2025
Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene
Johnson J, Siblini H, Al‐Hendy A, Segars J, González F, Taylor H, Singh B, Carson S, Christman G, Huang H, Dangi B, Zhang H. Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene. Clinical And Translational Science 2025, 18: e70189. PMID: 40077973, PMCID: PMC11903501, DOI: 10.1111/cts.70189.Peer-Reviewed Original ResearchConceptsEpigallocatechin-3-gallateFolate levelsUterine fibroidsClinical trialsGreen tea extractAssociated with folate deficiencyPresence of MTHFRWomen of childbearing ageSerum folate levelsReduced folate levelsActive clinical trialsReproductive-age womenEffect of epigallocatechin gallateDhfr genotypeDHFR polymorphismTea extractDaily doseClomiphene citrateUnexplained infertilityFolate deficiencyChildbearing ageClinical studiesTreated womenFibroidsLetrozoleIdentifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation
Dai W, Zhang H. Identifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation. Journal Of The American Statistical Association 2025, ahead-of-print: 1-19. DOI: 10.1080/01621459.2025.2450837.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsDetect single nucleotide polymorphismsGene-based analysisControlling false discovery rateControlling false discoveriesSNP setsFunctional connectivityFalse discovery rateGenetic architectureNovel genesGenetic basisNucleotide polymorphismsGenetic variantsUK Biobank dataPsychiatric disordersDiscovery rateBrain functionFalse discoveriesBiobank dataCorrelations of neural activityBrain regionsBiological etiologyBrain connectivityEQTLNeural activitySex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data
Hu Y, Che M, Zhang H. Sex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data. Genetic Epidemiology 2025, 49: e70004. PMID: 40007508, PMCID: PMC11924109, DOI: 10.1002/gepi.70004.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle-nucleotide polymorphismsAssociation studiesAlpha geneEstrogen receptor alpha geneGenetic risk factorsRisk lociGenomic associationsMajor depressive disorderMDD phenotypesGenetic studiesGenetic associationRisk factors of MDDGenesESR1 geneUK BiobankESR1Participant genotypesPolymorphismSex-specificSex-specific associationsDepressive disorderRacial/ethnic disparitiesFindings lack consistencyLength of lifeEmpowering genome-wide association studies via a visualizable test based on the regional association score
Jiang Y, Zhang H. Empowering genome-wide association studies via a visualizable test based on the regional association score. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2419721122. PMID: 39999171, PMCID: PMC11892588, DOI: 10.1073/pnas.2419721122.Peer-Reviewed Original Research
2024
A re-look at the relevance of TSH and thyroid autoimmunity for pregnancy outcomes: Analyses of RCT data from PPCOS II and AMIGOS
Kuokkanen S, Seungdamrong A, Santoro N, Lieman H, Sun F, Wild R, Zhang H, Pal L. A re-look at the relevance of TSH and thyroid autoimmunity for pregnancy outcomes: Analyses of RCT data from PPCOS II and AMIGOS. Fertility And Sterility 2024 PMID: 39672366, DOI: 10.1016/j.fertnstert.2024.12.005.Peer-Reviewed Original ResearchThyroid-stimulating hormoneRandomized controlled trialsTPO-AbThyroid autoimmunityPregnancy outcomesAssessment of Multiple Intrauterine GestationsRetrospective cohort analysis of dataRisk of pregnancy lossEarly preterm birthMaternal TSH levelsThyroid peroxidase antibodyCohort analysis of dataRetrospective cohort analysisBody mass indexDuration of infertilityAnalysis of RCT dataPolycystic ovary syndromeIntrauterine gestationPreterm birthTSH levelsPeroxidase antibodiesOvarian stimulationLive birthsPPCOS IIStimulating hormoneEffect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controlled Trial
Ma X, Wang J, Shi Y, Tan J, Guan Y, Sun Y, Zhang B, Zhao J, Liu J, Cao Y, Li H, Zhang C, Chen F, Yi H, Wang Z, Xin X, Kong P, Lu Y, Huang L, Yuan Y, Liu H, Li C, Mol B, Hu Z, Zhang H, Chen Z, Liu J. Effect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controlled Trial. Nature Communications 2024, 15: 7747. PMID: 39237545, PMCID: PMC11377718, DOI: 10.1038/s41467-024-52008-y.Peer-Reviewed Original ResearchConceptsLive birth rateIn vitro fertilizationCumulative live birth rateCumulative live birthBlastocyst transferBlastocyst-stageCleavage-stageEmbryo transferLive birthsHigher preterm birth rateBlastocyst-stage groupBlastocyst-stage transferCleavage-stage groupCleavage-stage transferPreterm birth rateYear of randomizationMulticenter randomized controlled trialPrognosis womenRandomized controlled trialsPregnancy outcomesCounseling patientsRandomized trialsNon-inferiorityPrimary outcomeSecondary outcomesAN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY.
Dai W, Zhang H. AN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY. The Annals Of Applied Statistics 2024, 18: 2277-2294. PMID: 39640845, PMCID: PMC11616023, DOI: 10.1214/24-aoas1880.Peer-Reviewed Original ResearchGenetic variantsFunctional connectivityEffects of multiple genetic variantsMediation modelBehavioral outcomesEffects of genetic variantsMultiple genetic variantsCumulative genetic effectsFluid intelligenceUnivariate mediatorImpact of geneticsCognitive behaviorVisual networkGenetic effectsNeural circuitsNetwork mediatorsFunctional networksYoung adultsVariantsVariant Selection and Aggregation of Genetic Association Studies in Precision Medicine
Hu J, Wang S, Zhang H. Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine. ICSA Book Series In Statistics 2024, 423-451. DOI: 10.1007/978-3-031-50690-1_17.Peer-Reviewed Original ResearchAssociation studiesGenetic association studiesPrecision medicineTests of associationHeterogeneous drug responsesDisease risk predictionVariant identificationSignal variantsControl of type I errorDisease riskDrug responseGenomic profilingType I errorRisk predictionGenetic biomarkersVariantsPharmaceutical interventionsMarginal testsAssociation methodAssociationMedicineInterventionIdentificationReplicationDiseaseThe effect of improved metabolic syndrome parameters on live birth
Spitzer T, Diamond M, Wild R, Legro R, Zhang H, Sun F, Ling S, Santoro N. The effect of improved metabolic syndrome parameters on live birth. Fertility And Sterility 2024, 122: 373-375. PMID: 38641159, DOI: 10.1016/j.fertnstert.2024.04.020.Peer-Reviewed Original ResearchMetabolic syndrome Z-scoreLifestyle interventionLive birthsLive birth rateMetabolic syndrome parametersZ-scoreMetabolic syndromeUnexplained infertilityIntrauterine inseminationOvarian stimulationSyndrome parametersMetabolic parametersObese WomenBirth outcomesLive birth outcomesIntervention phaseImprove metabolic syndromeSecondary analysisFisher's exact testStudy participantsZ-score differenceLifestyle modificationStudent's t-testBirth rateLogistic regressionTENSOR QUANTILE REGRESSION WITH LOW-RANK TENSOR TRAIN ESTIMATION.
Liu Z, Lee C, Zhang H. TENSOR QUANTILE REGRESSION WITH LOW-RANK TENSOR TRAIN ESTIMATION. The Annals Of Applied Statistics 2024, 18: 1294-1318. PMID: 38682044, PMCID: PMC11046526, DOI: 10.1214/23-aoas1835.Peer-Reviewed Original ResearchTensor trainCoefficient tensorRate of convergenceLow-rankQuantile regression frameworkApproximation-based methodVariation penaltyHuman intelligenceQuantile regression modelEstimation algorithmMRI image dataAsymptotic normalityArray of imagesScalar outcomeEmpirical performanceImage dataTrained estimatorDimensionalityNumerical studyMagnetic resonance imaging imagesQuantile regressionTensorRegression frameworkTT estimationImagesCost-effectiveness analysis of expectant vs active management for treatment of persistent pregnancies of unknown location
WALTER J, BARNHART K, KOELPER N, SANTORO N, ZHANG H, THOMAS T, HUANG H, HARVIE H, Network E. Cost-effectiveness analysis of expectant vs active management for treatment of persistent pregnancies of unknown location. American Journal Of Obstetrics And Gynecology 2024, 231: 328.e1-328.e11. PMID: 38552817, DOI: 10.1016/j.ajog.2024.03.035.Peer-Reviewed Original ResearchQuality-adjusted life yearsTwo-dose methotrexateUterine evacuationExpectant managementIncremental cost-effectiveness ratioPersistent pregnancyCost-effectiveness ratioSurgical managementCost-effectiveness acceptability curvesPersistent pregnancy of unknown locationLife yearsLower-risk patient populationsSerum human chorionic gonadotropinPregnancies of unknown locationLaparoscopic surgical managementRate of salpingectomyManagement of pregnancyMean quality-adjusted life yearsMulticenter randomized trialRisk patient populationLower mean costsCosts of surgical interventionsHuman chorionic gonadotropinLower quality-adjusted life yearsAcceptability curvesHeterogeneity Analysis on Multi-State Brain Functional Connectivity and Adolescent Neurocognition
Wang S, Constable T, Zhang H, Zhao Y. Heterogeneity Analysis on Multi-State Brain Functional Connectivity and Adolescent Neurocognition. Journal Of The American Statistical Association 2024, 119: 851-863. PMID: 39371422, PMCID: PMC11451334, DOI: 10.1080/01621459.2024.2311363.Peer-Reviewed Original ResearchHow to minimize the dropout and crossover in an infertility trial?
Huang H, Kuang H, Thomas T, Wei D, Zhang H. How to minimize the dropout and crossover in an infertility trial? Fertility And Sterility 2024, 121: 905-908. PMID: 38316206, DOI: 10.1016/j.fertnstert.2024.01.035.Peer-Reviewed Original ResearchTowards precision oncology discovery: four less known genes and their unknown interactions as highest-performed biomarkers for colorectal cancer
Liu Y, Xu Y, Li X, Chen M, Wang X, Zhang N, Zhang H, Zhang Z. Towards precision oncology discovery: four less known genes and their unknown interactions as highest-performed biomarkers for colorectal cancer. Npj Precision Oncology 2024, 8: 13. PMID: 38243058, PMCID: PMC10799029, DOI: 10.1038/s41698-024-00512-1.Peer-Reviewed Original ResearchFibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids
Al-Hendy A, Segars J, Taylor H, González F, Siblini H, Zamah M, Alkelani H, Singh B, Flores V, Christman G, Johnson J, Huang H, Zhang H. Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids. BMJ Open 2024, 14: e078989. PMID: 38216200, PMCID: PMC10806662, DOI: 10.1136/bmjopen-2023-078989.Peer-Reviewed Original ResearchConceptsUnexplained infertilityIntrauterine inseminationInstitutional review boardCumulative live birth rateUterine fibroidsLive birth rateCause of infertilityFood and Drug AdminstrationGonadotropin hormone-releasing hormoneGreen tea extractDouble-blind clinical trialNon-surgical treatment optionsTimed intrauterine inseminationUterine fibroid sizeOvarian stimulationQuality of Life Questionnaire scoresHormone-releasing hormoneLocal institutional review boardInfertility treatmentNational Institute of Child HealthInstitute of Child HealthMiscarriage rateBirth rateReproductive-age womenEndometrial qualityOptimal and Safe Estimation for High-Dimensional Semi-Supervised Learning
Deng S, Ning Y, Zhao J, Zhang H. Optimal and Safe Estimation for High-Dimensional Semi-Supervised Learning. Journal Of The American Statistical Association 2024, 119: 2748-2759. PMID: 40078670, PMCID: PMC11902906, DOI: 10.1080/01621459.2023.2277409.Peer-Reviewed Original ResearchSemi-supervised estimatorConditional mean functionMean functionSupervised estimationParameters of linear modelsSemi-supervised learningRegression parametersEstimation problemLinear modelSupplementary materialsTheoretical resultsParameter estimationSemi-supervised settingUnlabeled dataLabeled dataEstimationMinimaxMisspecificationNumerical simulationsDataFunctionLearningProblemData analysisUse of random integration to test equality of high dimensional covariance matrices.
Jiang Y, Wen C, Jiang Y, Wang X, Zhang H. Use of random integration to test equality of high dimensional covariance matrices. Statistica Sinica 2024, 33: 2359-2380. PMID: 37799490, PMCID: PMC10550010, DOI: 10.5705/ss.202020.0486.Peer-Reviewed Original Research
2023
Nonparametric Statistical Inference via Metric Distribution Function in Metric Spaces
Wang X, Zhu J, Pan W, Zhu J, Zhang H. Nonparametric Statistical Inference via Metric Distribution Function in Metric Spaces. Journal Of The American Statistical Association 2023, 119: 2772-2784. PMID: 40078669, PMCID: PMC11902916, DOI: 10.1080/01621459.2023.2277417.Peer-Reviewed Original ResearchMetric spaceStatistical inferenceGlivenko-CantelliCorrespondence theoremEuclidean spaceGlivenko-Cantelli theoremDistribution functionNonparametric statistical inferenceDonsker propertyProbability measuresGeneral spaceRandom objectsTheoremMeasurement theorySupplementary materialsEuclideanSpaceIndependence testInferenceDonskerCorrespondenceNonparametricHypercubeMetricsFunctionIdentification and validation of supervariants reveal novel loci associated with human white matter microstructure
Wang S, Li T, Zhao B, Dai W, Yao Y, Li C, Li T, Zhu H, Zhang H. Identification and validation of supervariants reveal novel loci associated with human white matter microstructure. Genome Research 2023, 34: gr.277905.123. PMID: 38190638, PMCID: PMC10904010, DOI: 10.1101/gr.277905.123.Peer-Reviewed Original ResearchASSOCIATION OF FOLLICULAR PHASE LENGTH (FPL) AND EARLY PREGNANCY LOSS (EPL) IN WOMEN WITH UNEXPLAINED INFERTILITY UNDERGOING OVARIAN STIMULATION WITH INTRAUTERINE INSEMINATION (OS-IUI) CYCLES
Hosseinzadeh P, Schone E, Peck J, Craig L, Zhang H, Legro R, Diamond M, Santoro N, Hansen K. ASSOCIATION OF FOLLICULAR PHASE LENGTH (FPL) AND EARLY PREGNANCY LOSS (EPL) IN WOMEN WITH UNEXPLAINED INFERTILITY UNDERGOING OVARIAN STIMULATION WITH INTRAUTERINE INSEMINATION (OS-IUI) CYCLES. Fertility And Sterility 2023, 120: e170-e171. DOI: 10.1016/j.fertnstert.2023.08.507.Peer-Reviewed Original Research
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