Peter Diggle, PhD
Professor Adjunct of BiostatisticsCards
About
Research
Overview
Medical Research Interests
Statistics as Topic
Public Health Interests
Modeling
Publications
2025
A systematic review of variables associated with snakebite risk in spatial and temporal analyses
Collinson S, Lamb T, Cardoso I, Diggle P, Lalloo D. A systematic review of variables associated with snakebite risk in spatial and temporal analyses. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2025, trae131. PMID: 39817354, DOI: 10.1093/trstmh/trae131.Peer-Reviewed Original ResearchSystematic reviewJoanna Briggs Institute toolHealth facility reportingRisk estimation accuracyWeb of ScienceNarrative synthesisFacility reportsStudy qualityAd hoc surveyResearch availabilityHigh-risk regionsIncidence dataSub-Saharan AfricaUrban residentsGlobal healthPositive associationSnakebite riskInstitutional toolsRisk variationStatistical associationNegative associationSub-SaharanCase incidenceAssociationRiskCommunity-based snakebite risk mapping for resource prioritisation in Eastern Province, Rwanda
Ediriweera D, Hakizimana D, Diggle P, Schurer J. Community-based snakebite risk mapping for resource prioritisation in Eastern Province, Rwanda. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2025, 119: 310-316. PMID: 39749566, DOI: 10.1093/trstmh/trae069.Peer-Reviewed Original ResearchConceptsSnakebite incidenceHealth worker trainingResource prioritisationEvidence-based decisionsEastern ProvinceResource-poor countriesHousehold visitsSnakebite preventionSnakebite eventsSurveillance of peopleSnakebite riskWorker trainingWell-trained personnelMedical emergencyHigh riskLow riskRisk mapsSnakebite envenomingRiskPrediction mapsSnakebitePrioritisationGeostatistical modelSpatial variationLow incidence
2024
Cost-effectiveness of comparative survey designs for helminth control programs: Post-hoc cost analysis and modelling of the Kenyan national school-based deworming program
Minnery M, Okoyo C, Morgan G, Wang A, Johnson O, Fronterre C, Montresor A, Campbell S, Mwandawiro C, Diggle P. Cost-effectiveness of comparative survey designs for helminth control programs: Post-hoc cost analysis and modelling of the Kenyan national school-based deworming program. PLOS Neglected Tropical Diseases 2024, 18: e0011583. PMID: 39621813, PMCID: PMC11666021, DOI: 10.1371/journal.pntd.0011583.Peer-Reviewed Original ResearchUnderstanding the impact of covariates on the classification of implementation units for soil-transmitted helminths control: a case study from Kenya
Puranik A, Diggle P, Odiere M, Gass K, Kepha S, Okoyo C, Mwandawiro C, Wakesho F, Omondi W, Sultani H, Giorgi E. Understanding the impact of covariates on the classification of implementation units for soil-transmitted helminths control: a case study from Kenya. BMC Medical Research Methodology 2024, 24: 294. PMID: 39614175, PMCID: PMC11606136, DOI: 10.1186/s12874-024-02420-1.Peer-Reviewed Original ResearchConceptsPredictive inferenceRemotely sensed covariatesSimulation studyModel-based geostatisticsGeostatistical modelImpact of covariatesSpatially referenced covariatesSample sizeModern statistical methodsModel-based geostatistical methodsCross-sectional surveyCovariatesReduced sample sizeClassification of areasPrevalence predictionsInferenceDisease riskMethodsThis studyPrevalenceSub-countyPrevalence levelsDisentangling the influence of reservoir abundance and pathogen shedding on zoonotic spillover of the Leptospira agent in urban informal settlements
Soni N, Eyre M, Souza F, Diggle P, Ko A, Begon M, Pickup R, Childs J, Khalil H, Carvalho-Pereira T, Pertile A, Carvalho M, de Oliveira D, Nery N, Giorgi E, Costa F. Disentangling the influence of reservoir abundance and pathogen shedding on zoonotic spillover of the Leptospira agent in urban informal settlements. Frontiers In Public Health 2024, 12: 1447592. PMID: 39360250, PMCID: PMC11445007, DOI: 10.3389/fpubh.2024.1447592.Peer-Reviewed Original ResearchRat abundanceReservoir abundanceAbundance of ratsEnvironmentally transmitted diseasesVegetation land coverInfection riskSexually mature ratsHuman infection riskLive trapsUrban informal settlementsZoonotic spilloverLand coverSpatial variationHydrological factorsValley bottomTrack plateAbundanceHuman riskShedding rateMature ratsEco-epidemiological studiesLeptospira infectionSpillover transmissionSpatial distributionInformal settlementsFactors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil
de Oliveira D, Khalil H, Palma F, Santana R, Nery N, Quintero-Vélez J, Zeppelini C, do Sacramento G, Cruz J, Lustosa R, Ferreira I, Carvalho-Pereira T, Diggle P, Wunder E, Ko A, Lopez Y, Begon M, Reis M, Costa F. Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil. PLOS Neglected Tropical Diseases 2024, 18: e0011292. PMID: 38758957, PMCID: PMC11139309, DOI: 10.1371/journal.pntd.0011292.Peer-Reviewed Original ResearchYears of ageResidents of low-income areasMultinomial logistic regression modelWork-related exposureEpidemiological patternsLow-income areasLogistic regression modelsInformal urban communitiesFactors associated with seropositivityCity of SalvadorPathogenic species of bacteriaUrban settingsUrban communitiesLongitudinal Data Analysis
Diggle P, Taylor-Robinson D. Longitudinal Data Analysis. 2024, 1-34. DOI: 10.1007/978-1-4614-6625-3_75-1.Peer-Reviewed Original ResearchTime-to-event outcomesBinary responsesTreatment of missing valuesClinical trials of drug therapyJoint modelTrials of drug therapyCystic fibrosis patientsLongitudinal studyLinear modelCross-sectional studySchizophrenia patientsFibrosis patientsLong-term progressionDrug therapyClinical trialsLung functionObservational studyNon-independencePatientsOutcome variablesStatistical methodsImproving the Cost-efficiency of Preventive Chemotherapy: Impact of New Diagnostics on Stopping Decisions for Control of Schistosomiasis
Coffeng L, Graham M, Browning R, Kura K, Diggle P, Denwood M, Medley G, Anderson R, de Vlas S. Improving the Cost-efficiency of Preventive Chemotherapy: Impact of New Diagnostics on Stopping Decisions for Control of Schistosomiasis. Clinical Infectious Diseases 2024, 78: s153-s159. PMID: 38662699, PMCID: PMC11045014, DOI: 10.1093/cid/ciae020.Peer-Reviewed Original ResearchHow Does the Proportion of Never Treatment Influence the Success of Mass Drug Administration Programs for the Elimination of Lymphatic Filariasis?
Kura K, Stolk W, Basáñez M, Collyer B, de Vlas S, Diggle P, Gass K, Graham M, Hollingsworth T, King J, Krentel A, Anderson R, Coffeng L. How Does the Proportion of Never Treatment Influence the Success of Mass Drug Administration Programs for the Elimination of Lymphatic Filariasis? Clinical Infectious Diseases 2024, 78: s93-s100. PMID: 38662701, PMCID: PMC11045024, DOI: 10.1093/cid/ciae021.Peer-Reviewed Original ResearchConceptsMass drug administrationElimination of lymphatic filariasisEfficacious treatment regimensLymphatic filariasisLevels of NTMass drug administration programmesYears of annual treatmentTreatment regimensDrug combinationsTransmission settingsMass drug administration programsDrug AdministrationTreatment coveragePrevalenceTransmission areasMDA coverageBaselineProportion of peopleTreatmentPrevalence thresholdImpact of NTAlbendazoleDiethylcarbamazineHighest infection prevalenceHighest proportionA Comparison of Markov and Mechanistic Models for Soil-Transmitted Helminth Prevalence Projections in the Context of Survey Design
Eyre M, Bulstra C, Johnson O, de Vlas S, Diggle P, Fronterrè C, Coffeng L. A Comparison of Markov and Mechanistic Models for Soil-Transmitted Helminth Prevalence Projections in the Context of Survey Design. Clinical Infectious Diseases 2024, 78: s146-s152. PMID: 38662703, PMCID: PMC11045013, DOI: 10.1093/cid/ciae022.Peer-Reviewed Original ResearchConceptsOptimal survey designImpact assessment surveysSurvey designProjected prevalenceGeostatistical methodsPrevalence surveySampling designSchool-aged childrenPreventive chemotherapySoil-transmitted helminthsPrevalence projectionsControl programsWorld Health OrganizationAssessment surveyPrevalence dataSub-Saharan AfricaMechanistic modelTarget of PCSoutheast AsiaHealth OrganizationMechanistic methodsPrevalenceBillion peopleSub-SaharanInadequate sanitation
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