HIV, inflammation, and initiation of methamphetamine use in sexual and gender minorities assigned male at birth
Carrico A, Ryan D, Berona J, Dominguez B, Schrock J, McDade T, Newcomb M, D’Aquila R, Mustanski B. HIV, inflammation, and initiation of methamphetamine use in sexual and gender minorities assigned male at birth. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2407046121. PMID: 39348540, PMCID: PMC11474050, DOI: 10.1073/pnas.2407046121.Peer-Reviewed Original ResearchConceptsMethamphetamine useHIV diagnosisRate of incidenceRisk factorsHigh C-reactive proteinCox proportional-hazards modelC-reactive proteinPrevalence of methamphetamine useProportional-hazards modelSGM peopleIdentified risk factorsGender minoritiesInitiation of methamphetamine useHIV seroconversionInflammatory measuresPoisson regression analysisCohort studyHIVMethamphetaminePreventive interventionsBirthInflammationRegression analysisIncidenceDiagnosisHuman induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient
Tatekoshi Y, Chen C, Shapiro J, Chang H, Blancard M, Lyra-Leite D, Burridge P, Feinstein M, D'Aquila R, Hsue P, Ardehali H. Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient. ELife 2024, 13: rp95867. PMID: 39331464, PMCID: PMC11434618, DOI: 10.7554/elife.95867.Peer-Reviewed Original ResearchConceptsHuman induced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesUptake in vitroHIV viremiaDiastolic dysfunctionHIV patientsCardiomyocyte relaxationSarcoplasmic reticulumSGLT2 inhibitorsHeart failurePotential new interventionsInflammatory cytokinesAnimal modelsHFpEFStudy molecular mechanismsMito-TEMPOCardiomyocytesCytokinesHIVPatientsRelaxation defectsPLWHSerumHuman induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient
Tatekoshi Y, Chen C, Shapiro J, Chang H, Blancard M, Lyra-Leite D, Burridge P, Feinstein M, D'Aquila R, Hsue P, Ardehali H. Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient. ELife 2024, 13 DOI: 10.7554/elife.95867.3.Peer-Reviewed Original ResearchHuman induced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesUptake in vitroCa 2HIV viremiaDiastolic dysfunctionCardiomyocyte relaxationHIV patientsSarcoplasmic reticulumSGLT2 inhibitorsHeart failurePotential new interventionsInflammatory cytokinesAnimal modelsHFpEFStudy molecular mechanismsMito-TEMPOCardiomyocytesHIVCytokinesRelaxation defectsPatientsPLWHAsymptomatic Rectal Bacterial Pathogens Show Large Prospective Relationships With HIV Incidence in a Cohort of Young Sexual and Gender Minorities: Implications for STI Screening and HIV Prevention
Baiers R, Ryan D, Clifford A, Munson E, D’Aquila R, Newcomb M, Mustanski B. Asymptomatic Rectal Bacterial Pathogens Show Large Prospective Relationships With HIV Incidence in a Cohort of Young Sexual and Gender Minorities: Implications for STI Screening and HIV Prevention. Open Forum Infectious Diseases 2024, 11: ofae444. PMID: 39183815, PMCID: PMC11342390, DOI: 10.1093/ofid/ofae444.Peer-Reviewed Original ResearchHIV seroconversionGeneralized estimating equationsChlamydia trachomatisNeisseria gonorrhoeaeHIV infectionPredictors of HIV seroconversionLongitudinal cohort studyPrevent HIV infectionGender minoritiesSTI screeningRectal NGHIV preventionBiobehavioral interventionsHIV incidenceMultivariate GEE analysisAsymptomatic screeningMethods DataStatistically significant predictorsProspective relationshipHIVChicago metropolitan areaPredictive valueEstimating equationsGEE analysisStatistically significant pairwise differences
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