2024
Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes
Rogne T, Gill D, Liew Z, Shi X, Stensrud V, Nilsen T, Burgess S. Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes. JAMA Network Open 2024, 7: e2351166. PMID: 38206626, PMCID: PMC10784860, DOI: 10.1001/jamanetworkopen.2023.51166.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightCholesterolCohort StudiesDiabetes Mellitus, Type 2Educational StatusFemaleGenome-Wide Association StudyHumansHyperemesis GravidarumInfant, NewbornLipoproteins, HDLMediation AnalysisMendelian Randomization AnalysisPre-EclampsiaPregnancyPregnancy OutcomePregnancy, EctopicPremature BirthConceptsCardiometabolic risk factorsBody mass indexOffspring birth weightEducational attainmentMendelian randomizationHigh-density lipoprotein cholesterol levelsSystolic blood pressureInverse variance-weighted methodModifiable cardiometabolic risk factorsPregnancy outcomesCohort studyLipoprotein cholesterol levelsMR-Egger regressionMass indexUnivariable MR analysisEffects of educational attainmentAssociated with increased risk of adverse pregnancy outcomesPublic health interventionsMaternal education levelLower educational attainmentRisk factorsRisk of adverse pregnancy outcomesGenome-wide association studiesAssociated with increased riskBirth weight
2023
Season of Conception and Risk of Cerebral Palsy
Zhuo H, Ritz B, Warren J, Liew Z. Season of Conception and Risk of Cerebral Palsy. JAMA Network Open 2023, 6: e2335164. PMID: 37738049, PMCID: PMC10517373, DOI: 10.1001/jamanetworkopen.2023.35164.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral PalsyChildCohort StudiesFemaleHumansInfant, NewbornMaleMothersPremature BirthSeasonsConceptsCerebral palsySeason of conceptionCalifornia birth recordsCohort studyPreterm birthRelative riskBirth recordsRisk of CPStatewide cohort studyEtiological risk factorsHigher Social Vulnerability IndexLength of gestationDiagnostic recordsNeighborhood-level factorsSummer conceptionsRisk factorsStratified analysisLive birthsMAIN OUTCOMEHigh riskCP riskPoisson regressionCP statusDevelopmental servicesNeuromotor disabilitiesExposure to per- and polyfluoroalkyl substances in early pregnancy and risk of cerebral palsy in children
Vilhelmsson A, Rylander L, Jöud A, Lindh C, Mattsson K, Liew Z, Guo P, Ritz B, Källén K, Thacher J. Exposure to per- and polyfluoroalkyl substances in early pregnancy and risk of cerebral palsy in children. The Science Of The Total Environment 2023, 899: 165622. PMID: 37474063, DOI: 10.1016/j.scitotenv.2023.165622.Peer-Reviewed Original ResearchConceptsOdds ratioPreterm infantsEarly pregnancyPerfluorononanoic acidPrenatal PFAS exposureMaternal serum concentrationsCerebral palsy casesConfidence intervalsCase-control studyRisk of CPEnvironmental risk factorsPositive associationContinuous variablesHigh PFASPalsy casesBirth RegistryPreterm controlsCerebral palsyLifestyle factorsPreterm casesUnexplained etiologyPrenatal exposureSerum concentrationsRisk factorsPerfluorooctane sulfonateResidential proximity to unconventional oil and gas development and birth defects in Ohio
Gaughan C, Sorrentino K, Liew Z, Johnson N, Clark C, Soriano M, Plano J, Plata D, Saiers J, Deziel N. Residential proximity to unconventional oil and gas development and birth defects in Ohio. Environmental Research 2023, 229: 115937. PMID: 37076028, PMCID: PMC10198955, DOI: 10.1016/j.envres.2023.115937.Peer-Reviewed Original ResearchMeSH KeywordsChildCohort StudiesFemaleHumansInfant, NewbornMaleNatural GasNeural Tube DefectsOhioParturitionPregnancyConceptsNeural tube defectsCertain birth defectsBirth defectsOdds ratioRegistry-based cohort studyTube defectsConfidence intervalsResidential proximityState birth recordsBirth defect typeState surveillance systemsMaternal residential proximityLimb reduction defectsCohort studyUnexposed mothersStructural birth defectsLive birthsInfant sexBirth recordsSpina bifidaReduction defectsFemale offspringDevelopmental toxicantsExposure metrics
2022
Parental Age and Childhood Risk for Cerebral Palsy in California
Zhou L, Meng Q, von Ehrenstein O, Xiao J, Gao Y, Wu Y, Ritz B, Liew Z. Parental Age and Childhood Risk for Cerebral Palsy in California. The Journal Of Pediatrics 2022, 255: 147-153.e6. PMID: 36372095, PMCID: PMC10121738, DOI: 10.1016/j.jpeds.2022.10.039.Peer-Reviewed Original ResearchConceptsCerebral palsyPaternal ageGreater riskPreterm birthMaternal ageParental ageRisk of CPYoung maternal ageBirth certificate recordsCase-control studyTime of deliveryChildren of mothersOlder paternal ageCP diagnosisPreterm deliveryOffspring riskCertificate recordsCP casesCP riskSingleton controlsAge 20Older mothersAge 25Older ageChildhood risk
2018
Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort
Meng Q, Inoue K, Ritz B, Olsen J, Liew Z. Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort. International Journal Of Environmental Research And Public Health 2018, 15: 1832. PMID: 30149566, PMCID: PMC6164159, DOI: 10.3390/ijerph15091832.Peer-Reviewed Original ResearchConceptsDanish National Birth CohortLow birth weightNational Birth CohortBirth weightPreterm birthBirth outcomesPFASs exposureBirth cohortPrenatal PFASs exposureMaternal plasma concentrationsAdverse birth outcomesPerfluorononanoic acidPerfluorodecanoic acidWidespread industrial pollutantsPerfluoroalkyl substancesPerfluorooctanoate exposureGestational ageHighest quartileInfant pairsEarly pregnancyFetal growthPrenatal exposurePerfluoroheptane sulfonatePlasma concentrationsElevated riskDevelopmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes
Liew Z, Goudarzi H, Oulhote Y. Developmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes. Current Environmental Health Reports 2018, 5: 1-19. PMID: 29556975, PMCID: PMC6348874, DOI: 10.1007/s40572-018-0173-4.Peer-Reviewed Original ResearchConceptsHealth outcomesPostnatal growthAssociated health outcomesPurpose of ReviewWePerfluoroalkyl substancesPlacenta transferBirth outcomesPotential health effectsPostnatal exposureImmunomodulatory effectsPrenatal exposureEpidemiological evidenceEpidemiological findingsDevelopmental exposureImmune functionAnimal studiesPossible associationNeurodevelopmental endpointsAdverse effectsHealth effectsHuman exposureOutcomesExposureBreastfeedingHome environment
2015
Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study
Liew Z, Ritz B, Virk J, Olsen J. Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study. Autism Research 2015, 9: 951-958. PMID: 26688372, DOI: 10.1002/aur.1591.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderChildChild, PreschoolCohort StudiesComorbidityDenmarkFemaleHumansInfantInfant, NewbornMalePregnancyPrenatal Exposure Delayed EffectsProportional Hazards ModelsProspective StudiesRiskStatistics as TopicConceptsRisk of ASDHyperkinetic symptomsAcetaminophen useHazard ratioDanish National Birth CohortCox proportional hazards modelHyperactive behavioral phenotypesAutism spectrum disorderEnd of followNational Birth CohortComputer-assisted telephone interviewsProportional hazards modelInfantile autismConfident intervalFever medicationPsychiatric RegistryPrenatal useProspective dataMaternal useHyperkinetic disorderAcetaminophen exposureFetal lifeHazards modelDiagnosis of ASDBirth cohort
2014
Prenatal Exposure to Perfluoroalkyl Substances and the Risk of Congenital Cerebral Palsy in Children
Liew Z, Ritz B, Bonefeld-Jørgensen EC, Henriksen TB, Nohr EA, Bech BH, Fei C, Bossi R, von Ehrenstein OS, Streja E, Uldall P, Olsen J. Prenatal Exposure to Perfluoroalkyl Substances and the Risk of Congenital Cerebral Palsy in Children. American Journal Of Epidemiology 2014, 180: 574-581. PMID: 25139206, DOI: 10.1093/aje/kwu179.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlkanesulfonic AcidsCaprylatesCase-Control StudiesCerebral PalsyCohort StudiesDenmarkEndocrine DisruptorsEnvironmental MonitoringEnvironmental PollutantsFemaleFluorocarbonsHumansInfant, NewbornMaleMaternal AgeOdds RatioPregnancyPrenatal Exposure Delayed EffectsSex DistributionSex FactorsYoung AdultConceptsCongenital cerebral palsyPrenatal exposureCerebral palsyDanish National Birth CohortCerebral Palsy RegisterNational Birth CohortFetal brain developmentDose-response patternCase-cohort designPerfluoroalkyl substancesLiveborn singletonsMaternal levelsRisk ratioHigh riskCP casesCP riskBirth cohortMaternal plasmaBrain developmentPalsyPerfluorooctane sulfonateRiskPFAS levelsCohortPerfluorooctanoic acid