2022
Diurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex
Tran T, Mach J, Gemikonakli G, Wu H, Allore H, Howlett SE, Little CB, Hilmer SN. Diurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex. Scientific Reports 2022, 12: 2168. PMID: 35140291, PMCID: PMC8828819, DOI: 10.1038/s41598-022-06039-4.Peer-Reviewed Original ResearchConceptsHigher Drug Burden IndexDrug Burden IndexBurden indexYoung miceOld micePhysical activityDifferent drug regimensWeeks of treatmentDrug-induced deliriumDaily physical activityTreatment × sex interactionBehavioral changesConsideration of ageSex-specific effectsSimvastatin monotherapyDrug regimensGait speedFunctional impairmentGlobal healthcare challengePolypharmacyQuality useOlder ageBehavioral declineMiceOlder adults
2002
Understanding the Treatment Preferences of Seriously Ill Patients
Fried TR, Bradley EH, Towle VR, Allore H. Understanding the Treatment Preferences of Seriously Ill Patients. New England Journal Of Medicine 2002, 346: 1061-1066. PMID: 11932474, DOI: 10.1056/nejmsa012528.Peer-Reviewed Original ResearchConceptsBurden of treatmentTreatment preferencesAdverse outcomesCognitive impairmentChronic obstructive pulmonary diseaseLow-burden treatmentCongestive heart failureObstructive pulmonary diseaseSevere functional impairmentLimited life expectancyOutcome of treatmentAdvance care planningYears of agePercent of participantsLife-sustaining treatmentHeart failureIll patientsPulmonary diseaseQuestions patientsPatient preferencesPrimary diagnosisPatients' attitudesFunctional impairmentHigh burdenCare planning