2019
Chronic maternal cortisol excess during late gestation leads to metabolic alterations in the newborn heart
Walejko J, Antolic A, Koelmel J, Garrett T, Edison A, Keller-Wood M. Chronic maternal cortisol excess during late gestation leads to metabolic alterations in the newborn heart. AJP Endocrinology And Metabolism 2019, 316: e546-e556. PMID: 30620638, PMCID: PMC6459297, DOI: 10.1152/ajpendo.00386.2018.Peer-Reviewed Original ResearchConceptsNewborn heartLate gestationCortisol altersMaternal cortisolCardiac arrhythmiasFetal cardiac arrhythmiasMaternal serum specimensCortisol excessFetal exposureMaternal serumFetal metabolismCardiac metabolitesAbnormal elevationExcess cortisolLipid profileChronic increaseFetal serumGestation leadMetabolic alterationsSerum specimensHeart specimensFetal heartLipid metabolitesGlycerophospholipid metabolismCortisol
2018
Multiomics approach reveals metabolic changes in the heart at birth
Walejko J, Koelmel J, Garrett T, Edison A, Keller-Wood M. Multiomics approach reveals metabolic changes in the heart at birth. AJP Endocrinology And Metabolism 2018, 315: e1212-e1223. PMID: 30300011, PMCID: PMC6336953, DOI: 10.1152/ajpendo.00297.2018.Peer-Reviewed Original ResearchConceptsEnrichment analysisOverrepresentation enrichment analysisNewborn heartFetal heartTranscriptomic approachTranscriptomic levelT-testMetabolic changesFatty acidsMetabolomic levelsGlycerophospholipid metabolic pathwayTranscriptomic findingsMultiomics approachPropanoate metabolismTreatment of neonatesOxidative phosphorylationDifferential expressionDay of birthSingle-sample geneMetabolic pathwaysGreater abundanceStudent's t-testHeart failureRight ventricleIntraventricular septum