2024
Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air–liquid interface
Upadhyay S, Rahman M, Rinaldi S, Koelmel J, Lin E, Mahesh P, Beckers J, Johanson G, Pollitt K, Palmberg L, Irmler M, Ganguly K. Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air–liquid interface. Respiratory Research 2024, 25: 49. PMID: 38245732, PMCID: PMC10799428, DOI: 10.1186/s12931-024-02686-5.Peer-Reviewed Original ResearchMeSH KeywordsBronchitis, ChronicCiliopathiesHumansLungMucous MembranePulmonary Disease, Chronic ObstructiveReactive Oxygen SpeciesSmokeWoodConceptsWood smokeBiomass fuel burningHuman primary bronchial epithelial cellsSecretion levels of proinflammatory cytokinesLevels of proinflammatory cytokinesPrimary bronchial epithelial cellsTumor necrosis factor-aAir-liquid interfacePrimary ciliary dyskinesiaHousehold air pollutionHighest increased riskBackgroundChronic obstructive pulmonary diseaseBronchial epithelial cellsChronic respiratory disordersPassive samplingToxicological end pointsAssociated with COPDExposed to WSObstructive pulmonary diseaseTobacco smoke exposureAir pollutionWS exposureExposure induced changesPulmonary toxicityAcute phase response
2021
Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada
Ripley S, Minet L, Zalzal J, Godri Pollitt K, Gao D, Lakey PSJ, Shiraiwa M, Maher BA, Hatzopoulou M, Weichenthal S. Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada. Environmental Science And Technology 2021, 56: 7256-7265. PMID: 34965092, DOI: 10.1021/acs.est.1c05364.Peer-Reviewed Original Research
2019
Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives
Hung S, Mohan A, Reckhow DA, Godri Pollitt KJ. Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives. Chemosphere 2019, 234: 902-908. PMID: 31519098, DOI: 10.1016/j.chemosphere.2019.06.086.Peer-Reviewed Original ResearchMeSH KeywordsBenzoquinonesDisinfectantsDisinfectionDrinking WaterHumansHydrolysisReactive Oxygen SpeciesWater Pollutants, ChemicalWater PurificationConceptsReactive oxygen speciesNormal human colon cellsHuman liver cancer cellsConcentration-dependent decreaseLiver cancer cellsIntracellular reactive oxygen speciesHuman colon cellsStudy designCell culture mediumCancer cellsColon cellsROS productionCulture mediumGreater cytotoxicityCell linesAcute cytotoxicityCell viabilityToxicological profileToxicological studiesCytotoxicityToxicityEnhanced toxicityOxygen speciesCell mediumPotential underestimation