Peter Guarino, MPH, PhD
Assistant Professor Adjunct of BiostatisticsAbout
Titles
Assistant Professor Adjunct of Biostatistics
Director, Statistical Center for HIV / AIDS Research and Prevention, Fred Hutchinson Cancer Research Center
Biography
Peter Guarino is currently the Director of the Statistical Center for HIV / AIDS Research and Prevention (SCHARP) at the Fred Hutchinson Cancer Research Center in Seattle, WA. SCHARP is the Statistical and Data Management Center (SDMC) for multiple HIV research networks, including HIV Prevention Trials Network , HIV Vaccine Trials Network, Microbicides Trial Network, Collaboration for AIDS Vaccine Discovery, and Vaccine Immunology Statistical Center. Prior to directing SCHARP, Peter was the Director of the VA Cooperative Studies Program Coordinating Center at the VA Connecticut Healthcare System in West Haven, CT. He is also currently an assistant clinical professor of biostatistics at YSPH. Dr. Guarino has more than 15 years’ experience in the design, conduct and analysis of clinical trials. His primary research interests are in measuring and improving the effectiveness of informed consent in clinical research, improving the quality and efficiency of the design, conduct and analysis of multicenter clinical trials and comparative effectiveness studies.
Appointments
Biostatistics
Assistant Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of London (2005)
- MPH
- Yale University (1998)
Research
Publications
2024
Efficacy and safety of implantable cardioverter-defibrillator implantation in the elderly—The I-70 Study: A randomized clinical trial
Singh S, Wininger M, Raitt M, Adabag S, Moore H, Rottman J, Scrymgeour A, Zhang J, Zheng K, Guarino P, Kyriakides T, Group I, Johnson G, Williams A, Beed A, MacMurdy K, Saavedra P. Efficacy and safety of implantable cardioverter-defibrillator implantation in the elderly—The I-70 Study: A randomized clinical trial. Heart Rhythm O2 2024, 5: 365-373. PMID: 38984364, PMCID: PMC11228113, DOI: 10.1016/j.hroo.2024.04.010.Peer-Reviewed Original ResearchImplantable cardioverter defibrillatorParticipant follow-upPatient treatment preferencesICD implantationFollow-upTarget sample sizeAll-cause hospitalizationsPrimary prevention ICD implantationMonths of follow-upImplantable cardioverter defibrillator therapySafety of implantable cardioverter defibrillatorsImplantable cardioverter defibrillator implantationOptimal medical therapyRate of sudden deathTreatment preferencesImplantable cardioverter defibrillator shocksSafety of ICD implantationConfidence intervalsStudy protocolMedical therapyParticipantsProlonging lifePatientsSudden deathCardioverter defibrillator
2014
Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial
Dysken MW, Sano M, Asthana S, Vertrees JE, Pallaki M, Llorente M, Love S, Schellenberg GD, McCarten JR, Malphurs J, Prieto S, Chen P, Loreck DJ, Trapp G, Bakshi RS, Mintzer JE, Heidebrink JL, Vidal-Cardona A, Arroyo LM, Cruz AR, Zachariah S, Kowall NW, Chopra MP, Craft S, Thielke S, Turvey CL, Woodman C, Monnell KA, Gordon K, Tomaska J, Segal Y, Peduzzi PN, Guarino PD. Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial. JAMA 2014, 311: 33-44. PMID: 24381967, PMCID: PMC4109898, DOI: 10.1001/jama.2013.282834.Peer-Reviewed Original ResearchConceptsAlpha-tocopherol groupModerate Alzheimer's diseaseIU/dAlzheimer's diseaseFunctional declineTocopherol groupAlpha-tocopherolVitamin EAlzheimer's Disease Cooperative Study/ActivitiesVeterans Affairs Medical CenterInventory scoresSlow functional declineSerious adverse eventsSevere Alzheimer's diseaseMemantine groupCause mortalityPlacebo groupSecondary outcomesAdverse eventsRandomized trialsClinical progressionCombination groupCaregiver burdenClinical trialsSlow progression
2013
Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy
Fried LF, Emanuele N, Zhang JH, Brophy M, Conner TA, Duckworth W, Leehey DJ, McCullough PA, O'Connor T, Palevsky PM, Reilly RF, Seliger SL, Warren SR, Watnick S, Peduzzi P, Guarino P. Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy. New England Journal Of Medicine 2013, 369: 1892-1903. PMID: 24206457, DOI: 10.1056/nejmoa1303154.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseGlomerular filtration rateAngiotensin receptor blockersAcute kidney injuryCombination therapyEnd pointKidney injuryDiabetic nephropathyPrimary end-point eventAngiotensin-converting enzyme inhibitorPrimary end pointSecondary end pointsCombination therapy groupRenal end pointsRisk of hyperkalemiaEnd-point eventsType 2 diabetesBody surface areaConclusion Combination therapyAngiotensin inhibitionCardiovascular eventsMonotherapy groupAdverse eventsCreatinine ratioRenal disease
2010
Robot-Assisted Therapy for Long-Term Upper-Limb Impairment after Stroke
Lo AC, Guarino PD, Richards LG, Haselkorn JK, Wittenberg GF, Federman DG, Ringer RJ, Wagner TH, Krebs HI, Volpe BT, Bever CT, Bravata DM, Duncan PW, Corn BH, Maffucci AD, Nadeau SE, Conroy SS, Powell JM, Huang GD, Peduzzi P. Robot-Assisted Therapy for Long-Term Upper-Limb Impairment after Stroke. New England Journal Of Medicine 2010, 362: 1772-1783. PMID: 20400552, PMCID: PMC5592692, DOI: 10.1056/nejmoa0911341.Peer-Reviewed Original ResearchConceptsWolf Motor Function TestFugl-Meyer scoreUsual careMotor Function TestRobot-assisted therapyStroke Impact ScaleIntensive therapySecondary analysisFunction testsComparison therapyMotor functionImpact ScaleSerious adverse eventsFugl-Meyer AssessmentUpper limb deficitsLong-term deficitsSensorimotor recoveryAdverse eventsSecondary outcomesPrimary outcomeRehabilitative therapyPatientsLimb impairmentTherapyStroke
2009
National Institutes of Health State-of-the-Science Conference Statement: Family History and Improving Health
Berg A, Baird M, Botkin J, Driscoll D, Fishman P, Guarino P, Hiatt R, Jarvik G, Millon-Underwood S, Morgan T, Mulvihill J, Pollin T, Schimmel S, Stefanek M, Vollmer W, Williams J. National Institutes of Health State-of-the-Science Conference Statement: Family History and Improving Health. Annals Of Internal Medicine 2009, 151: 872-877. DOI: 10.7326/0000605-200912150-00165.Peer-Reviewed Original ResearchNational Institutes of Health State-of-the-Science Conference Statement: Family History and Improving Health.
Berg A, Baird M, Botkin J, Driscoll D, Fishman P, Guarino P, Hiatt R, Jarvik G, Millon-Underwood S, Morgan T, Mulvihill J, Pollin T, Schimmel S, Stefanek M, Vollmer W, Williams J. National Institutes of Health State-of-the-Science Conference Statement: Family History and Improving Health. Annals Of Internal Medicine 2009, 151: 872-7. PMID: 19884615, DOI: 10.7326/0003-4819-151-12-200912150-00165.Peer-Reviewed Original ResearchConceptsNational Institutes of Health consensusAssessment of medical knowledgeNational InstituteNational Institutes of HealthHealth professionalsInstitutes of HealthImprove healthClosed deliberationsPublic representativesFamily historyIndependent panels of health professionalsPublic sessionSystematic literature reviewMedical knowledgeConference attendeesPanel's assessment of medical knowledgePanel assessmentHealthPolicy statementsSessionsLiterature reviewIndependent panelNationalMedical researchAHRQNational Institutes of Health State-of-the-Science Conference Statement: Family History and Improving Health: August 24-26, 2009.
Berg A, Baird M, Botkin J, Driscoll D, Fishman P, Guarino P, Hiatt R, Jarvik G, Millon-Underwood S, Morgan T, Mulvihill J, Pollin T, Schimmel S, Stefanek M, Vollmer W, Williams J. National Institutes of Health State-of-the-Science Conference Statement: Family History and Improving Health: August 24-26, 2009. NIH Consensus And State-of-the-Science Statements 2009, 26: 1-19. PMID: 19721470.Peer-Reviewed Original Research
2006
A brief measure of perceived understanding of informed consent in a clinical trial was validated
Guarino P, Lamping DL, Elbourne D, Carpenter J, Peduzzi P. A brief measure of perceived understanding of informed consent in a clinical trial was validated. Journal Of Clinical Epidemiology 2006, 59: 608-614. PMID: 16713523, DOI: 10.1016/j.jclinepi.2005.11.009.Peer-Reviewed Original ResearchConceptsInformed Consent QuestionnaireClinical trialsGulf War veterans' illnessesPsychometric evaluationRandomized clinical trialsItem reduction techniquesVeterans AffairsItem reductionTrialsMonthsPoor acceptabilityFour-item subscaleValidity sampleIllnessGood acceptabilityInternal consistencyConsentBaselineSelf-report measuresBrief measureAcceptabilityParticipantsHospitalFollowConsumer involvement in consent document development: a multicenter cluster randomized trial to assess study participants' understanding
Guarino P, Elbourne D, Carpenter J, Peduzzi P. Consumer involvement in consent document development: a multicenter cluster randomized trial to assess study participants' understanding. Clinical Trials 2006, 3: 19-30. PMID: 16539087, DOI: 10.1191/1740774506cn133oa.Peer-Reviewed Original ResearchConceptsGulf War veterans' illnessesStudy participantsClient Satisfaction Questionnaire-8Outcome assessment questionnaireProportion of patientsPrimary outcome measureMean treatment differenceUS medical centersConsent documentsSignificant differencesPotential study participantsSecondary outcomesAdherence ratesTrial protocolClinical trialsMulticenter clusterOutcome measuresMedical CenterStudy investigatorsAssessment QuestionnaireStudy refusalThree monthsTrial initiationClinical researchInformed consent