2024
Autoimmune Diseases and Risk of Non‐Hodgkin Lymphoma: A Mendelian Randomisation Study
Shi X, Wallach J, Ma X, Rogne T. Autoimmune Diseases and Risk of Non‐Hodgkin Lymphoma: A Mendelian Randomisation Study. Cancer Medicine 2024, 13: e70327. PMID: 39506244, PMCID: PMC11540836, DOI: 10.1002/cam4.70327.Peer-Reviewed Original ResearchConceptsRisk of non-Hodgkin lymphomaNon-Hodgkin's lymphomaAutoimmune diseasesMendelian randomisationType 1 diabetesAssociated with risk of non-Hodgkin lymphomaWeak instrument biasNon-Hodgkin lymphoma subtypesTwo-sample MRNon-Hodgkin lymphoma riskRisk factorsSusceptibility to type 1 diabetesMendelian randomisation studiesCohorts of European ancestryAssociated with riskNo significant associationPotential pleiotropyPotential risk factorsUK BiobankFinnGen studyNon-HodgkinHaematological malignanciesRandomised studyEuropean ancestrySignificant associationHigh ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancyMediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes
Rogne T, Gill D, Liew Z, Shi X, Stensrud V, Nilsen T, Burgess S. Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes. JAMA Network Open 2024, 7: e2351166. PMID: 38206626, PMCID: PMC10784860, DOI: 10.1001/jamanetworkopen.2023.51166.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightCholesterolCohort StudiesDiabetes Mellitus, Type 2Educational StatusFemaleGenome-Wide Association StudyHumansHyperemesis GravidarumInfant, NewbornLipoproteins, HDLMediation AnalysisMendelian Randomization AnalysisPre-EclampsiaPregnancyPregnancy OutcomePregnancy, EctopicPremature BirthConceptsCardiometabolic risk factorsBody mass indexOffspring birth weightEducational attainmentMendelian randomizationHigh-density lipoprotein cholesterol levelsSystolic blood pressureInverse variance-weighted methodModifiable cardiometabolic risk factorsPregnancy outcomesCohort studyLipoprotein cholesterol levelsMR-Egger regressionMass indexUnivariable MR analysisEffects of educational attainmentAssociated with increased risk of adverse pregnancy outcomesPublic health interventionsMaternal education levelLower educational attainmentRisk factorsRisk of adverse pregnancy outcomesGenome-wide association studiesAssociated with increased riskBirth weight
2023
Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort
Grønseth S, Rogne T, Heggelund L, Åsvold B, Afset J, Damås J. Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort. International Journal Of Infectious Diseases 2023, 134: 177-186. PMID: 37339716, DOI: 10.1016/j.ijid.2023.06.013.Peer-Reviewed Original ResearchConceptsCharlson Comorbidity IndexHIV-negative patientsPneumocystis pneumoniaRisk stratificationFungal burdenMulticenter cohortPolymerase chain reactionAbnormal leukocyte countComorbid cardiovascular diseaseLow serum albuminBronchoalveolar lavage fluidC-reactive proteinChain reactionHigher fungal burdenReal-time polymerase chain reactionProbable Pneumocystis pneumoniaCycle threshold valuesComorbidity indexCorticosteroid useLavage fluidSemiquantitative real-time polymerase chain reactionLeukocyte countImmunological disordersCardiovascular diseaseRetrospective analysisMendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia
Rogne T, DeWan A, Metayer C, Wiemels J, Ma X. Mendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101058. PMID: 37330008, DOI: 10.1016/j.ajogmf.2023.101058.Peer-Reviewed Original ResearchDyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibitionCirculating levels of micronutrients and risk of infections: a Mendelian randomization study
Flatby H, Ravi A, Damås J, Solligård E, Rogne T. Circulating levels of micronutrients and risk of infections: a Mendelian randomization study. BMC Medicine 2023, 21: 84. PMID: 36882828, PMCID: PMC9993583, DOI: 10.1186/s12916-023-02780-3.Peer-Reviewed Original ResearchConceptsRisk of infectionGastrointestinal infectionsBlood levelsMendelian randomizationMendelian randomization studyOdds ratioObservational studyImmune responseIndependent cohortRandomization studySignificant associationInfectionClear associationMR analysisLevels of micronutrientsStatistical significanceConclusionsOur resultsPrevious observational studiesStandard deviation increaseUK BiobankRiskLevels of copperEuropean ancestryAvailable summary statisticsAssociationSex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study
Ardissino M, Slob E, Carter P, Rogne T, Girling J, Burgess S, Ng F. Sex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study. Journal Of The American Heart Association 2023, 12: e027933. PMID: 36846989, PMCID: PMC10111460, DOI: 10.1161/jaha.122.027933.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseBody mass indexHeart failureCardiovascular diseaseReproductive factorsArtery diseaseIschemic strokeMass indexAtrial fibrillationLive birthsFirst birthCardiovascular disease riskType 2 diabetesBackground Observational studiesMendelian randomizationMendelian randomization studyModifiable mediatorsBlood pressureResidual confoundingObservational studyPrimary analysisRandomization studyDisease riskStrokeClinical interventionsOutdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers
Zhong C, Wang R, Morimoto L, Longcore T, Franklin M, Rogne T, Metayer C, Wiemels J, Ma X. Outdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers. Scientific Reports 2023, 13: 583. PMID: 36631468, PMCID: PMC9834257, DOI: 10.1038/s41598-022-23682-z.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaRisk of childhoodEarly-onset cancersLymphoblastic leukemiaBirth recordsChildhood acute lymphoblastic leukemiaNon-Hispanic white childrenHispanic childrenCalifornia Cancer RegistryEtiology of childhoodOutdoor artificial lightOutdoor ALANHighest tertileCancer RegistryLinkage studiesRisk factorsBorderline associationElevated riskCancer diagnosisCancerEnvironmental exposuresWhite childrenCommon typeAir pollutionRisk
2022
Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study
Mohus RM, Flatby H, Liyanarachi KV, DeWan AT, Solligård E, Damås JK, Åsvold BO, Gustad LT, Rogne T. Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study. Scientific Reports 2022, 12: 16157. PMID: 36171422, PMCID: PMC9516524, DOI: 10.1038/s41598-022-20679-6.Peer-Reviewed Original ResearchConceptsRisk of sepsisTwo-sample Mendelian randomization studyIron statusMendelian randomization studySerum ironOdds ratioCOVID-19Randomization studyTotal iron binding capacitySevere COVID-19Risk of hospitalizationHigh iron statusIron binding capacitySex-stratified analysesTransferrin saturationSevere infectionsIron biomarkersObservational studyHigh riskSepsisStandard deviation increaseHospitalizationFurther studiesRiskStatusInsomnia symptoms and risk of bloodstream infections: prospective data from the prospective population‐based Nord‐Trøndelag Health Study (HUNT), Norway
Thorkildsen MS, Laugsand LE, Nilsen TIL, Mohus RM, Høvik LH, Rogne T, Solligård E, Damås JK, Gustad LT. Insomnia symptoms and risk of bloodstream infections: prospective data from the prospective population‐based Nord‐Trøndelag Health Study (HUNT), Norway. Journal Of Sleep Research 2022, 32: e13696. PMID: 36068650, PMCID: PMC10078600, DOI: 10.1111/jsr.13696.Peer-Reviewed Original ResearchConceptsFirst-time bloodstream infectionNord-Trøndelag Health StudyHazard ratioBloodstream infectionsInsomnia symptomsProspective dataHealth StudyConfidence intervalsNorwegian Nord-Trøndelag Health StudyRisk of BSIPopulation-based prospective studyPopulation-based Nord-Trøndelag Health StudyFrequent insomnia symptomsNon-restorative sleepRisk of infectionCox regressionProspective studyAbove symptomsImmune functionSymptomsInfectionMortalitySleepRiskParticipantsIncidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study
Liyanarachi KV, Solligård E, Mohus RM, Åsvold BO, Rogne T, Damås JK. Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study. PLOS ONE 2022, 17: e0271263. PMID: 35819970, PMCID: PMC9275692, DOI: 10.1371/journal.pone.0271263.Peer-Reviewed Original ResearchConceptsSevere bacterial infectionsPositive blood culturesBacterial infectionsBlood culturesPopulation-based HUNT StudyPositive blood culture rateTrøndelag Health StudyUrinary tract infectionPopulation-based cohortBlood culture rateCommon infectious diseasesInfectious disease burdenRegistry linkageTract infectionsLoss of healthMedian timeHUNT StudyDisease burdenIncidence rateCulture rateGeneral populationHealth StudyHospitalizationImportant causeTotal burdenExplaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway
Mohus RM, Gustad LT, Furberg AS, Moen MK, Liyanarachi KV, Askim Å, Åsberg SE, DeWan AT, Rogne T, Simonsen GS, Nilsen TIL, Åsvold BO, Damås JK, Solligård E. Explaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway. Scientific Reports 2022, 12: 8436. PMID: 35589812, PMCID: PMC9118181, DOI: 10.1038/s41598-022-12569-8.Peer-Reviewed Original ResearchConceptsIncident bloodstream infectionCardiovascular risk factorsBloodstream infectionsBSI mortalityRisk factorsHigh riskHealth behaviorsFirst-time bloodstream infectionRisk of BSIPotential modifiable risk factorsPopulation-based HUNT StudyModifiable risk factorsSex differencesHospital recordsProspective studyHUNT StudyExcess riskMediation analysisCausal mediation analysisEffects of sexMortalityComorbiditiesWomenMenRiskSmoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
Hernáez Á, Wootton RE, Page CM, Skåra KH, Fraser A, Rogne T, Magnus P, Njølstad PR, Andreassen OA, Burgess S, Lawlor DA, Magnus MC. Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Fertility And Sterility 2022, 118: 180-190. PMID: 35562204, PMCID: PMC7612999, DOI: 10.1016/j.fertnstert.2022.04.001.Peer-Reviewed Original ResearchConceptsChild Cohort StudyCohort studySmoking intensityNorwegian MotherTobacco useMultivariable regressionGreater smoking intensityEffect of smokingHigher smoking intensityMendelian randomizationSelf-reported informationMendelian randomization analysisNationwide cohortProspective studySmoking cessationMendelian randomization resultsMAIN OUTCOMESmokingInfertilityTrue lackGenetic instrumentsRandomization analysisWomenMenRandomization resultsModifiable risk factors for ectopic pregnancy: a Mendelian randomization study
Rogne T, Liew Z, Hernáez Á, Brumpton BM, Magnus MC. Modifiable risk factors for ectopic pregnancy: a Mendelian randomization study. American Journal Of Obstetrics And Gynecology 2022, 227: 339-341.e4. PMID: 35390318, DOI: 10.1016/j.ajog.2022.03.063.Peer-Reviewed Original ResearchSystemic iron status and maternal pregnancy complications: a Mendelian randomization study
Rogne T, Burgess S, Gill D. Systemic iron status and maternal pregnancy complications: a Mendelian randomization study. International Journal Of Epidemiology 2022, 51: 1024-1027. PMID: 35234877, PMCID: PMC7614592, DOI: 10.1093/ije/dyac037.Peer-Reviewed Original Research
2021
Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations
Flatby HM, Rasheed H, Ravi A, Thomas LF, Liyanarachi KV, Afset JE, DeWan AT, Brumpton BM, Hveem K, Åsvold BO, Simonsen GS, Furberg AS, Damås JK, Solligård E, Rogne T. Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations. Clinical Microbiology And Infection 2021, 28: 732.e1-732.e7. PMID: 34763054, DOI: 10.1016/j.cmi.2021.11.004.Peer-Reviewed Original ResearchConceptsLower respiratory tract infectionsRespiratory tract infectionsMendelian randomization analysisTract infectionsRisk factorsRisk of LRTICardiometabolic risk factorsSystolic blood pressureTrøndelag Health StudyPrevalence of smokingRandomization analysisBody mass indexCause of morbidityPotential risk factorsBlood pressureMass indexSuch hospitalizationsDisease burdenProtective effectHealth StudyIndependent European populationsLifetime smokingGenome-wide association studiesGenetic susceptibilitySmokingSARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
D’Antonio M, Nguyen J, Arthur T, Matsui H, Neale B, Daly M, Ganna A, Stevens C, Pathak G, Andrews S, Kanai M, Cordioli M, Ganna A, Karjalainen J, Pathak G, Polimanti R, Andrews S, Cordioli M, Pirinen M, Kanai M, Harerimana N, Veerapen K, Wolford B, Nguyen H, Solomonson M, Stevens C, Liao R, Chwialkowska K, Trankiem A, Balaconis M, Hayward C, Richmond A, Campbell A, Morris M, Fawns-Ritchie C, Glessner J, Shaw D, Chang X, Polikowski H, Lauren E, Chen H, Wanying Z, Hakonarson H, Porteous D, Below J, North K, McCormick J, Timmers P, Wilson J, Tenesa A, D’Mellow K, Kerr S, Niemi M, Cordioli M, Nkambul L, von Hohenstaufen K, Sobh A, Eltoukhy M, Yassen A, Hegazy M, Okasha K, Eid M, Moahmed H, Shahin D, El-Sherbiny Y, Elhadidy T, Elghafar M, El-Jawhari J, Mohamed A, Elnagdy M, Samir A, Abdel-Aziz M, Khafaga W, El-Lawaty W, Torky M, El-shanshory M, Batini C, Lee P, Shrine N, Williams A, Tobin M, Guyatt A, John C, Packer R, Ali A, Free R, Wang X, Wain L, Hollox E, Venn L, Bee C, Adams E, Niemi M, Niavarani A, Cordioli M, Nkambul L, Sharififard B, Aliannejad R, Amirsavadkouhi A, Naderpour Z, Tadi H, Aleagha A, Ahmadi S, Moghaddam S, Adamsara A, Saeedi M, Abdollahi H, Hosseini A, Chariyavilaskul P, Chamnanphon M, Suttichet T, Shotelersuk V, Pongpanich M, Phokaew C, Chetruengchai W, Jantarabenjakul W, Putchareon O, Torvorapanit P, Puthanakit T, Suchartlikitwong P, Hirankarn N, Nilaratanakul V, Sodsai P, Brumpton B, Hveem K, Willer C, Wolford B, Zhou W, Rogne T, Solligard E, Åsvold B, Abedalthagafi M, Alaamery M, Alqahtani S, Baraka D, Al Harthi F, Alsolm E, Abu Safieh L, Alowayn A, Alqubaishi F, Al Mutairi A, Mangul S, Alshareef A, Sawaji M, Almutairi M, Aljawini N, Albesher N, Arabi Y, Mahmoud E, Khattab A, Halawani R, Alahmadey Z, Albakri J, Felemban W, Suliman B, Hasanato R, Al-Awdah L, Alghamdi J, AlZahrani D, AlJohani S, Al-Afghani H, Alrashed M, AlDhawi N, AlBardis H, Alkwai S, Alswailm M, Almalki F, Albeladi M, Almohammed I, Barhoush E, Albader A, Massadeh S, AlMalik A, Alotaibi S, Alghamdi B, Jung J, Fawzy M, Lee Y, Magnus P, Trogstad L, Helgeland Ø, Harris J, Mangino M, Spector T, Emma D, Smieszek S, Przychodzen B, Polymeropoulos C, Polymeropoulos V, Polymeropoulos M, Fernandez-Cadenas I, Perez-Tur J, Llucià-Carol L, Cullell N, Muiño E, Cárcel-Márquez J, DeDiego M, Iglesias L, Planas A, Soriano A, Rico V, Agüero D, Bedini J, Lozano F, Domingo C, Robles V, Ruiz-Jaén F, Márquez L, Gomez J, Coto E, Albaiceta G, García-Clemente M, Dalmau D, Arranz M, Dietl B, Serra-Llovich A, Soler P, Colobrán R, Martín-Nalda A, Martínez A, Bernardo D, Rojo S, Fiz-López A, Arribas E, de la Cal-Sabater P, Segura T, González-Villa E, Serrano-Heras G, Martí-Fàbregas J, Jiménez-Xarrié E, de Felipe Mimbrera A, Masjuan J, García-Madrona S, Domínguez-Mayoral A, Villalonga J, Menéndez-Valladares P, Chasman D, Buring J, Ridker P, Franco G, Sesso H, Manson J, Chang X, Glessner J, Hakonarson H, Hayward C, Richmond A, Porteous D, Campbell A, Fawns-Ritchie C, Medina-Gomez C, Uitterlinden A, Ikram M, Kristiansson K, Koskelainen S, Perola M, Donner K, Kivinen K, Palotie A, Ripatti S, Ruotsalainen S, Kaunisto M, FinnGen, Nakanishi T, Butler-Laporte G, Forgetta V, Morrison D, Ghosh B, Laurent L, Belisle A, Henry D, Abdullah T, Adeleye O, Mamlouk N, Kimchi N, Afrasiabi Z, Vulesevic N, Bouab M, Guzman C, Petitjean L, Tselios C, Xue X, Schurr E, Afilalo J, Afilalo M, Oliveira M, Brenner B, Lepage P, Ragoussis J, Auld D, Brassard N, Durand M, Chassé M, Kaufmann D, Lathrop G, Mooser V, Richards J, Li R, Adra D, Rahmouni S, Georges M, Moutschen M, Misset B, Darcis G, Guiot J, Guntz J, Azarzar S, Gofflot S, Beguin Y, Claassen S, Malaise O, Huynen P, Meuris C, Thys M, Jacques J, Léonard P, Frippiat F, Giot J, Sauvage A, Von Frenckell C, Belhaj Y, Lambermont B, Niemi M, Cordioli M, Pigazzini S, Nkambule L, Daya M, Shortt J, Rafaels N, Wicks S, Crooks K, Barnes K, Gignoux C, Chavan S, Laisk T, Läll K, Lepamets M, Mägi R, Esko T, Reimann E, Milani L, Alavere H, Metsalu K, Puusepp M, Metspalu A, Naaber P, Laane E, Pesukova J, Peterson P, Kisand K, Tabri J, Allos R, Hensen K, Starkopf J, Ringmets I, Tamm A, Kallaste A, Bochud P, Rivolta C, Bibert S, Quinodoz M, Kamdar D, Boillat N, Nussle S, Albrich W, Suh N, Neofytos D, Erard V, Voide C, FHoGID, RegCOVID, P-PredictUs, SeroCOVID, CRiPSI, de Cid R, Galván-Femenía I, Blay N, Carreras A, Cortés B, Farré X, Sumoy L, Moreno V, Mercader J, Guindo-Martinez M, Torrents D, Kogevinas M, Garcia-Aymerich J, Castaño-Vinyals G, Dobaño C, Renieri A, Mari F, Fallerini C, Daga S, Benetti E, Baldassarri M, Fava F, Frullanti E, Valentino F, Doddato G, Giliberti A, Tita R, Amitrano S, Bruttini M, Croci S, Meloni I, Mencarelli M, Rizzo C, Pinto A, Beligni G, Tommasi A, Di Sarno L, Palmieri M, Carriero M, Alaverdian D, Busani S, Bruno R, Vecchia M, Belli M, Picchiotti N, Sanarico M, Gori M, Furini S, Mantovani S, Ludovisi S, Mondelli M, Castelli F, Quiros-Roldan E, Degli Antoni M, Zanella I, Vaghi M, Rusconi S, Siano M, Montagnani F, Emiliozzi A, Fabbiani M, Rossetti B, Bargagli E, Bergantini L, D’Alessandro M, Cameli P, Bennett D, Anedda F, Marcantonio S, Scolletta S, Franchi F, Mazzei M, Guerrini S, Conticini E, Cantarini L, Frediani B, Tacconi D, Spertilli C, Feri M, Donati A, Scala R, Guidelli L, Spargi G, Corridi M, Nencioni C, Croci L, Bandini M, Caldarelli G, Piacentini P, Desanctis E, Cappelli S, Canaccini A, Verzuri A, Anemoli V, Ognibene A, Pancrazzi A, Lorubbio M, Monforte A, Miraglia F, Girardis M, Venturelli S, Cossarizza A, Antinori A, Vergori A, Gabrieli A, Riva A, Francisci D, Schiaroli E, Paciosi F, Scotton P, Andretta F, Panese S, Scaggiante R, Gatti F, Parisi S, Baratti S, Della Monica M, Piscopo C, Capasso M, Russo R, Andolfo I, Iolascon A, Fiorentino G, Carella M, Castori M, Merla G, Squeo G, Aucella F, Raggi P, Marciano C, Perna R, Bassetti M, Di Biagio A, Sanguinetti M, Masucci L, Valente S, Mandalà M, Giorli A, Salerni L, Zucchi P, Parravicini P, Menatti E, Trotta T, Giannattasio F, Coiro G, Lena F, Coviello D, Mussini C, Martinelli E, Mancarella S, Tavecchia L, Crotti L, Gabbi C, Rizzi M, Maggiolo F, Ripamonti D, Bachetti T, La Rovere M, Sarzi-Braga S, Bussotti M, Ceri S, Pinoli P, Raimondi F, Biscarini F, Stella A, Zguro K, Capitani K, Suardi C, Niemi M, Cordioli M, Pigazzini S, Dei S, Parati G, Ravaglia S, Artuso R, Cordioli M, Pigazzini S, Nkambule L, Bottà G, Di Domenico P, Rancan I, Bianchi A, Romani D, Bergomi P, Catena E, Colombo R, Tanfoni M, Vincenti A, Ferri C, Grassi D, Pessina G, Tumbarello M, Di Pietro M, Sabrina R, Luchi S, Barbieri C, Acquilini D, Andreucci E, Paciosi F, Segala F, Tiseo G, Falcone M, Lista M, Poscente M, De Vivo O, Petrocelli P, Guarnaccia A, Baroni S, Smith A, Boughton A, Li K, LeFaive J, Annis A, Justice A, Mirshahi T, Chittoor G, Josyula N, Kosmicki J, Ferreira M, Leader J, Carey D, Gass M, Horowitz J, Cantor M, Yadav A, Baras A, Abecasis G, van Heel D, Hunt K, Mason D, Huang Q, Finer S, Team G, Trivedi B, Griffiths C, Martin H, Wright J, Trembath R, Soranzo N, Zhao J, Butterworth A, Danesh J, Di Angelantonio E, Boezen L, Deelen P, Claringbould A, Lopera E, Warmerdam R, Vonk J, van Blokland I, Lanting P, Ori A, Zöllner B, Wang J, Beck A, Peloso G, Ho Y, Sun Y, Huffman J, O’Donnell C, Cho K, Tsao P, Gaziano J, Nivard M, de geus E, Bartels M, Hottenga J, Weiss S, Karlson E, Smoller J, Green R, Feng Y, Mercader J, Murphy S, Meigs J, Woolley A, Perez E, Rader D, Verma A, Ritchie M, Li B, Verma S, Lucas A, Bradford Y, Zeberg H, Frithiof R, Hultström M, Niemi M, Cordioli M, Pigazzini S, Lipcsey M, Nkambul L, Tardif N, Rooyackers O, Grip J, Maricic T, Nakanishi T, Butler-Laporte G, Forgetta V, Richards J, Karczewski K, Atkinson E, Kanai M, Tsuo K, Baya N, Turley P, Gupta R, Callier S, Walters R, Palmer D, Sarma G, Solomonson M, Cheng N, Lu W, Bryant S, Churchhouse C, Cusick C, Goldstein J, King D, Zhou W, Seed C, Finucane H, Martin A, Bryant S, Satterstrom F, Wilson D, Armstrong J, Rudkin J, Band G, Earle S, Lin S, Arning N, Crook D, Wyllie D, O’Connell A, Spencer C, Koelling N, Caulfield M, Scott R, Fowler T, Moutsianas L, Kousathanas A, Pasko D, Walker S, Rendon A, Stuckey A, Odhams C, Rhodes D, Chan G, Arumugam P, Ball C, Hong E, Rand K, Girshick A, Guturu H, Baltzell A, Roberts G, Park D, Coignet M, McCurdy S, Knight S, Partha R, Rhead B, Zhang M, Berkowitz N, Gaddis M, Noto K, Ruiz L, Pavlovic M, Sloofman L, Andrews S, Charney A, Beckmann N, Schadt E, Jordan D, Thompson R, Gettler K, Abul-Husn N, Ascolillo S, Buxbaum J, Chaudhary K, Cho J, Itan Y, Kenny E, Belbin G, Sealfon S, Sebra R, Salib I, Collins B, Levy T, Britvan B, Keller K, Tang L, Peruggia M, Hiester L, Niblo K, Aksentijevich A, Labkowsky A, Karp A, Zlatopolsky M, Preuss M, Loos R, Nadkarni G, Do R, Hoggart C, Choi S, Underwood S, O’Reilly P, Huckins L, Zyndorf M, D’Antonio-Chronowska A, Frazer K. SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues. Cell Reports 2021, 37: 110020. PMID: 34762851, PMCID: PMC8563343, DOI: 10.1016/j.celrep.2021.110020.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingComputational BiologyCOVID-19Databases, GeneticEthnicityGene ExpressionGene Expression ProfilingGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansOrgan SpecificityPolymorphism, Single NucleotideQuantitative Trait LociSARS-CoV-2Severity of Illness IndexTranscriptomeConceptsExpression quantitative trait lociGenome-wide association study signalsTissue/cell typesQuantitative trait lociGenetic fine mappingGene expression levelsLoci colocalizeGenomic lociGWAS lociTrait lociFine mappingVariety of tissuesCausal SNPsGene expressionSNP setsStudy signalsLociCell typesSARS-CoV-2 susceptibilityGenetic variantsSuggestive associationExpression levelsTissue typesSNPsCredible setsBody mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
Hernáez Á, Rogne T, Skåra KH, Håberg SE, Page CM, Fraser A, Burgess S, Lawlor DA, Magnus MC. Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Human Reproduction 2021, 36: 3141-3151. PMID: 34668019, PMCID: PMC8600658, DOI: 10.1093/humrep/deab224.Peer-Reviewed Original ResearchConceptsCohort studyBMI valuesMendelian randomization analysisMultivariable regressionGreater oddsMultivariable logistic regression modelSTUDY FUNDING/COMPETINGProject number 262700Risk of subfertilityRandomization analysisBody mass indexChild Cohort StudyPARTICIPANTS/MATERIALSUK National InstituteNational InstituteROLE OF CHANCELogistic regression modelsSelf-reported informationAssisted reproduction technologyObese menObese womenHigher BMILower BMIMass indexUS National InstitutesSemiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients
Grønseth S, Rogne T, Hannula R, Åsvold BO, Afset JE, Damås JK. Semiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients. Microbiology Spectrum 2021, 9: 10.1128/spectrum.00026-21. PMID: 34346746, PMCID: PMC8552647, DOI: 10.1128/spectrum.00026-21.Peer-Reviewed Original ResearchConceptsSemiquantitative real-time PCRPneumocystis pneumoniaReal-time PCRCutoff valuePCP statusHigher fungal loadHematological malignanciesPneumocystis jiroveciiHIV-negative immunocompromised patientsHuman immunodeficiency virus (HIV) infectionLower respiratory tract specimensRisk of PCPSolid organ transplant recipientsFungal loadHIV Pneumocystis pneumoniaImmunodeficiency virus infectionOrgan transplant recipientsSolid organ recipientsHIV-negative individualsPCR-positive patientsSolid organ transplantationRespiratory tract specimensVulnerable patient populationLife-threatening infectionsAcute respiratory syndrome