2023
Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study
Ni W, Breitner S, Nikolaou N, Wolf K, Zhang S, Peters A, Herder C, Schneider A. Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study. Environmental Science And Technology 2023, 57: 12210-12221. PMID: 37552838, PMCID: PMC10448716, DOI: 10.1021/acs.est.3c00302.Peer-Reviewed Original ResearchConceptsKORA F4 studyBiomarkers of subclinical inflammationHigher risk of chronic diseasesF4 studyLevels of air pollutionLow air temperatureRisk of chronic diseasesPopulation-based KORA F4 studyCross-sectional analysisSubclinical inflammationAdverse health effectsCumulative lagAssociated with higher levelsAir pollutionAir temperatureChronic diseasesNeurotrophin-3Older participantsInterleukin-6Additive modelMedium-term effectsProximity extension assay technologyHealth effectsCardiovascular diseaseHigh riskAssociations between medium- and long-term exposure to air temperature and epigenetic age acceleration
Ni W, Nikolaou N, Ward-Caviness C, Breitner S, Wolf K, Zhang S, Wilson R, Waldenberger M, Peters A, Schneider A. Associations between medium- and long-term exposure to air temperature and epigenetic age acceleration. Environment International 2023, 178: 108109. PMID: 37517177, PMCID: PMC10656697, DOI: 10.1016/j.envint.2023.108109.Peer-Reviewed Original ResearchMeSH KeywordsAgingAir PollutionDNA MethylationEpigenesis, GeneticHumansInfantParticulate MatterTemperatureConceptsEpigenetic age accelerationGeneralized estimating equationsExposure to high air temperaturesAge accelerationAverage air temperatureDistributed lag non-linear modelMeasures of epigenetic age accelerationAir temperatureHuman health worldwideExposure to air temperaturesSpatial variationClimate changeEffects of air temperatureAnnual average temperatureKORA F4PhenoAge accelerationHigh air temperatureGrimAge accelerationHannumAAGrimAAEstimating equationsAging populationHorvathAATemporal variation in the association between temperature and cause-specific mortality in 15 German cities
Rai M, Breitner S, Huber V, Zhang S, Peters A, Schneider A. Temporal variation in the association between temperature and cause-specific mortality in 15 German cities. Environmental Research 2023, 229: 115668. PMID: 36958378, DOI: 10.1016/j.envres.2023.115668.Peer-Reviewed Original ResearchConceptsCVD mortalityNon-accidentalRelative riskMortality riskAge- and sex-stratified analysesMultivariate meta-analytic modelsCause-specific mortalitySex-stratified analysesAge groupsTemperature-mortality associationsRD mortalityYounger age groupsOlder age groupsMeta-analytic modelCold-relatedStudy periodRD deathsMortalityAssociationRiskTemperature percentileHeat-related risksCVDGerman citiesTime series analysis
2022
Higher Daily Air Temperature Is Associated with Shorter Leukocyte Telomere Length: KORA F3 and KORA F4
Ni W, Wolf K, Breitner S, Zhang S, Nikolaou N, Ward-Caviness C, Waldenberger M, Gieger C, Peters A, Schneider A. Higher Daily Air Temperature Is Associated with Shorter Leukocyte Telomere Length: KORA F3 and KORA F4. Environmental Science And Technology 2022, 56: 17815-17824. PMID: 36442845, PMCID: PMC9775210, DOI: 10.1021/acs.est.2c04486.Peer-Reviewed Original ResearchConceptsLeukocyte telomere lengthAssociated with shorter leukocyte telomere lengthShorter leukocyte telomere lengthKORA F3Cohort studyParticipant's residential addressMeta-analysisShort-term effectsPopulation-based studyPopulation-based settingInterquartile rangeShort-term associationsResidential addressesKORA F4Telomere lengthAge-related morbidityAdult populationPCR-based methodsEffects of air temperatureKORADaily air temperatureQuantitative PCR-based methodCohortParticipantsGeneralized additive model
2021
A systematic review on the association between total and cardiopulmonary mortality/morbidity or cardiovascular risk factors with long-term exposure to increased or decreased ambient temperature
Zafeiratou S, Samoli E, Dimakopoulou K, Rodopoulou S, Analitis A, Gasparrini A, Stafoggia M, De' Donato F, Rao S, Monteiro A, Rai M, Zhang S, Breitner S, Aunan K, Schneider A, Katsouyanni K, team E. A systematic review on the association between total and cardiopulmonary mortality/morbidity or cardiovascular risk factors with long-term exposure to increased or decreased ambient temperature. The Science Of The Total Environment 2021, 772: 145383. PMID: 33578152, DOI: 10.1016/j.scitotenv.2021.145383.Peer-Reviewed Original ResearchConceptsHealth outcomesRisk of biasCardiovascular risk factorsSystematic reviewCrude exposure assessmentShort-term mortality displacementDiverse health outcomesAssociation of long-termRisk factorsHigher obesityEffect modificationInadequate adjustmentCardiopulmonary mortalityWorld Health OrganizationEffect modifiersOutcome prevalenceMortality displacementAnnual temperature indicesLong-term exposureAir pollutionCardiovascular mortalityHealthHealth OrganizationHealth effectsRespiratory outcomes