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Discovery of a Ferroptosis-Related lncRNA–miRNA–mRNA Gene Signature in Endometrial Cancer Through a Comprehensive Co-Expression Network Analysis
Murakami H, Wang J, Yu H. Discovery of a Ferroptosis-Related lncRNA–miRNA–mRNA Gene Signature in Endometrial Cancer Through a Comprehensive Co-Expression Network Analysis. Current Oncology 2026, 33: 37. PMID: 41590357, PMCID: PMC12839614, DOI: 10.3390/curroncol33010037.
Peer-Reviewed Original Research
MeSH Keywords
DCBLD1 Promotes Lung Tumorigenesis by Inhibiting PTP1B Dephosphorylation of EGFR
Liu Y, Li Y, Quan X, Zhang J, Wang Z, Hou Z, Yu H, Liu H, Zhu T, Qian B. DCBLD1 Promotes Lung Tumorigenesis by Inhibiting PTP1B Dephosphorylation of EGFR. International Journal Of Biological Sciences 2026, 22: 684-700. PMID: 41522352, PMCID: PMC12781078, DOI: 10.7150/ijbs.112100.
Peer-Reviewed Original Research
MeSH Keywords

2025

Global, regional, and national burden of hepatocellular carcinoma and contribution of nine modifiable risk factors across 185 countries/territories in 2022
Li P, Ding Z, Feng Y, Ren X, Wei Y, Xia C, Yang Y, Yang Q, Wang Z, Zhang X, van der Geest L, Yu H, Giovannucci E, Smith D, David M, Jemal A, Yu X, Zeng H, Cao G. Global, regional, and national burden of hepatocellular carcinoma and contribution of nine modifiable risk factors across 185 countries/territories in 2022. Science Bulletin 2025, 71: 838-849. PMID: 41565536, DOI: 10.1016/j.scib.2025.12.022.
Peer-Reviewed Original Research
MeSH Keywords
A novel ferroptosis-related microRNAs signature for predicting prognosis in endometrial cancer: An observational study
Murakami H, Wang J, Yu H. A novel ferroptosis-related microRNAs signature for predicting prognosis in endometrial cancer: An observational study. Medicine 2025, 104: e46102. PMID: 41305798, PMCID: PMC12643724, DOI: 10.1097/md.0000000000046102.
Peer-Reviewed Original Research
MeSH Keywords
Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis
Zhang T, Hua X, Mohindroo C, Wang X, Dutta D, Liu J, Katta S, Li S, Wang J, Antwi S, Arslan A, Freeman L, Bracci P, Canzian F, Du M, Gallinger S, Goodman P, Katzke V, Kooperberg C, Le Marchand L, Neale R, Patel A, Perdomo S, Shu X, Visvanathan K, Van Den Eeden S, White E, Zheng W, Albanes D, Andreotti G, Bamlet W, Brennan P, Buring J, Chanock S, Chen Y, Darst B, Ferrari P, Giovannucci E, Goggins M, Haiman C, Hassan M, Holly E, Hung R, Jones M, Kraft P, Kurtz R, Malats N, Moore S, Ng K, Oberg A, Orlow I, Peters U, Porta M, Rabe K, Rothman N, Sánchez M, Sesso H, Silverman D, Southey M, Um C, Yarmolinsky J, Yu H, Yuan C, Zhong J, Wolpin B, Risch H, Amundadottir L, Klein A, Yu K, Zhang H, Stolzenberg-Solomon R. Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis. Journal Of The National Cancer Institute 2025, 118: 437-447. PMID: 41206949, PMCID: PMC13005432, DOI: 10.1093/jnci/djaf308.
Peer-Reviewed Original Research
Construction of a novel ferroptosis-related long non-coding RNAs model for predicting prognosis and tumor immune microenvironment in endometrial cancer
Murakami H, Wang J, Yu H. Construction of a novel ferroptosis-related long non-coding RNAs model for predicting prognosis and tumor immune microenvironment in endometrial cancer. Annals Of Translational Medicine 2025, 13: 53-53. PMID: 41211107, PMCID: PMC12592011, DOI: 10.21037/atm-25-87.
Peer-Reviewed Original Research
Serum Proteomic Profile Based on the TGF‐β Pathway Stratifies Risk of Hepatocellular Carcinoma
Xiang X, Shetty K, Yu H, Mishra B, Wong L, Zhou X, Satapathy S, Crawford J, Latham P, Han S, Mathew B, Dagher N, Lau L, Cacaj F, Vegesna A, Dasarathy S, He A, Huang H, Amdur R, Mishra L. Serum Proteomic Profile Based on the TGF‐β Pathway Stratifies Risk of Hepatocellular Carcinoma. Liver International 2025, 45: e70325. PMID: 40919824, PMCID: PMC12416123, DOI: 10.1111/liv.70325.
Peer-Reviewed Original Research
MeSH Keywords
GWAS meta-analysis identifies five susceptibility loci for endometrial cancer
Ramachandran D, Wang X, Laisk T, Zheng Y, Ingold N, Canson D, Kho P, Naumann B, Chapman C, Bousset K, Krause A, Schürmann P, Wieland B, Hanel P, Hülse F, Häfner N, Runnebaum I, Dubrowinskaja N, Turmanov N, Yugay T, Yessimsiitova Z, Amant F, Annibali D, Beckmann M, Bodelon C, Buchanan D, Chen C, Clarke M, Cook L, De Vivo I, De Wispelaere W, Du M, Easton D, Emons J, Fasching P, Friedenreich C, Gallagher G, Giles G, Goode E, Harris H, Hunter D, Kolin D, Kraft P, Lacey J, Lambrechts D, Lu L, Mutter G, Naduparambil J, O’Connell K, Patel A, Pharoah P, Rebbeck T, Ricceri F, Risch H, Ruebner M, Sacerdote C, Scott R, Setiawan V, Shu X, Southey M, Tham E, Tomlinson I, Turman C, Wentzensen N, Xu W, Yu H, Zheng W, Spurdle A, Yarden Y, Team E, Mägi R, Hillemanns P, Glubb D, Dörk T, O’Mara T. GWAS meta-analysis identifies five susceptibility loci for endometrial cancer. EBioMedicine 2025, 118: 105830. PMID: 40633141, PMCID: PMC12275056, DOI: 10.1016/j.ebiom.2025.105830.
Peer-Reviewed Original Research
MeSH Keywords
Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer
Jung S, Pellegrini M, Tan X, Yu H. Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer. Aging 2025, 17: 1624-1666. PMID: 40632935, PMCID: PMC12339025, DOI: 10.18632/aging.206276.
Peer-Reviewed Original Research
MeSH Keywords

See All Publications

News

Get In Touch

Contacts

herbert.yu@yale.edu

Academic Office Number

808.421.9375

Lab Number

203.785.7062

Office Fax Number

203.785.6980

Mailing Address

Chronic Disease Epidemiology

PO Box 208034, 60 College Street

New Haven, CT 06520-8034

United States

Administrative Support

Lingeng Lu, MD, PhD
Research Scientist in Epidemiology (Chronic Diseases)

Locations

60 College Street
Academic Office
Ste 700
New Haven, CT 06510
Get Directions

Titles

Biography

Appointments

Chronic Disease Epidemiology

Other Departments & Organizations

Education & Training

Overview

Medical Research Interests

ORCID

Research at a Glance

Yale Co-Authors

Harvey Risch, MD, PhD

Lingeng Lu, MD, PhD

Wei Zheng

Alessandro Santin, MD

Melinda Irwin, PhD, MPH

Pei Hui, PhD, MD

Publications

2026

2025

News

Exercise is Associated with Reduced Endometrial Cancer Risk

Multimillion Dollar NIH Grant Funds YSPH Research on Liver Cancer

Yale Researcher Receives Grant to Study Pancreatic Cancer

Yu Co-researcher on Test Detecting Early Stage Ovarian Cancer With 99 Percent Accuracy

Contacts

Administrative Support

Locations

60 College Street