2024
Autoimmune Diseases and Risk of Non‐Hodgkin Lymphoma: A Mendelian Randomisation Study
Shi X, Wallach J, Ma X, Rogne T. Autoimmune Diseases and Risk of Non‐Hodgkin Lymphoma: A Mendelian Randomisation Study. Cancer Medicine 2024, 13: e70327. PMID: 39506244, PMCID: PMC11540836, DOI: 10.1002/cam4.70327.Peer-Reviewed Original ResearchConceptsRisk of non-Hodgkin lymphomaNon-Hodgkin's lymphomaAutoimmune diseasesMendelian randomisationType 1 diabetesAssociated with risk of non-Hodgkin lymphomaWeak instrument biasNon-Hodgkin lymphoma subtypesTwo-sample MRNon-Hodgkin lymphoma riskRisk factorsSusceptibility to type 1 diabetesMendelian randomisation studiesCohorts of European ancestryAssociated with riskNo significant associationPotential pleiotropyPotential risk factorsUK BiobankFinnGen studyNon-HodgkinHaematological malignanciesRandomised studyEuropean ancestrySignificant associationMediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes
Rogne T, Gill D, Liew Z, Shi X, Stensrud V, Nilsen T, Burgess S. Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes. JAMA Network Open 2024, 7: e2351166. PMID: 38206626, PMCID: PMC10784860, DOI: 10.1001/jamanetworkopen.2023.51166.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightCholesterolCohort StudiesDiabetes Mellitus, Type 2Educational StatusFemaleGenome-Wide Association StudyHumansHyperemesis GravidarumInfant, NewbornLipoproteins, HDLMediation AnalysisMendelian Randomization AnalysisPre-EclampsiaPregnancyPregnancy OutcomePregnancy, EctopicPremature BirthConceptsCardiometabolic risk factorsBody mass indexOffspring birth weightEducational attainmentMendelian randomizationHigh-density lipoprotein cholesterol levelsSystolic blood pressureInverse variance-weighted methodModifiable cardiometabolic risk factorsPregnancy outcomesCohort studyLipoprotein cholesterol levelsMR-Egger regressionMass indexUnivariable MR analysisEffects of educational attainmentAssociated with increased risk of adverse pregnancy outcomesPublic health interventionsMaternal education levelLower educational attainmentRisk factorsRisk of adverse pregnancy outcomesGenome-wide association studiesAssociated with increased riskBirth weight
2023
Mendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia
Rogne T, DeWan A, Metayer C, Wiemels J, Ma X. Mendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101058. PMID: 37330008, DOI: 10.1016/j.ajogmf.2023.101058.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightGestational AgeHumansMendelian Randomization AnalysisPrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsDyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibitionCirculating levels of micronutrients and risk of infections: a Mendelian randomization study
Flatby H, Ravi A, Damås J, Solligård E, Rogne T. Circulating levels of micronutrients and risk of infections: a Mendelian randomization study. BMC Medicine 2023, 21: 84. PMID: 36882828, PMCID: PMC9993583, DOI: 10.1186/s12916-023-02780-3.Peer-Reviewed Original ResearchConceptsRisk of infectionGastrointestinal infectionsBlood levelsMendelian randomizationMendelian randomization studyOdds ratioObservational studyImmune responseIndependent cohortRandomization studySignificant associationInfectionClear associationMR analysisLevels of micronutrientsStatistical significanceConclusionsOur resultsPrevious observational studiesStandard deviation increaseUK BiobankRiskLevels of copperEuropean ancestryAvailable summary statisticsAssociationSex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study
Ardissino M, Slob E, Carter P, Rogne T, Girling J, Burgess S, Ng F. Sex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study. Journal Of The American Heart Association 2023, 12: e027933. PMID: 36846989, PMCID: PMC10111460, DOI: 10.1161/jaha.122.027933.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseBody mass indexHeart failureCardiovascular diseaseReproductive factorsArtery diseaseIschemic strokeMass indexAtrial fibrillationLive birthsFirst birthCardiovascular disease riskType 2 diabetesBackground Observational studiesMendelian randomizationMendelian randomization studyModifiable mediatorsBlood pressureResidual confoundingObservational studyPrimary analysisRandomization studyDisease riskStrokeClinical interventions
2022
Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study
Mohus RM, Flatby H, Liyanarachi KV, DeWan AT, Solligård E, Damås JK, Åsvold BO, Gustad LT, Rogne T. Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study. Scientific Reports 2022, 12: 16157. PMID: 36171422, PMCID: PMC9516524, DOI: 10.1038/s41598-022-20679-6.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCOVID-19FemaleFerritinsGenome-Wide Association StudyHumansIronMaleMendelian Randomization AnalysisPolymorphism, Single NucleotideSepsisTransferrinConceptsRisk of sepsisTwo-sample Mendelian randomization studyIron statusMendelian randomization studySerum ironOdds ratioCOVID-19Randomization studyTotal iron binding capacitySevere COVID-19Risk of hospitalizationHigh iron statusIron binding capacitySex-stratified analysesTransferrin saturationSevere infectionsIron biomarkersObservational studyHigh riskSepsisStandard deviation increaseHospitalizationFurther studiesRiskStatusSmoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
Hernáez Á, Wootton RE, Page CM, Skåra KH, Fraser A, Rogne T, Magnus P, Njølstad PR, Andreassen OA, Burgess S, Lawlor DA, Magnus MC. Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Fertility And Sterility 2022, 118: 180-190. PMID: 35562204, PMCID: PMC7612999, DOI: 10.1016/j.fertnstert.2022.04.001.Peer-Reviewed Original ResearchMeSH KeywordsChildCohort StudiesFathersFemaleHumansInfertilityMaleMendelian Randomization AnalysisMothersPregnancyProspective StudiesSmokingConceptsChild Cohort StudyCohort studySmoking intensityNorwegian MotherTobacco useMultivariable regressionGreater smoking intensityEffect of smokingHigher smoking intensityMendelian randomizationSelf-reported informationMendelian randomization analysisNationwide cohortProspective studySmoking cessationMendelian randomization resultsMAIN OUTCOMESmokingInfertilityTrue lackGenetic instrumentsRandomization analysisWomenMenRandomization resultsModifiable risk factors for ectopic pregnancy: a Mendelian randomization study
Rogne T, Liew Z, Hernáez Á, Brumpton BM, Magnus MC. Modifiable risk factors for ectopic pregnancy: a Mendelian randomization study. American Journal Of Obstetrics And Gynecology 2022, 227: 339-341.e4. PMID: 35390318, DOI: 10.1016/j.ajog.2022.03.063.Peer-Reviewed Original ResearchFemaleGenome-Wide Association StudyHumansMendelian Randomization AnalysisPregnancyPregnancy, EctopicRisk FactorsSystemic iron status and maternal pregnancy complications: a Mendelian randomization study
Rogne T, Burgess S, Gill D. Systemic iron status and maternal pregnancy complications: a Mendelian randomization study. International Journal Of Epidemiology 2022, 51: 1024-1027. PMID: 35234877, PMCID: PMC7614592, DOI: 10.1093/ije/dyac037.Peer-Reviewed Original Research
2021
Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations
Flatby HM, Rasheed H, Ravi A, Thomas LF, Liyanarachi KV, Afset JE, DeWan AT, Brumpton BM, Hveem K, Åsvold BO, Simonsen GS, Furberg AS, Damås JK, Solligård E, Rogne T. Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations. Clinical Microbiology And Infection 2021, 28: 732.e1-732.e7. PMID: 34763054, DOI: 10.1016/j.cmi.2021.11.004.Peer-Reviewed Original ResearchMeSH KeywordsBody Mass IndexGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisRespiratory Tract InfectionsConceptsLower respiratory tract infectionsRespiratory tract infectionsMendelian randomization analysisTract infectionsRisk factorsRisk of LRTICardiometabolic risk factorsSystolic blood pressureTrøndelag Health StudyPrevalence of smokingRandomization analysisBody mass indexCause of morbidityPotential risk factorsBlood pressureMass indexSuch hospitalizationsDisease burdenProtective effectHealth StudyIndependent European populationsLifetime smokingGenome-wide association studiesGenetic susceptibilitySmokingBody mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
Hernáez Á, Rogne T, Skåra KH, Håberg SE, Page CM, Fraser A, Burgess S, Lawlor DA, Magnus MC. Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Human Reproduction 2021, 36: 3141-3151. PMID: 34668019, PMCID: PMC8600658, DOI: 10.1093/humrep/deab224.Peer-Reviewed Original ResearchMeSH KeywordsAdultBody Mass IndexChildCohort StudiesFathersFemaleHumansInfertilityMaleMendelian Randomization AnalysisMothersPregnancyConceptsCohort studyBMI valuesMendelian randomization analysisMultivariable regressionGreater oddsMultivariable logistic regression modelSTUDY FUNDING/COMPETINGProject number 262700Risk of subfertilityRandomization analysisBody mass indexChild Cohort StudyPARTICIPANTS/MATERIALSUK National InstituteNational InstituteROLE OF CHANCELogistic regression modelsSelf-reported informationAssisted reproduction technologyObese menObese womenHigher BMILower BMIMass indexUS National InstitutesRelationship Between Blood Pressure and Incident Cardiovascular Disease
Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D. Relationship Between Blood Pressure and Incident Cardiovascular Disease. Hypertension 2021, 77: 2004-2013. PMID: 33813844, PMCID: PMC8115430, DOI: 10.1161/hypertensionaha.120.16534.Peer-Reviewed Original ResearchBlood PressureCardiovascular DiseasesFemaleHumansIncidenceMaleMendelian Randomization AnalysisMiddle Aged
2020
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne T, Solligård E, Burgess S, Brumpton BM, Paulsen J, Prescott HC, Mohus RM, Gustad LT, Mehl A, Åsvold BO, DeWan AT, Damås JK. Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study. PLOS Medicine 2020, 17: e1003413. PMID: 33196656, PMCID: PMC7668585, DOI: 10.1371/journal.pmed.1003413.Peer-Reviewed Original ResearchMeSH KeywordsAdultBody Mass IndexCohort StudiesFemaleHumansMaleMendelian Randomization AnalysisMiddle AgedNorwayObesityProportional Hazards ModelsRisk FactorsSepsisConceptsBody mass indexHigher body mass indexBloodstream infectionsBSI incidenceBSI mortalityHazard ratioMass indexGeneral populationPopulation-based cohortAnalysis of patientsTerms of mortalityMendelian randomization studyTraditional epidemiological studiesMendelian randomization analysisObesity paradoxMean ageObservational studyEpidemiological studiesRandomization studyCausal associationSepsisMortalityPatientsInfectionRandomization analysisCardiometabolic Traits, Sepsis, and Severe COVID-19
Ponsford MJ, Gkatzionis A, Walker VM, Grant AJ, Wootton RE, Moore LSP, Fatumo S, Mason AM, Zuber V, Willer C, Rasheed H, Brumpton B, Hveem K, Damås J, Davies N, Åsvold BO, Solligård E, Jones S, Burgess S, Rogne T, Gill D. Cardiometabolic Traits, Sepsis, and Severe COVID-19. Circulation 2020, 142: 1791-1793. PMID: 32966752, PMCID: PMC7594537, DOI: 10.1161/circulationaha.120.050753.Peer-Reviewed Original ResearchBetacoronavirusBody Mass IndexCase-Control StudiesCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2DyslipidemiasGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHost-Pathogen InteractionsHumansMendelian Randomization AnalysisObesityPandemicsPhenotypePneumonia, ViralPolymorphism, Single NucleotideRisk FactorsSARS-CoV-2SepsisSeverity of Illness IndexSmoking