2020
Toward Comprehensive Per- and Polyfluoroalkyl Substances Annotation Using FluoroMatch Software and Intelligent High-Resolution Tandem Mass Spectrometry Acquisition
Koelmel JP, Paige MK, Aristizabal-Henao JJ, Robey NM, Nason SL, Stelben PJ, Li Y, Kroeger NM, Napolitano MP, Savvaides T, Vasiliou V, Rostkowski P, Garrett TJ, Lin E, Deigl C, Jobst K, Townsend TG, Pollitt K, Bowden JA. Toward Comprehensive Per- and Polyfluoroalkyl Substances Annotation Using FluoroMatch Software and Intelligent High-Resolution Tandem Mass Spectrometry Acquisition. Analytical Chemistry 2020, 92: 11186-11194. PMID: 32806901, DOI: 10.1021/acs.analchem.0c01591.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsChromatography, LiquidHydrocarbons, FluorinatedSmall Molecule LibrariesSoftwareTandem Mass SpectrometryWater Pollutants, ChemicalConceptsNumber of annotationsSoftware librarySoftware applicationsFile conversionData analysis softwareData acquisition methodsFeature filteringTandem mass spectrometry acquisitionAnnotationSoftwareData setsWide coveragePeak pickingAnalysis softwareUsersThroughputExtensive data setFilteringPickingRelated fragmentsSetLibraryEnvironmentRulesMass spectrometry acquisition
2019
Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives
Hung S, Mohan A, Reckhow DA, Godri Pollitt KJ. Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives. Chemosphere 2019, 234: 902-908. PMID: 31519098, DOI: 10.1016/j.chemosphere.2019.06.086.Peer-Reviewed Original ResearchMeSH KeywordsBenzoquinonesDisinfectantsDisinfectionDrinking WaterHumansHydrolysisReactive Oxygen SpeciesWater Pollutants, ChemicalWater PurificationConceptsReactive oxygen speciesNormal human colon cellsHuman liver cancer cellsConcentration-dependent decreaseLiver cancer cellsIntracellular reactive oxygen speciesHuman colon cellsStudy designCell culture mediumCancer cellsColon cellsROS productionCulture mediumGreater cytotoxicityCell linesAcute cytotoxicityCell viabilityToxicological profileToxicological studiesCytotoxicityToxicityEnhanced toxicityOxygen speciesCell mediumPotential underestimation