2025
Floods and cause-specific mortality in the United States applying a triply robust approach
Chu L, Warren J, Spatz E, Lowe S, Lu Y, Ma X, Ross J, Krumholz H, Chen K. Floods and cause-specific mortality in the United States applying a triply robust approach. Nature Communications 2025, 16: 2853. PMID: 40122917, PMCID: PMC11930965, DOI: 10.1038/s41467-025-58236-0.Peer-Reviewed Original ResearchConceptsCDC's National Center for Health StatisticsNational Center for Health StatisticsCause-specific mortality ratesCenter for Health StatisticsCause-specific mortalityHealth impacts of floodingExcess all-cause deathsLong-term health risksFlood daysLong-term associationDeath recordsHealth StatisticsConfounder adjustmentExternal causesStorm Events DatabaseAll-cause deathHealth impactsImpact of floodsPropensity scorePost‐flood yearMortality rateMyocardial infarctionPost-floodContiguous U.S.Respiratory diseaseShort-term exposure to ambient nitrogen dioxide and fine particulate matter and cause-specific mortality: A causal modeling approach in four regions
Marb A, Ma Y, Nobile F, Dubrow R, Kinney P, Stafoggia M, Chen K, Peters A, Breitner S. Short-term exposure to ambient nitrogen dioxide and fine particulate matter and cause-specific mortality: A causal modeling approach in four regions. Environmental Pollution 2025, 372: 126059. PMID: 40089139, DOI: 10.1016/j.envpol.2025.126059.Peer-Reviewed Original ResearchParticulate matterAir pollutionDaily NO<sub>2</sub> anShort-term air pollution exposureNitrogen dioxideDaily air pollution dataExposure to NO<sub>2</sub>Effects of air pollutionShort-term exposure to NO<sub>2</sub> anFine particulate matterTwo-pollutant modelsExposure to ambient nitrogen dioxideAmbient air pollutionAmbient particulate matterAir pollution dataAir pollution exposureCause-specific mortality ratesAmbient nitrogen dioxideRural populationCause-specific mortalityRespiratory mortality ratesMortality rateCause-specific deathCardiovascular mortality ratesPollution exposureShort‐Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study
Zhang S, Chu L, Lu Y, Wei J, Dubrow R, Chaudhry S, Spatz E, Krumholz H, Chen K. Short‐Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study. GeoHealth 2025, 9: e2024gh001234. PMID: 39968338, PMCID: PMC11833228, DOI: 10.1029/2024gh001234.Peer-Reviewed Original ResearchAcute myocardial infarction subtypeShort-term associationsAcute myocardial infarctionAcute myocardial infarction onsetAMI riskEffect modificationAssociated with increased AMI riskParticipant's home addressNon-Hispanic blacksNon-ST-segment elevation acute myocardial infarctionNon-Hispanic whitesCase-crossover designType 1 AMIConditional logistic regressionIncreased AMI riskMyocardial infarction onsetType 2 AMIAcute myocardial infarction patientsST-segment elevation acute myocardial infarctionLifestyle factorsSociodemographic statusHome addressUS hospitalsStratified analysisSpatiotemporal deep learning approachEnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises
Ratjen L, Goddard E, Gilcher E, Nguyen B, Kelley M, Feldman H, Akalaonu K, Nyhan K, Backhaus A, Lascurain M, Wyrtzen N, Smith S, Prabhu M, Lowe S, Chen K, Zimmerman J, Anastas P. EnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises. GeoHealth 2025, 9: e2024gh001254. PMID: 39958831, PMCID: PMC11826329, DOI: 10.1029/2024gh001254.Peer-Reviewed Original ResearchCognitive healthReview of reviewsMental health conditionsMental health crisisAttention-deficit/hyperactivity disorderBehavioral healthMental healthHealth conditionsHealthPublic healthEconomic burdenWell-beingNeuropsychological healthHealth crisisSocial factorsContextual needsAttention-deficit/hyperactivityEnvironmental factorsGreen spacesHealthcareDementiaFunding strategiesConceptual frameworkFundingBurdenLong-term drought and risk of infant mortality in Africa: A cross-sectional study
Wang P, Rogne T, Warren J, Asare E, Akum R, Toure N, Ross J, Chen K. Long-term drought and risk of infant mortality in Africa: A cross-sectional study. PLOS Medicine 2025, 22: e1004516. PMID: 39888958, PMCID: PMC11785314, DOI: 10.1371/journal.pmed.1004516.Peer-Reviewed Original ResearchConceptsRisk of infant mortalityInfant mortality riskCross-sectional studyInfant mortalityMortality riskIncreased risk of infant mortalityIncreased risk of neonatal mortalityIncreased riskRisk of neonatal mortalityHealth Surveys ProgramPost-neonatal mortalityCox regression modelsStatistically significant associationChild healthGlobal burdenNon-casesNeonatal mortalitySignificant associationImpact mortalityNon-exposureSurvival periodRegression modelsPregnancyMortalityHealthThe Pathogenetic Link Between Ozone Pollution and Cardiovascular Disease
Schneider A, Chen K, Breitner S. The Pathogenetic Link Between Ozone Pollution and Cardiovascular Disease. Journal Of The American College Of Cardiology 2025, 85: 622-624. PMID: 39846937, DOI: 10.1016/j.jacc.2024.12.011.Peer-Reviewed Original Research
2024
Ambient Temperature and Stroke Risk Among Adults Aged 18-64 Years A Case-Crossover Study
Chu L, Wang R, Gross C, Chen K, Ma X. Ambient Temperature and Stroke Risk Among Adults Aged 18-64 Years A Case-Crossover Study. Journal Of The American College Of Cardiology 2024, 84: 2327-2331. PMID: 39453364, DOI: 10.1016/j.jacc.2024.08.058.Peer-Reviewed Original ResearchLong-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States
Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz H, Bell M, Chen K. Long-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2403960121. PMID: 39316057, PMCID: PMC11459178, DOI: 10.1073/pnas.2403960121.Peer-Reviewed Original ResearchConceptsWildland firesContiguous United StatesNonaccidental mortalityExposure to ambient fine particlesSmoke PM<sWildland fire smokeMoving average concentrationsAmbient fine particlesLong-term exposureAverage concentrationSmoke PMHealth risksFine particlesFire smokeTemporal confoundingHealth effectsKidney disease mortalityChronic kidney disease mortalityPublic health actionFireMortality rateUnited StatesDisease mortalityHealth actionsMortality outcomesLandscape Fire Air Pollution as a Mediator in Drought and Childhood Stunting Pathway in Low- and Middle-Income Countries
Li J, Wang P, Sutton C, Harker R, Xue T, Chen K. Landscape Fire Air Pollution as a Mediator in Drought and Childhood Stunting Pathway in Low- and Middle-Income Countries. Environmental Science And Technology 2024, 58: 16728-16737. PMID: 39259849, DOI: 10.1021/acs.est.4c04307.Peer-Reviewed Original ResearchConceptsAir pollutionEnhance climate resilienceIncreased air pollutionIncreasing drought conditionsMiddle-income countriesHealth risksWildfireClimate resilienceChildhood stuntingRisk of childhood stuntingPollutionStandardized Precipitation Evapotranspiration IndexMixed-effects regressionDrought conditionsDroughtChild healthStunting riskPersonalized interventionsMiddle-incomeLandscapeIncreased riskMediation analysisStuntingLMICsFireShort-term association between ambient ozone and onset of acute myocardial infarction of young patients: Results from the VIRGO study
Zhang S, Chu L, Lu Y, Krumholz H, Chen K. Short-term association between ambient ozone and onset of acute myocardial infarction of young patients: Results from the VIRGO study. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0539.Peer-Reviewed Original ResearchFloods and cause-specific mortality in the United States during 2001-2020
Chu L, Warren J, Spatz E, Lowe S, Lu Y, Ma X, Ross J, Krumholz H, Chen K. Floods and cause-specific mortality in the United States during 2001-2020. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1705.Peer-Reviewed Original ResearchHigh ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancySimulating desegregation through affordable housing development: An environmental health impact assessment of Connecticut zoning law
Prasanth S, Oloyede N, Zhang X, Chen K, Carrión D. Simulating desegregation through affordable housing development: An environmental health impact assessment of Connecticut zoning law. Health & Place 2024, 88: 103277. PMID: 38781859, PMCID: PMC11190844, DOI: 10.1016/j.healthplace.2024.103277.Peer-Reviewed Original ResearchNon-Hispanic white residentsEnvironmental health equityAmbient environmental exposuresHealth impact assessmentExposure-response functionsEnvironmental health impact assessmentHealth equityHealth inequalitiesNon-HispanicRate of deathExcess deathsWhite residentsEstimated deathsMortality impactLow-income residentsDesegregation policiesEnvironmental exposuresResidential segregationHousing targetsResidentsHousing developmentDeathSimulated movementHealthImpact assessmentAir pollution changes due to COVID-19 lockdowns and attributable mortality changes in four countries
Ma Y, Nobile F, Marb A, Dubrow R, Kinney P, Peters A, Stafoggia M, Breitner S, Chen K. Air pollution changes due to COVID-19 lockdowns and attributable mortality changes in four countries. Environment International 2024, 187: 108668. PMID: 38640613, DOI: 10.1016/j.envint.2024.108668.Peer-Reviewed Original ResearchConceptsMeteorological normalization techniqueAir pollution changesFine particulate matterImprove air qualityEmission control strategiesCentral-southern ItalyPollution changesParticulate matterRegion-specific estimatesAir qualityMeteorological impactsAir pollutionPollutionCOVID-19 lockdownModeling approachAirCaliforniaMortality changesConcentrationJiangsuEmissionTime trendsLocal characteristicsChinaMatterAssociation of exposure to extreme rainfall events with cause-specific mortality in North Carolina, US
Chan K, Ban J, Ma Y, Chen K. Association of exposure to extreme rainfall events with cause-specific mortality in North Carolina, US. Environmental Research Letters 2024, 19: 044006. DOI: 10.1088/1748-9326/ad2dd2.Peer-Reviewed Original ResearchCause-specific mortalityExtreme rainfall eventsDaily total precipitationRainfall eventsCounty-level mortality dataNorth Carolina countiesTime-series studyRisk of mortalityDaily rainfall measurementsNon-accidental diseasesNorth CarolinaMortality dataRespiratory mortalityExternal mortalityMortality riskRainfall measurementsTotal precipitationNon-accidentalRace groupsMeta-analysisCardiovascular diseaseRainfallStudy periodTwo-stage analysisNorthShort-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries
Ma Y, Nobile F, Marb A, Dubrow R, Stafoggia M, Breitner S, Kinney P, Chen K. Short-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries. JAMA Network Open 2024, 7: e2354607. PMID: 38427355, PMCID: PMC10907920, DOI: 10.1001/jamanetworkopen.2023.54607.Peer-Reviewed Original ResearchConceptsShort-term exposure to air pollutionExposure to air pollutionFine particulate matterCross-sectional studyAir pollutionFixed-effects modelParticulate matterShort-term exposure to PM2.5Short-term exposure to fine particulate matterNO2 concentrationsExposure to fine particulate matterMortality rateNitrogen dioxideSignificant effect modificationDaily PM2.5 concentrationsTime-varying confoundersExposure to PM2.5Health outcomesEstimate associationsMortality dataEffect modificationPM2.5 concentrationsMain OutcomesDay-to-dayCentral-southern ItalyImpact of population aging on future temperature-related mortality at different global warming levels
Chen K, de Schrijver E, Sivaraj S, Sera F, Scovronick N, Jiang L, Roye D, Lavigne E, Kyselý J, Urban A, Schneider A, Huber V, Madureira J, Mistry M, Cvijanovic I, Gasparrini A, Vicedo-Cabrera A. Impact of population aging on future temperature-related mortality at different global warming levels. Nature Communications 2024, 15: 1796. PMID: 38413648, PMCID: PMC10899213, DOI: 10.1038/s41467-024-45901-z.Peer-Reviewed Original ResearchPublished research on the human health implications of climate change between 2012 and 2021: cross sectional study
Bartlett V, Doernberg H, Mooghali M, Gupta R, Wallach J, Nyhan K, Chen K, Ross J. Published research on the human health implications of climate change between 2012 and 2021: cross sectional study. BMJ Medicine 2024, 3: e000627. PMID: 38352020, PMCID: PMC10862342, DOI: 10.1136/bmjmed-2023-000627.Peer-Reviewed Original ResearchHealth effects of climate changeHealth research fundingRandom sampleHealth effectsCross sectional studyPeer-reviewed researchWeb of ScienceGrey literatureHealth conditionsSectional studyInclusion criteriaRisk populationHealthHealth impactsHealth implicationsGoogle ScholarResearch articlesNational InstituteFunding sourcesPublication characteristicsResearch fundingPublished researchRiskDisproportionate focusPopulationA unified framework for assessing interaction effects among environmental exposures in epidemiologic studies: A case study on temperature, air pollution, and kidney-related conditions in New York state
Chu L, Chen K, Yang Z, Crowley S, Dubrow R. A unified framework for assessing interaction effects among environmental exposures in epidemiologic studies: A case study on temperature, air pollution, and kidney-related conditions in New York state. Environmental Research 2024, 248: 118324. PMID: 38301759, DOI: 10.1016/j.envres.2024.118324.Peer-Reviewed Original ResearchAir pollutionMultiplicative interaction effectsNew York StateEstimated health burdenCase-crossover designEvaluation of effect modificationBi-variate associationsAssess interaction effectsConditional logistic modelMeasures of exposureInteraction effectsEffect modificationPollutionExposure variablesHealth burdenEpidemiological studiesEnvironmental exposuresLog-linear modelLogistic modelInteraction termsQuantitative frameworkAirCase studyExposureAlert systemOzone-related acute excess mortality projected to increase in the absence of climate and air quality controls consistent with the Paris Agreement
Domingo N, Fiore A, Lamarque J, Kinney P, Jiang L, Gasparrini A, Breitner S, Lavigne E, Madureira J, Masselot P, das Neves Pereira da Silva S, Sheng Ng C, Kyselý J, Guo Y, Tong S, Kan H, Urban A, Orru H, Maasikmets M, Pascal M, Katsouyanni K, Samoli E, Scortichini M, Stafoggia M, Hashizume M, Alahmad B, Diaz M, la Cruz Valencia C, Scovronick N, Garland R, Kim H, Lee W, Tobias A, Íñiguez C, Forsberg B, Åström C, Ragettli M, Guo Y, Pan S, Colistro V, Bell M, Zanobetti A, Schwartz J, Schneider A, Vicedo-Cabrera A, Chen K. Ozone-related acute excess mortality projected to increase in the absence of climate and air quality controls consistent with the Paris Agreement. One Earth 2024, 7: 325-335. PMID: 38420618, PMCID: PMC7615682, DOI: 10.1016/j.oneear.2024.01.001.Peer-Reviewed Original ResearchClimate scenariosOzone-related deathsAir quality regulationsGround-level ozoneAcute mortalityAir quality controlCMIP6 multi-model ensembleParis Climate AgreementMulti-model ensembleQuality regulationsHealth policyEmission changesAssociated with increased mortalityExcess mortalityCMIP6 simulationsClimateParis AgreementEpidemiological dataClimate AgreementDiverse geographical areasCMIP6MortalityGeographical areas
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