2024
Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.
Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt K, Ji J, Tong S, Tang S, Shi X. Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Environmental Health Perspectives 2024, 132: 97005. PMID: 39240788, PMCID: PMC11379127, DOI: 10.1289/ehp13864.Peer-Reviewed Original ResearchConceptsDyslipidemia markersCardiovascular diseaseMulti-omicsMarkers of dyslipidemiaExamination of cytokinesMeasurement of cytokinesSerum lipidomeSystemic inflammationMulti-omics profilingCardiac functionDyslipidemiaPrimary preventionClinical measuresSerumChinese adultsBlood transcriptomeImpact spectraCytokinesExposome-wide association studyInflammationMarkersBiomolecular pathwaysAssociationHealthy older adultsElectrocardiogramAssociation between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study
Sun P, Guo X, Ding E, Li C, Ren H, Xu Y, Qian J, Deng F, Shi W, Dong H, Lin E, Guo P, Fang J, Zhang Q, Zhao W, Tong S, Lu X, Pollitt K, Shi X, Tang S. Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study. Environmental Health Perspectives 2024, 132: 077005. PMID: 39028628, PMCID: PMC11259245, DOI: 10.1289/ehp13865.Peer-Reviewed Original ResearchConceptsFat mass indicatorsHealthy older adultsBayesian kernel machine regressionVisceral fat areaOlder adultsPercent body fatBody compositionBody fat massExposome-wide association studyPrevention of chronic diseasesAir pollution exposureBody composition indicatorsMediation analysisInBody 770 deviceHealthy adultsAssociated with increased body fat massBody composition changesKernel machine regressionBayesian kernel machine regression modelsChronic diseasesPollution exposureBody fatAssociation studiesAdverse health effectsFat area
2023
Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60–69 Years of Age: Evidence from the China BAPE Study
Ding E, Deng F, Fang J, Li T, Hou M, Liu J, Miao K, Yan W, Fang K, Shi W, Fu Y, Liu Y, Dong H, Dong L, Ding C, Liu X, Pollitt K, Ji J, Shi Y, Cai Y, Tang S, Shi X. Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60–69 Years of Age: Evidence from the China BAPE Study. Environmental Health Perspectives 2023, 131: 047009. PMID: 37042841, PMCID: PMC10094192, DOI: 10.1289/ehp11896.Peer-Reviewed Original ResearchConceptsYears of ageOPE exposureAdults 60OPE metabolitesCommon endocrine-disrupting chemicalsChina BAPE studySubsequent key eventsType 2 diabetesExposure reduction strategiesAdverse outcome pathwaysDiabetogenic effectInsulin resistanceUrine metabolomeElevated riskEster exposureParticipants 60Endocrine-disrupting chemicalsBlood transcriptomeAdverse effectsGlycometabolic disordersBiological etiologyAgeT2DMulti-omics analysisMarkers
2022
Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment
Jia X, Jin Q, Fang J, Shi Y, Hou M, Dong H, Liu Y, Deng F, Zhou Y, Pollitt K, Tang S, Shi X, Cai Y. Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment. Environmental Science And Technology 2022, 56: 7905-7916. PMID: 35584234, DOI: 10.1021/acs.est.2c00381.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlkanesulfonic AcidsAnimalsChinaDustEthersFluorocarbonsHumansMiddle AgedSulfonic AcidsConceptsElderly adultsHealthy elderly adultsBw/dayHuman exposureAdverse health effectsMedian intakeIntake assessmentElderly populationMonth assessment periodDietary ingestionHealth effectsInternal exposureWhole bloodPerfluorooctanoic acidExposure levelsImportant exposure pathwayExposure assessmentAssessment periodConsecutive monthsRegression analysisPolyfluoroalkyl substancesPerfluorooctanesulfonic acidCl-PFESAExposureAdults
2021
Solid fuels use for cooking and sleep health in adults aged 45 years and older in China
Yu H, Luo J, Chen K, Pollitt KJG, Liew Z. Solid fuels use for cooking and sleep health in adults aged 45 years and older in China. Scientific Reports 2021, 11: 13304. PMID: 34172775, PMCID: PMC8233310, DOI: 10.1038/s41598-021-92452-0.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutionChinaCoalCookingHealth SurveysHumansLongitudinal StudiesMiddle AgedRisk FactorsSleepConceptsSleep healthAverage sleep hoursShort sleep durationDays/weekPoor sleep healthCooking fuel typeOutdoor air pollutionSolid fuel useSleep durationSolid fuel usageSleep hoursChina HealthClean fuel useSolid cooking fuelsIntervention strategiesCHARLS 2011National surveyHealthInconsistent useAdultsConsistent useRetirement SurveyExposure impactLimited studiesDurationTelomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community
Katoto PDMC, Kayembe-Kitenge T, Pollitt KJG, Martens DS, Ghosh M, Nachega JB, Nemery B, Nawrot TS. Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community. Scientific Reports 2021, 11: 4031. PMID: 33597559, PMCID: PMC7889934, DOI: 10.1038/s41598-021-83281-2.Peer-Reviewed Original ResearchConceptsTreatment outcomesPTB patientsTelomere lengthActive pulmonary tuberculosis patientsMtDNA contentOutpatient TB clinicSuccessful TB treatmentProspective cohort studyPulmonary tuberculosis patientsTime of diagnosisOutcome of treatmentBlood mtDNA contentRural Democratic RepublicPeripheral blood leukocytesShorter telomere lengthLonger telomere lengthRelative telomere lengthHIV coinfectionTB clinicCohort studyPulmonary tuberculosisTB treatmentTuberculosis patientsPTB outcomesBlood leukocytes
2020
Exploring the external exposome using wearable passive samplers - The China BAPE study
Koelmel JP, Lin EZ, Guo P, Zhou J, He J, Chen A, Gao Y, Deng F, Dong H, Liu Y, Cha Y, Fang J, Beecher C, Shi X, Tang S, Godri Pollitt KJ. Exploring the external exposome using wearable passive samplers - The China BAPE study. Environmental Pollution 2020, 270: 116228. PMID: 33360595, DOI: 10.1016/j.envpol.2020.116228.Peer-Reviewed Original ResearchMeSH KeywordsAgedAir PollutantsChinaEnvironmental MonitoringExposomeHumansMiddle AgedWearable Electronic DevicesConceptsPassive samplersPersonal care productsPersonal exposure profilesAirborne contaminant exposurePassive air samplersChemicals of concernToxicity of chemicalsPolyaromatic hydrocarbonsCare productsChina BAPE studyElevated toxicityPersonal exposureChemicalsSources of exposureParticulate phaseInhalation routeExternal exposomeGreater health risksCigarette smokeContaminant exposureAntimicrobial soapHealthy participantsRouteAir samplerEnvironmental exposures
2018
Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study
Liu L, Urch B, Szyszkowicz M, Evans G, Speck M, Van Huang A, Leingartner K, Shutt RH, Pelletier G, Gold DR, Brook JR, Godri Pollitt K, Silverman FS. Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study. Environment International 2018, 121: 1331-1340. PMID: 30420132, PMCID: PMC6396878, DOI: 10.1016/j.envint.2018.10.055.Peer-Reviewed Original ResearchConceptsUbiquitin C-terminal hydrolase L1Vascular endothelium growth factorBiomarker levelsPost exposureSystemic inflammationOxidative stressNeural biomarkersS100 calcium-binding protein BCalcium-binding protein BNeural functionHealthy non-smoking volunteersConcentrated ambient PMAssessment of biomarkersNon-smoking volunteersStress marker cortisolAmbient PMUrinary malondialdehydeUrinary biomarkersUrinary cortisolInterleukin-6Mixed regression modelsVanillylmandelic acidInflammationMean concentrationGrowth factor
2016
Ambient PM2.5 and risk of emergency room visits for myocardial infarction: impact of regional PM2.5 oxidative potential: a case-crossover study
Weichenthal S, Lavigne E, Evans G, Pollitt K, Burnett RT. Ambient PM2.5 and risk of emergency room visits for myocardial infarction: impact of regional PM2.5 oxidative potential: a case-crossover study. Environmental Health 2016, 15: 46. PMID: 27012244, PMCID: PMC4806515, DOI: 10.1186/s12940-016-0129-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAir PollutantsChildChild, PreschoolColoradoCross-Over StudiesEmergency Service, HospitalEnvironmental ExposureEnvironmental MonitoringFiresHumansInfantInfant, NewbornMiddle AgedMyocardial InfarctionOdds RatioOxidation-ReductionParticulate MatterRespiratory Tract DiseasesRisk FactorsYoung Adult
2015
Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC)
Weichenthal S, Crouse DL, Pinault L, Godri-Pollitt K, Lavigne E, Evans G, van Donkelaar A, Martin RV, Burnett RT. Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC). Environmental Research 2015, 146: 92-99. PMID: 26745732, DOI: 10.1016/j.envres.2015.12.013.Peer-Reviewed Original ResearchConceptsCause-specific mortalityFine particulate air pollutionOxidative burdenParticulate air pollutionHazard ratioLung cancer hazard ratiosLong-term mortality riskCox proportional hazards modelCanadian Census HealthCancer hazard ratioLung cancer mortalityRisk of mortalityProportional hazards modelRespiratory tract lining fluidCanadian Long Form CensusEnvironment CohortSynthetic respiratory tract lining fluidCancer mortalityLung cancerLining fluidMortality riskHazards modelIndividual-level covariatesInterquartile changeLong-form census