Multiomics approach reveals metabolic changes in the heart at birth
Walejko J, Koelmel J, Garrett T, Edison A, Keller-Wood M. Multiomics approach reveals metabolic changes in the heart at birth. AJP Endocrinology And Metabolism 2018, 315: e1212-e1223. PMID: 30300011, PMCID: PMC6336953, DOI: 10.1152/ajpendo.00297.2018.Peer-Reviewed Original ResearchConceptsEnrichment analysisOverrepresentation enrichment analysisNewborn heartFetal heartTranscriptomic approachTranscriptomic levelT-testMetabolic changesFatty acidsMetabolomic levelsGlycerophospholipid metabolic pathwayTranscriptomic findingsMultiomics approachPropanoate metabolismTreatment of neonatesOxidative phosphorylationDifferential expressionDay of birthSingle-sample geneMetabolic pathwaysGreater abundanceStudent's t-testHeart failureRight ventricleIntraventricular septum