Genetically altered mice to evaluate glutathione homeostasis in health and disease
Dalton TP, Chen Y, Schneider SN, Nebert DW, Shertzer HG. Genetically altered mice to evaluate glutathione homeostasis in health and disease. Free Radical Biology And Medicine 2004, 37: 1511-1526. PMID: 15477003, DOI: 10.1016/j.freeradbiomed.2004.06.040.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRole of GSHGSH biosynthetic pathwayCell model systemBiosynthetic pathwayExogenous electrophilesGSH homeostasisCellular GSHHuman diseasesGlutathione homeostasisMouse modelGSH synthesisTripeptide glutathioneAntioxidant systemOxidative damageGenetic deficiencyModel systemOxidative stressHomeostasisSuch chemicalsGSHDisease processNonspecific effects