Attention Deficit/Hyperactivity Disorder and Childhood Autism in Association with Prenatal Exposure to Perfluoroalkyl Substances: A Nested Case–Control Study in the Danish National Birth Cohort
Liew Z, Ritz B, von Ehrenstein OS, Bech BH, Nohr EA, Fei C, Bossi R, Henriksen TB, Bonefeld-Jørgensen EC, Olsen J. Attention Deficit/Hyperactivity Disorder and Childhood Autism in Association with Prenatal Exposure to Perfluoroalkyl Substances: A Nested Case–Control Study in the Danish National Birth Cohort. Environmental Health Perspectives 2014, 123: 367-373. PMID: 25616253, PMCID: PMC4383573, DOI: 10.1289/ehp.1408412.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderDanish National Birth CohortNational Birth CohortDeficit/hyperactivity disorderPrenatal exposureRisk ratioChildhood autismBirth cohortDanish National Hospital RegistryDanish Psychiatric Central RegistryNested Case-Control StudyRisk of ADHDNational Hospital RegistryPrenatal PFAS exposureHyperactivity disorderCase-control studyMother-child pairsPerfluoroalkyl substancesConsistent evidenceHospital registryProspective studyPlasma levelsNeurobehavioral problemsPFAS exposureCentral RegistryAcetaminophen Use During Pregnancy, Behavioral Problems, and Hyperkinetic Disorders
Liew Z, Ritz B, Rebordosa C, Lee PC, Olsen J. Acetaminophen Use During Pregnancy, Behavioral Problems, and Hyperkinetic Disorders. JAMA Pediatrics 2014, 168: 313-320. PMID: 24566677, DOI: 10.1001/jamapediatrics.2013.4914.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAttention Deficit Disorder with HyperactivityChildChild, PreschoolDenmarkFemaleHumansHyperkinesisInfantMaleMental DisordersMothersPregnancyPrenatal Exposure Delayed EffectsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSurveys and QuestionnairesConceptsAcetaminophen useHyperkinetic disorderADHD-like behaviorsMental health problemsPrenatal exposureADHD medicationHigh riskDanish National Hospital RegistryDanish Psychiatric Central RegistryDanish National Birth CohortBehavioral problemsMothers' mental health problemsDanish Prescription RegistryMaternal acetaminophen useNational Hospital RegistryNational Birth CohortExposure-response trendsComputer-assisted telephone interviewsFetal brain developmentAge 7 yearsChildren 7 yearsAttention-deficit/hyperactivity disorderPublic health relevanceADHD prescriptionsMaternal inflammation