2020
Cytoprotective effects of (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) against 4-nitroquinoline 1-oxide-induced damage in CCD-18Co human colon fibroblast cells
Tan H, Thomas N, Inayat-Hussain S, Chan K. Cytoprotective effects of (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) against 4-nitroquinoline 1-oxide-induced damage in CCD-18Co human colon fibroblast cells. PLOS ONE 2020, 15: e0223344. PMID: 32365104, PMCID: PMC7197815, DOI: 10.1371/journal.pone.0223344.Peer-Reviewed Original ResearchConceptsNormal human colon fibroblastMitochondrial damageMitochondrial membrane potentialNitrosative stressHuman colon fibroblastsN-furanDNA strand breaksCellular DNACCD-18Co cellsCytoprotective effectsStrand breaksColon fibroblastsProtein expressionDNAMembrane potentialFibroblast cellsMicronucleus formationOxidative stressCytoprotective potentialCell modelGroup of chemicalsCellsNitric oxide levelsPotential chemopreventive activityGlutathione levels
2012
3,5-Dibenzyloxy-4’-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells
Roslie H, Chan K, Rajab N, Velu S, Kadir S, Bunyamin I, Weber J, Thomas N, Majeed A, Myatt G, Inayat-Hussain S. 3,5-Dibenzyloxy-4’-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells. The Journal Of Toxicological Sciences 2012, 37: 13. PMID: 22293408, DOI: 10.2131/jts.37.13.Peer-Reviewed Original Research
2010
Cytotoxic and antioxidant effects of methoxylated stilbene analogues on HepG2 hepatoma and Chang liver cells: Implications for structure activity relationship
Hasiah A, Ghazali A, Weber J, Velu S, Thomas N, Inayat Hussain S. Cytotoxic and antioxidant effects of methoxylated stilbene analogues on HepG2 hepatoma and Chang liver cells: Implications for structure activity relationship. Human & Experimental Toxicology 2010, 30: 138-144. PMID: 20385705, DOI: 10.1177/0960327110368739.Peer-Reviewed Original ResearchConceptsChang liver cellsHepG2 hepatomaTotal antioxidant activityLiver cellsCytotoxic effectsAntioxidant activityFerric Reducing Antioxidant Power AssayChemopreventive activityAntioxidant effectsAntioxidant power assayStilbene analoguesSelective antiproliferative agentsStructure-activity relationship studiesHepG2 cellsAntiproliferative agentsHighest antioxidant activityPower assayHepatomaActivity relationship studiesStructural activity relationshipCytotoxicCellsActivity relationshipsRelationship studiesStructure-activity relationships
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