2021
(E)-N-(2-(3, 5-Dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) induces cytoprotection in CCD18-Co human colon fibroblast cells through Nrf2/ARE pathway activation
Tan H, Thomas N, Inayat-Hussain S, Chan K. (E)-N-(2-(3, 5-Dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) induces cytoprotection in CCD18-Co human colon fibroblast cells through Nrf2/ARE pathway activation. Scientific Reports 2021, 11: 4773. PMID: 33637843, PMCID: PMC7910600, DOI: 10.1038/s41598-021-83163-7.Peer-Reviewed Original ResearchConceptsGlutamate-cysteine ligase catalytic subunitGlutathione S-transferaseNrf2/ARE pathway activationDissociation of Nrf2New mechanistic insightsCatalytic subunitNrf2/ARE pathwayN-furanPromoter activityMolecular mechanismsResponse elementCytoprotective proteinsInhibitory proteinS-transferaseQuinone oxidoreductase 1Mitochondrial damageCytoprotective enzymesMechanistic insightsARE pathwayProtein expressionFactor 2Pathway activationNuclear factorNormal cellsFibroblast cells
2020
Cytoprotective effects of (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) against 4-nitroquinoline 1-oxide-induced damage in CCD-18Co human colon fibroblast cells
Tan H, Thomas N, Inayat-Hussain S, Chan K. Cytoprotective effects of (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) against 4-nitroquinoline 1-oxide-induced damage in CCD-18Co human colon fibroblast cells. PLOS ONE 2020, 15: e0223344. PMID: 32365104, PMCID: PMC7197815, DOI: 10.1371/journal.pone.0223344.Peer-Reviewed Original ResearchConceptsNormal human colon fibroblastMitochondrial damageMitochondrial membrane potentialNitrosative stressHuman colon fibroblastsN-furanDNA strand breaksCellular DNACCD-18Co cellsCytoprotective effectsStrand breaksColon fibroblastsProtein expressionDNAMembrane potentialFibroblast cellsMicronucleus formationOxidative stressCytoprotective potentialCell modelGroup of chemicalsCellsNitric oxide levelsPotential chemopreventive activityGlutathione levels
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