2020
Mortality under early access to antiretroviral therapy vs. Eswatini’s national standard of care: the MaxART clustered randomized stepped‐wedge trial
Chao A, Spiegelman D, Khan S, Walsh F, Mazibuko S, Pasipamire M, Chai B, Reis R, Mlambo K, Delva W, Khumalo G, Zwane M, Fleming Y, Mafara E, Hettema A, Lejeune C, Bärnighausen T, Okello V. Mortality under early access to antiretroviral therapy vs. Eswatini’s national standard of care: the MaxART clustered randomized stepped‐wedge trial. HIV Medicine 2020, 21: 429-440. PMID: 32458567, DOI: 10.1111/hiv.12876.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyMortality rateDisease-related mortality rateCox proportional hazards modelCause mortality ratesStepped-wedge trialProportional hazards modelStepped-wedge designQuality of lifeEvidence of harmClinic transitionSecondary outcomesSOC participantsHealth clinicsLong-term consequencesImplementation trialHazards modelHIVStudy participantsMortalityHealth systemDecrease infectionEarly accessClinicTherapyLong-term cancer survival in cohorts of U.S. health professionals.
Cheng E, Lee D, Tamimi R, Hankinson S, Willett W, Giovannucci E, Eliassen H, Tworoger S, Meir S, Mucci L, Fuchs C, Spiegelman D. Long-term cancer survival in cohorts of U.S. health professionals. Journal Of Clinical Oncology 2020, 38: 12075-12075. DOI: 10.1200/jco.2020.38.15_suppl.12075.Peer-Reviewed Original ResearchCancer-specific mortality ratesMortality rateCancer patientsOvarian cancerMajor cancersLong-term cancer survivalCorpus cancer patientsU.S. health professionalsHealth Professionals FollowUterine corpus cancerKaplan-Meier curvesMortality 10 yearsCause-specific mortality ratesCause of deathCumulative mortality rateLong-term survivalNHS IICorpus cancerIndex cancerProfessionals FollowUterine corpusColorectal cancerCancer survivalBreast cancerHealth StudyImpact of the Affordable Care Act on Colorectal Cancer Outcomes: A Systematic Review
Xu MR, Kelly AMB, Kushi LH, Reed ME, Koh HK, Spiegelman D. Impact of the Affordable Care Act on Colorectal Cancer Outcomes: A Systematic Review. American Journal Of Preventive Medicine 2020, 58: 596-603. PMID: 32008799, PMCID: PMC7175922, DOI: 10.1016/j.amepre.2019.11.018.Peer-Reviewed Original ResearchConceptsColorectal cancer screeningAffordable Care ActCancer screeningMedicaid expansionColorectal cancerCare ActNonsignificant increaseColorectal cancer morbidityColorectal cancer outcomesColorectal cancer incidenceStage of diagnosisAffordable Care Act's impactScreening ratesCancer outcomesCancer morbidityPrecancerous lesionsCancer incidenceNonsignificant decreaseEarly diagnosisMortality rateHealth outcomesSystematic reviewHealthcare accessRelevant studiesSignificant decrease
1997
Adverse Outcomes of Underuse of β-Blockers in Elderly Survivors of Acute Myocardial Infarction
Soumerai S, McLaughlin T, Spiegelman D, Hertzmark E, Thibault G, Goldman L. Adverse Outcomes of Underuse of β-Blockers in Elderly Survivors of Acute Myocardial Infarction. JAMA 1997, 277: 115-121. DOI: 10.1001/jama.1997.03540260029031.Peer-Reviewed Original ResearchCalcium channel blockersCalcium channel blocker useΒ-blockersAdverse outcomesChannel blockersBlocker useEligible patientsMyocardial infarctionRelative riskMortality rateAcute myocardial infarction survivorsBaseline risk variablesCardiac hospital readmissionsElderly AMI survivorsΒ-blocker therapyΒ-blocker usePredictors of survivalRisk of deathRetrospective cohort designAcute myocardial infarctionDemonstrable adverse effectsMyocardial infarction survivorsNew β-blockerPrescription drug coverageMeasurable adverse outcomesAdverse outcomes of underuse of beta-blockers in elderly survivors of acute myocardial infarction.
Soumerai SB, McLaughlin TJ, Spiegelman D, Hertzmark E, Thibault G, Goldman L. Adverse outcomes of underuse of beta-blockers in elderly survivors of acute myocardial infarction. JAMA 1997, 277: 115-21. PMID: 8990335, DOI: 10.1001/jama.277.2.115.Peer-Reviewed Original ResearchConceptsCalcium channel blockersCalcium channel blocker useAdverse outcomesChannel blockersBlocker useEligible patientsMyocardial infarctionRelative riskMortality rateAcute myocardial infarction survivorsBaseline risk variablesCardiac hospital readmissionsElderly AMI survivorsBeta-blocker therapyBeta-blocker usePredictors of survivalRisk of deathRetrospective cohort designAcute myocardial infarctionDemonstrable adverse effectsMyocardial infarction survivorsPrescription drug coverageMeasurable adverse outcomesBeta blockersElderly patients