Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia
Tuey S, Atilano-Roque A, Charkoftaki G, Thurman J, Nolin T, Joy M. Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia. Xenobiotica 2021, 51: 657-667. PMID: 33870862, DOI: 10.1080/00498254.2021.1909783.Peer-Reviewed Original ResearchConceptsHuman kidney proximal tubule epithelial cellsUraemic serumProtein expressionHuman kidney proximal tubule cellsVitamin D treatmentEffect of cholecalciferolProximal tubule epithelial cellsKidney proximal tubule epithelial cellsKidney proximal tubule cellsDrug transport pathwaysProximal tubule cellsDrug disposition pathwaysEffect of treatmentTubule epithelial cellsMajor vitamin DVitD treatmentVitamin DFunctional assessmentTubule cellsNM dosesEthanol vehicleFunctional expressionCYP enzymesMRNA expressionDisposition pathways