Polymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment
Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2011, 727: 1-15. PMID: 21352951, DOI: 10.1016/j.mrrev.2011.02.001.Peer-Reviewed Original ResearchConceptsBase excision repairDNA repairGene expressionRepair functionUpstream regulatory sequencesDNA damaging agentsHomozygous variantToxicodynamic responseXRCC1 levelsRegulatory sequencesBinding sequenceExcision repairDamaging agentsProtein structureBER genesDNA damageAllele frequenciesCurrent databasePolymorphismGenotype effectsArg399Gln variantPhenotypeGenetic polymorphismsXRCC1Environmental agents