2023
Residential proximity to unconventional oil and gas development and birth defects in Ohio
Gaughan C, Sorrentino K, Liew Z, Johnson N, Clark C, Soriano M, Plano J, Plata D, Saiers J, Deziel N. Residential proximity to unconventional oil and gas development and birth defects in Ohio. Environmental Research 2023, 229: 115937. PMID: 37076028, PMCID: PMC10198955, DOI: 10.1016/j.envres.2023.115937.Peer-Reviewed Original ResearchConceptsNeural tube defectsCertain birth defectsBirth defectsOdds ratioRegistry-based cohort studyTube defectsConfidence intervalsResidential proximityState birth recordsBirth defect typeState surveillance systemsMaternal residential proximityLimb reduction defectsCohort studyUnexposed mothersStructural birth defectsLive birthsInfant sexBirth recordsSpina bifidaReduction defectsFemale offspringDevelopmental toxicantsExposure metrics
2022
Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017
Clark CJ, Johnson NP, Soriano M, Warren JL, Sorrentino KM, Kadan-Lottick NS, Saiers JE, Ma X, Deziel NC. Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017. Environmental Health Perspectives 2022, 130: 087001. PMID: 35975995, PMCID: PMC9383266, DOI: 10.1289/ehp11092.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCase-control studyOdds ratioChildhood leukemiaLymphoblastic leukemiaPerinatal windowRegistry-based case-control studyChildhood acute lymphoblastic leukemiaConfidence intervalsResidential proximityChildren ages 2Risk factorsMaternal raceChild healthExposure windowsSocio-economic statusPotential associationLeukemiaLogistic regressionAge 2Birth yearCommon formBirth residenceDevelopment exposureOddsPrenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort
Luo J, Ramlau-Hansen CH, Kesmodel US, Xiao J, Vasiliou V, Deziel NC, Zhang Y, Olsen J, Liew Z. Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort. Environmental Health Perspectives 2022, 130: 017006. PMID: 35080464, PMCID: PMC8791068, DOI: 10.1289/ehp9478.Peer-Reviewed Original ResearchConceptsDanish National Birth CohortMaternal alcohol intakePrenatal PFAS exposurePalpebral fissure lengthShorter palpebral fissure lengthNational Birth CohortYears of agePFAS exposureSecond tertileAlcohol intakePrenatal exposureOdds ratioBirth cohortSpecific neurologic deficitsConfidence intervalsFetal brain developmentSex-specific associationsNeurologic deficitsFirst trimesterPotential confoundersNeurodevelopmental effectsAlcohol exposureStratified analysisNormal groupMultinomial logistic regression
2020
Exposure to polychlorinated biphenyls and organochlorine pesticides and thyroid cancer in connecticut women
Deziel NC, Warren JL, Huang H, Zhou H, Sjodin A, Zhang Y. Exposure to polychlorinated biphenyls and organochlorine pesticides and thyroid cancer in connecticut women. Environmental Research 2020, 192: 110333. PMID: 33068584, PMCID: PMC7736223, DOI: 10.1016/j.envres.2020.110333.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerThyroid cancerPCBs/OCPsOdds ratioSubsequent thyroid cancer riskMulti-pollutant modelingSerum Polychlorinated BiphenylsBody mass indexConfidence intervalsThyroid cancer riskThyroid cancer incidenceEarly life exposureEnvironmental risk factorsSingle-pollutant modelsLogistic regression modelsIsotope dilution high-resolution mass spectrometryMass indexTumor sizeCancer incidenceRisk factorsConnecticut womenFamily historyMulti-pollutant analysisCancer riskThyroid hormone disruptorsBirth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California
Deziel N, Zhang Y, Wang R, Wiemels JL, Morimoto L, Clark CJ, Metayer C, Ma X. Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California. Thyroid 2020, 31: 596-606. PMID: 32912083, PMCID: PMC8195873, DOI: 10.1089/thy.2020.0217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetBirth CertificatesBirth OrderBirth WeightCaliforniaCase-Control StudiesChildChild, PreschoolEducational StatusFemaleHispanic or LatinoHumansIncidenceInfantInfant, NewbornMaleRace FactorsRegistriesRisk AssessmentRisk FactorsSex FactorsThyroid NeoplasmsTime FactorsYoung AdultConceptsPediatric thyroid cancerHigh birth weightFollicular thyroid cancerThyroid cancerHigher birth orderBirth characteristicsRisk factorsHispanic ethnicityBirth weightOdds ratioFirst primary thyroid cancerPapillary thyroid cancer casesBirth orderMultivariable logistic regression modelSecond primary malignanciesLong-term therapyAdjusted odds ratioPopulation-based studyPrimary thyroid cancerRecord linkage studyConfidence intervalsImportant risk factorCancer registry dataCase-control studyThyroid cancer casesDioxin exposure and breast cancer risk in a prospective cohort study
VoPham T, Bertrand KA, Jones RR, Deziel NC, DuPré NC, James P, Liu Y, Vieira VM, Tamimi RM, Hart JE, Ward MH, Laden F. Dioxin exposure and breast cancer risk in a prospective cohort study. Environmental Research 2020, 186: 109516. PMID: 32305677, PMCID: PMC7363533, DOI: 10.1016/j.envres.2020.109516.Peer-Reviewed Original ResearchConceptsNurses' Health Study IIBreast cancer riskInvasive breast cancer riskHealth Study IICancer riskDioxin exposureHazard ratioBreast cancer risk factorsInvasive breast cancer casesInvasive breast cancer diagnosisER- breast cancerMedical record reviewProspective cohort studyCancer risk factorsConfidence intervalsBreast cancer casesResidential proximityGeocoded residential addressesPositive associationBreast cancer diagnosisBiennial questionnairesCohort studyMenopausal statusRecord reviewRisk factorsAssessing Endogenous and Exogenous Hormone Exposures and Breast Development in a Migrant Study of Bangladeshi and British Girls
Howland RE, Deziel NC, Bentley GR, Booth M, Choudhury OA, Hofmann JN, Hoover RN, Katki HA, Trabert B, Fox SD, Troisi R, Houghton LC. Assessing Endogenous and Exogenous Hormone Exposures and Breast Development in a Migrant Study of Bangladeshi and British Girls. International Journal Of Environmental Research And Public Health 2020, 17: 1185. PMID: 32069802, PMCID: PMC7068451, DOI: 10.3390/ijerph17041185.Peer-Reviewed Original ResearchConceptsEstrogen metabolitesBPA-glucuronideBreast developmentMigrant studiesBreast cancer incidenceEndogenous estrogen levelsBisphenol A (BPA) exposureExogenous hormone exposureCross-sectional studyBangladeshi girlsTime of interviewUrine spot samplesHazard ratioEstrogen levelsA ExposureCancer incidenceEarlier thelarcheTanner stageUbiquitous exposureHormone exposureThelarcheLiquid chromatography-tandem mass spectrometryConfidence intervalsWhite BritishAdolescent girls
2019
Exposure to Polybrominated Diphenyl Ethers and a Polybrominated Biphenyl and Risk of Thyroid Cancer in Women: Single and Multi-Pollutant Approaches
Deziel NC, Alfonso-Garrido J, Warren JL, Huang H, Sjodin A, Zhang Y. Exposure to Polybrominated Diphenyl Ethers and a Polybrominated Biphenyl and Risk of Thyroid Cancer in Women: Single and Multi-Pollutant Approaches. Cancer Epidemiology Biomarkers & Prevention 2019, 28: 1755-1764. PMID: 31387967, PMCID: PMC6774868, DOI: 10.1158/1055-9965.epi-19-0526.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerThyroid cancerPTC riskLipid-adjusted serum concentrationsPapillary thyroid cancer casesMulti-pollutant approachSerum samplesMulti-pollutant modelingThyroid cancer incidenceInterquartile range increaseThyroid cancer casesMulti-pollutant modelsSingle-pollutant modelsLogistic regression modelsPBB exposureDecreased riskProspective studySerum concentrationsCancer incidenceCancer casesAlcohol consumptionFemale controlsLow categoryConfidence intervalsPBB mixture
2018
Cell phone use and risk of thyroid cancer: a population-based case–control study in Connecticut
Luo J, Deziel NC, Huang H, Chen Y, Ni X, Ma S, Udelsman R, Zhang Y. Cell phone use and risk of thyroid cancer: a population-based case–control study in Connecticut. Annals Of Epidemiology 2018, 29: 39-45. PMID: 30446214, PMCID: PMC6344271, DOI: 10.1016/j.annepidem.2018.10.004.Peer-Reviewed Original ResearchConceptsPopulation-based case-control studyCase-control studyThyroid cancerThyroid microcarcinomaOdds ratioUnconditional logistic regressionPopulation-based controlsThyroid cancer casesWarrants further investigationCancer casesSuggestive increaseElevated riskCell phone useSignificant associationCancerLogistic regressionMicrocarcinomaMore frequent usersConfidence intervalsRiskFrequent usersPhone useFurther investigationAssociationHoursShale gas activity and increased rates of sexually transmitted infections in Ohio, 2000–2016
Deziel NC, Humeau Z, Elliott EG, Warren JL, Niccolai LM. Shale gas activity and increased rates of sexually transmitted infections in Ohio, 2000–2016. PLOS ONE 2018, 13: e0194203. PMID: 29570712, PMCID: PMC5865738, DOI: 10.1371/journal.pone.0194203.Peer-Reviewed Original ResearchConceptsMixed-effects Poisson regression modelsAnnual rate ratiosCases of chlamydiaRate ratioRates of chlamydiaRates of gonorrheaCommunity health effortsPoisson regression modelsPotential confoundersSTI ratesHealth effortsGonorrheaReportable STIsChlamydiaEcologic studySyphilisConfidence intervalsOhio DepartmentInfectionSecular trends
2015
Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma
DellaValle CT, Deziel NC, Jones RR, Colt JS, De Roos AJ, Cerhan JR, Cozen W, Severson RK, Flory AR, Morton LM, Ward MH. Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma. Cancer Causes & Control 2015, 27: 1-13. PMID: 26573845, PMCID: PMC5358542, DOI: 10.1007/s10552-015-0660-y.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaT-cell lymphomaOdds ratioCell lymphomaRisk of NHLNational Cancer Institute's Surveillance EpidemiologyMulticenter case-control studyB-cell lymphoma subtypesUnconditional logistic regressionCase-control studyConfidence intervalsHighest tertileLowest tertileHistologic typeSurveillance EpidemiologyNHL overallLymphoma subtypesWhite raceElevated riskSecondary aimConclusionOur resultsLymphomaOlder ageTertileLogistic regression
2014
Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia
Deziel NC, Rull RP, Colt JS, Reynolds P, Whitehead TP, Gunier RB, Month SR, Taggart DR, Buffler P, Ward MH, Metayer C. Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia. Environmental Research 2014, 133: 388-395. PMID: 24948546, PMCID: PMC4119528, DOI: 10.1016/j.envres.2014.04.033.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaLymphoblastic leukemiaOdds ratioPopulation-based case-control studyDiagnosis/reference datePAH exposureRisk of childhoodConfidence intervalsCase-control studyResidential dustVacuum dustLog-transformed concentrationsLogistic regressionProbable human carcinogenHigh volume small surface samplerDemographic characteristics