Mass Spectrometric Methodologies for Investigating the Metabolic Signatures of Parkinson’s Disease: Current Progress and Future Perspectives
Gill E, Koelmel J, Yost R, Okun M, Vedam-Mai V, Garrett T. Mass Spectrometric Methodologies for Investigating the Metabolic Signatures of Parkinson’s Disease: Current Progress and Future Perspectives. Analytical Chemistry 2018, 90: 2979-2986. PMID: 29384654, DOI: 10.1021/acs.analchem.7b04084.Peer-Reviewed Original ResearchConceptsParkinson's diseaseMetabolic signaturesContext of PDDegeneration of motorProdromal Parkinson's diseaseDisease-modifying therapiesBasal ganglia circuitryMotor deficitsDopaminergic neuronsDopamine metabolitesSubstantia nigraDisease progressionDefinitive biomarkersEarly diagnosisUseful biomarkerNeurodegenerative disordersDiseaseNonmotor componentsField of MSBiomarkersPreanalytical factorsMetabolomics studiesCellular pathwaysFuture perspectivesEarly stages