2025
Monitoring molecular markers associated with antimalarial drug resistance in south-east Senegal from 2021 to 2023
Wade A, Sene S, Caspar E, Diallo F, Platon L, Thiebaut L, Pouye M, Ba A, Thiam L, Fall M, Sadio B, Desamours I, Guerra N, Hagadorn K, Amambua-Ngwa A, Bei A, Vigan-Womas I, Ménard D, Mbengue A. Monitoring molecular markers associated with antimalarial drug resistance in south-east Senegal from 2021 to 2023. Journal Of Antimicrobial Chemotherapy 2025, 80: 828-839. PMID: 39846779, PMCID: PMC11879165, DOI: 10.1093/jac/dkaf006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntimalarialsArtemisininsChildChild, PreschoolDrug CombinationsDrug ResistanceFemaleHumansMalaria, FalciparumMaleMembrane Transport ProteinsMiddle AgedMultidrug Resistance-Associated ProteinsMutationPlasmodium falciparumProtozoan ProteinsPyrimethamineSenegalSulfadoxineTetrahydrofolate DehydrogenaseYoung AdultConceptsArtemisinin-based combination therapyMolecular markers associated with antimalarial drug resistanceArtemisinin-based combination therapy efficacyP. falciparum infectionSulfadoxine-pyrimethamine resistanceAntimalarial drug resistanceInvestigated gene polymorphismsCQ-RResistance in vitroVenous blood samplesClinical outcome studiesI356TK76TPfcrt mutationsChloroquine resistanceAntimalarial resistancePfmdr-1CQ useMalaria eliminationCombination therapyResistance surveillanceGene polymorphismsPlasmodium falciparumDrug resistanceAmplicon deep sequencing
2018
Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance
Bei AK, Niang M, Deme AB, Daniels RF, Sarr FD, Sokhna C, Talla C, Faye J, Diagne N, Doucoure S, Mboup S, Wirth DF, Tall A, Ndiaye D, Hartl DL, Volkman SK, Toure-Balde A. Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance. The Journal Of Infectious Diseases 2018, 217: 622-627. PMID: 29325146, PMCID: PMC6279132, DOI: 10.1093/infdis/jix580.Peer-Reviewed Original Research
2017
High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations
Ndiaye YD, Diédhiou CK, Bei AK, Dieye B, Mbaye A, Mze NP, Daniels RF, Ndiaye IM, Déme AB, Gaye A, Sy M, Ndiaye T, Badiane AS, Ndiaye M, Premji Z, Wirth DF, Mboup S, Krogstad D, Volkman SK, Ahouidi AD, Ndiaye D. High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations. Malaria Journal 2017, 16: 153. PMID: 28420422, PMCID: PMC5395743, DOI: 10.1186/s12936-017-1811-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolDihydropteroate SynthaseDrug ResistanceGenotypeGenotyping TechniquesHumansMalaria, FalciparumMolecular Diagnostic TechniquesPlasmodiumPoint-of-Care SystemsPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthSenegalTanzaniaTetrahydrofolate DehydrogenaseTransition TemperatureYoung AdultConceptsMalaria endemic sitesDrug resistanceHigh prevalenceUncomplicated Plasmodium falciparum malariaPolymerase chain reaction-restriction fragment length polymorphism methodologyAnti-malarial drug usePlasmodium falciparum malariaEndemic sitesEmergence of resistanceMultiplicity of infectionFalciparum malariaFragment length polymorphism methodologyDHFR mutationsBlood samplesMalaria endemicityPCR-RFLP genotypingPCR/RFLPTreatment policyCodon 540Drug usePlasmodium populationsMixed allelesEarly detectionCodons 51Mixed infectionsContinued Transmission of Zika Virus in Humans in West Africa, 1992–2016
Herrera BB, Chang CA, Hamel DJ, Mboup S, Ndiaye D, Imade G, Okpokwu J, Agbaji O, Bei AK, Kanki PJ. Continued Transmission of Zika Virus in Humans in West Africa, 1992–2016. The Journal Of Infectious Diseases 2017, 215: 1546-1550. PMID: 28398562, PMCID: PMC5853591, DOI: 10.1093/infdis/jix182.Peer-Reviewed Original Research
2013
Inhibitory Humoral Responses to the Plasmodium falciparum Vaccine Candidate EBA-175 Are Independent of the Erythrocyte Invasion Pathway
Badiane AS, Bei AK, Ahouidi AD, Patel SD, Salinas N, Ndiaye D, Sarr O, Ndir O, Tolia NH, Mboup S, Duraisingh MT. Inhibitory Humoral Responses to the Plasmodium falciparum Vaccine Candidate EBA-175 Are Independent of the Erythrocyte Invasion Pathway. MSphere 2013, 20: 1238-1245. PMID: 23761656, PMCID: PMC3754519, DOI: 10.1128/cvi.00135-13.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayEBA-175Human antibodiesAffinity-purified human antibodiesBlood-stage vaccine candidateParasite strainsSialic acid-dependent mannerParasite invasionPresence of antibodiesErythrocyte-binding domainMultiple ligand-receptor interactionsEx vivo assaysPooled patient plasmaSenegalese parasitesAlternative invasion pathwaysHumoral responseVaccine candidatesPatient plasmaSenegalese patientsLigand-receptor interactionsClinical isolatesInvasion inhibitionVaccine designEx vivoFunctional inhibition
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