2025
Association between city-level sociodemographic and health factors and the prevalence of antimicrobial-resistant gonorrhea in the US, 2000–2019: a spatial–temporal modeling study
Li J, Murray-Watson R, St Cyr S, Grad Y, Warren J, Yaesoubi R. Association between city-level sociodemographic and health factors and the prevalence of antimicrobial-resistant gonorrhea in the US, 2000–2019: a spatial–temporal modeling study. The Lancet Regional Health - Americas 2025, 43: 101006. PMID: 39968293, PMCID: PMC11834109, DOI: 10.1016/j.lana.2025.101006.Peer-Reviewed Original ResearchGonococcal Isolate Surveillance ProjectAssociated with higher prevalenceAntimicrobial-resistantPenicillin resistancePrevalence of ciprofloxacin resistancePrevalence of tetracycline resistanceTetracycline resistanceHealth factorsDrug susceptibility testingResistant to ciprofloxacinSexually-transmitted diseases clinicSurveillance systemPrevalence of HIVHighest incidence of gonorrhoeaIncidence of gonorrheaSentinel surveillance systemProportion of isolatesAMR surveillance systemUS National Institutes of HealthCiprofloxacin resistanceSymptomatic menUrethral gonorrhoeaSusceptibility testingPopulation-level riskDisease clinic
2024
Assessing thresholds of resistance prevalence at which empiric treatment of gonorrhea should change among men who have sex with men in the US: A cost-effectiveness analysis
Yin X, Li Y, Rönn M, Li S, Yuan Y, Gift T, Hsu K, Salomon J, Grad Y, Yaesoubi R. Assessing thresholds of resistance prevalence at which empiric treatment of gonorrhea should change among men who have sex with men in the US: A cost-effectiveness analysis. PLOS Medicine 2024, 21: e1004424. PMID: 38976754, PMCID: PMC11262662, DOI: 10.1371/journal.pmed.1004424.Peer-Reviewed Original ResearchDrug susceptibility testingQuality-adjusted life yearsFirst-line therapyFirst-line antibioticsNet health benefitFirst-lineRetreatment regimensResistance prevalenceRapid drug susceptibility testingRate of treatment failureTreatment of gonorrheaIncidence of gonorrheaAssociated with gonorrheaEmpirical therapyTreatment failureEmpirical treatmentGonococcal infectionSusceptibility testingGonorrhea casesMSM populationGonorrheaCost-effectiveness analysisDiagnostic testsResistant strainsTherapy
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