2014
Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers
Singh S, Arcaroli J, Thompson DC, Messersmith W, Vasiliou V. Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers. Advances In Experimental Medicine And Biology 2014, 815: 281-294. PMID: 25427913, PMCID: PMC4347404, DOI: 10.1007/978-3-319-09614-8_16.Peer-Reviewed Original ResearchConceptsPancreatic cancerColorectal cancerRetinoic acidChronic alcohol consumptionImportant risk factorCancer-related deathCancer stem cellsProgression of cancerPoor prognosisEventual prognosisRisk factorsAlcohol consumptionCancerImportant mechanistic roleTumor developmentRetinaldehyde dehydrogenasesCancer initiationPrognosisColonTumorsStem cellsProgressionBiomarkersALDH1A1Mechanistic role
2012
Ocular aldehyde dehydrogenases: Protection against ultraviolet damage and maintenance of transparency for vision
Chen Y, Thompson DC, Koppaka V, Jester JV, Vasiliou V. Ocular aldehyde dehydrogenases: Protection against ultraviolet damage and maintenance of transparency for vision. Progress In Retinal And Eye Research 2012, 33: 28-39. PMID: 23098688, PMCID: PMC3570594, DOI: 10.1016/j.preteyeres.2012.10.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAldehyde dehydrogenasePutative regulatory functionTaxon-specific mannerNon-catalytic functionsRetinoic acid signalingALDH proteinsMaintenance of transparencyCellular transparencyAcid signalingCorneal crystallinsExogenous aldehydesEye developmentOxygen-induced damageCorneal cell proliferationStructural roleRegulatory functionsException of rabbitsMost mammalsRetinaldehyde dehydrogenasesLens crystallinsALDH1A1 proteinMammalian corneaAnimal speciesCell proliferationDependent oxidation