2017
Closely-related Borrelia burgdorferi (sensu stricto) strains exhibit similar fitness in single infections and asymmetric competition in multiple infections
Rynkiewicz EC, Brown J, Tufts DM, Huang CI, Kampen H, Bent SJ, Fish D, Diuk-Wasser MA. Closely-related Borrelia burgdorferi (sensu stricto) strains exhibit similar fitness in single infections and asymmetric competition in multiple infections. Parasites & Vectors 2017, 10: 64. PMID: 28166814, PMCID: PMC5292797, DOI: 10.1186/s13071-016-1964-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibiosisArachnid VectorsBorrelia burgdorferiDisease Transmission, InfectiousGenetic FitnessIxodesMicePeromyscusConceptsAsymmetric competitive interactionsPatterns of coexistenceBiotic contextCommon disease vectorPathogen communitiesVector-borne pathogensBorrelia burgdorferiLong-term persistencePathogen speciesAsymmetric competitionPathogen dynamicsInfection phenotypesSimilar fitnessTransmission phenotypeDisease vectorsTemperate regionsCompetitive interactionsTransmission advantagePathogen strainsPathogen persistenceBlack-legged tickCompetitive strainsPeromyscus leucopusWhite-footed miceHost
2014
Blood transfusion transmission of the tick‐borne relapsing fever spirochete Borrelia miyamotoi in mice
Krause PJ, Hendrickson JE, Steeves TK, Fish D. Blood transfusion transmission of the tick‐borne relapsing fever spirochete Borrelia miyamotoi in mice. Transfusion 2014, 55: 593-597. PMID: 25251880, DOI: 10.1111/trf.12879.Peer-Reviewed Original ResearchConceptsTransfusion transmissionRed blood cellsBorrelia miyamotoiBlood transfusion transmissionMurine transfusion modelFever spirochete Borrelia miyamotoiSpirochete clearanceRecipient bloodC57BL/6 miceMouse recipientsTransfusion modelMouse modelTransfusionMurine bloodHuman infectionsWet mountLyme diseaseStudy designBlood cellsMiceMiyamotoiSpirochetemiaFever spirochetesBloodBodied ticksMonitoring Human Babesiosis Emergence through Vector Surveillance New England, USA - Volume 20, Number 2—February 2014 - Emerging Infectious Diseases journal - CDC
Diuk-Wasser MA, Liu Y, Steeves TK, Folsom-O'Keefe C, Dardick KR, Lepore T, Bent SJ, Usmani-Brown S, Telford SR, Fish D, Krause PJ. Monitoring Human Babesiosis Emergence through Vector Surveillance New England, USA - Volume 20, Number 2—February 2014 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2014, 20: 225-231. PMID: 24447577, PMCID: PMC3901474, DOI: 10.3201/eid2002.130644.Peer-Reviewed Original ResearchConceptsHuman babesiosisInfectious Diseases journal - CDCProtozoan Babesia microtiDisease-endemic areasTick-borne diseaseBabesiosis-endemic areasSame tick vectorInfection rateInfection ratioTick infection ratesLyme diseaseBabesia microtiHuman casesDiseaseDisease expansionBabesiosisReservoir hostsTick vectorHuman diseasesSurveillanceClose associationGut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete
Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, DePonte K, Fish D, Fikrig E. Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete. Cell Host & Microbe 2014, 15: 58-71. PMID: 24439898, PMCID: PMC3905459, DOI: 10.1016/j.chom.2013.12.001.Peer-Reviewed Original ResearchConceptsPeritrophic matrixTranscription factor signal transducerPathogen colonizationLyme disease spirochete Borrelia burgdorferiActivator of transcriptionGut microbiotaArthropod gutsSignal transducerLyme disease spirocheteFunctional linkArthropod vectorsMajor vectorKey glycoproteinsHuman pathogensSpirochete Borrelia burgdorferiGut epitheliumIxodes scapularis ticksColonizationGut epithelial barrierMicrobiotaExpressionGut lumenScapularis ticksBorrelia burgdorferiEpithelial barrier
2013
Quantitative PCR for Detection of Babesia microti in Ixodes scapularis Ticks and in Human Blood
Rollend L, Bent SJ, Krause PJ, Usmani-Brown S, Steeves TK, States SL, Lepore T, Ryan R, Dias F, Mamoun C, Fish D, Diuk-Wasser MA. Quantitative PCR for Detection of Babesia microti in Ixodes scapularis Ticks and in Human Blood. Vector-Borne And Zoonotic Diseases 2013, 13: 784-790. PMID: 24107203, PMCID: PMC3822370, DOI: 10.1089/vbz.2011.0935.Peer-Reviewed Original ResearchConceptsB. microti DNAIxodes scapularis ticksHuman babesiosisScapularis ticksBabesia microtiQuantitative PCRViral-like illnessB. microti infectionAcute infectionBlood transfusionDisparate incidenceMicroti infectionProlonged illnessBlood supplyI. scapularis ticksBlood samplesEpidemiological surveillanceInfected peopleBorrelia miyamotoiB. microtiBorrelia burgdorferiHuman blood samplesI. scapularis nymphsAnaplasma phagocytophilumSpecific quantitative PCR
2012
Geographic Variation in the Relationship between Human Lyme Disease Incidence and Density of Infected Host-Seeking Ixodes scapularis Nymphs in the Eastern United States
Pepin KM, Eisen RJ, Mead PS, Piesman J, Fish D, Hoen AG, Barbour AG, Hamer S, Diuk-Wasser MA. Geographic Variation in the Relationship between Human Lyme Disease Incidence and Density of Infected Host-Seeking Ixodes scapularis Nymphs in the Eastern United States. American Journal Of Tropical Medicine And Hygiene 2012, 86: 1062-1071. PMID: 22665620, PMCID: PMC3366524, DOI: 10.4269/ajtmh.2012.11-0630.Peer-Reviewed Original ResearchPredicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease
Tsao K, Fish D, Galvani AP. Predicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease. Vector-Borne And Zoonotic Diseases 2012, 12: 544-551. PMID: 22251312, DOI: 10.1089/vbz.2011.0731.Peer-Reviewed Original ResearchConceptsMice vaccinationTick biteB. burgdorferi transmissionLyme disease preventionTick blood mealVaccination outcomesHuman riskVaccination effortsDisease preventionLyme diseaseVaccinationInfection prevalenceBorrelia burgdorferiMiceWildlife vaccinationB. burgdorferiCausative agentPredicted outcomeBlood mealVector ticksBiteOutcomesBurgdorferiRiskWildlife reservoirs
2011
Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato
Margos G, Vollmer S, Ogden N, Fish D. Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato. Infection Genetics And Evolution 2011, 11: 1545-1563. PMID: 21843658, PMCID: PMC3214628, DOI: 10.1016/j.meegid.2011.07.022.Peer-Reviewed Original ResearchConceptsEvolutionary relationshipsSingle-locus approachesMultilocus sequence typing (MLST) schemeSequence typing schemePopulation geneticsPopulation structureBacterial speciesSensu latoLyme borreliosis spirochetesNovel insightsPhylogenyImportant groupLocus approachZoonotic bacteriaBacterial microorganismsBorrelia burgdorferi sensu latoTaxonomyTyping schemeBurgdorferi sensu latoGeneticsSpeciesLatoMicroorganismsBacteriaEvolution
2010
Multilocus sequence analysis of Borrelia bissettii strains from North America reveals a new Borrelia species, Borrelia kurtenbachii
Margos G, Hojgaard A, Lane R, Cornet M, Fingerle V, Rudenko N, Ogden N, Aanensen D, Fish D, Piesman J. Multilocus sequence analysis of Borrelia bissettii strains from North America reveals a new Borrelia species, Borrelia kurtenbachii. Ticks And Tick-borne Diseases 2010, 1: 151-158. PMID: 21157575, PMCID: PMC3000690, DOI: 10.1016/j.ttbdis.2010.09.002.Peer-Reviewed Original ResearchConceptsMultilocus sequence analysisSequence analysisGenetic distance analysisNew Borrelia speciesBorrelia speciesDifferent transmission cyclesBorrelia bissettiiB. bissettiiLinear chromosomesPhylogenetic relationshipsEcological differencesConcatenated sequencesPhylogenetic analysisHousekeeping genesVector associationNorth AmericaInternal fragmentDistance analysisBorrelia genospeciesB. carolinensisReservoir hostsTransmission cycleI. spinipalpisIxodes pacificusRelated clusters
2009
Niche Partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the Same Tick Vector and Mammalian Reservoir Species
Barbour A, Bunikis J, Travinsky B, Hoen A, Diuk-Wasser M, Fish D, Tsao J. Niche Partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the Same Tick Vector and Mammalian Reservoir Species. American Journal Of Tropical Medicine And Hygiene 2009, 81: 1120-1131. PMID: 19996447, PMCID: PMC2841027, DOI: 10.4269/ajtmh.2009.09-0208.Peer-Reviewed Original ResearchCommunity-Based Prevention of Lyme Disease and Other Tick-Borne Diseases Through Topical Application of Acaricide to White-Tailed Deer: Background and Rationale
Fish D, Childs JE. Community-Based Prevention of Lyme Disease and Other Tick-Borne Diseases Through Topical Application of Acaricide to White-Tailed Deer: Background and Rationale. Vector-Borne And Zoonotic Diseases 2009, 9: 357-364. PMID: 19650729, DOI: 10.1089/vbz.2009.0022.Peer-Reviewed Original ResearchEvaluation of the United States Department of Agriculture Northeast Area-Wide Tick Control Project by Meta-Analysis
Brei B, Brownstein J, George J, Pound J, Miller J, Daniels T, Falco R, Stafford K, Schulze T, Mather T, Carroll J, Fish D. Evaluation of the United States Department of Agriculture Northeast Area-Wide Tick Control Project by Meta-Analysis. Vector-Borne And Zoonotic Diseases 2009, 9: 423-430. PMID: 19650737, PMCID: PMC2904192, DOI: 10.1089/vbz.2008.0150.Peer-Reviewed Original ResearchEffects of Tick Control by Acaricide Self-Treatment of White-Tailed Deer on Host-Seeking Tick Infection Prevalence and Entomologic Risk for Ixodes scapularis-Borne Pathogens
Hoen A, Rollend L, Papero M, Carroll J, Daniels T, Mather T, Schulze T, Stafford K, Fish D. Effects of Tick Control by Acaricide Self-Treatment of White-Tailed Deer on Host-Seeking Tick Infection Prevalence and Entomologic Risk for Ixodes scapularis-Borne Pathogens. Vector-Borne And Zoonotic Diseases 2009, 9: 431-438. PMID: 19650738, DOI: 10.1089/vbz.2008.0155.Peer-Reviewed Original ResearchConceptsEntomologic riskInfection prevalenceB. burgdorferiPrevalence of infectionFever group spirochetesBacterial coinfectionSelf treatmentTick infection prevalenceLyme diseaseBorrelia miyamotoiB. miyamotoiBacterial agentsPrevalenceBorrelia burgdorferiAnaplasma phagocytophilumA. phagocytophilumAdultsRiskBurgdorferiInfectionDiseaseHost-seeking ticksProportion of ticksAdult ticksTick controlThe United States Department of Agriculture Northeast Area-Wide Tick Control Project: History and Protocol
Pound J, Miller J, George J, Fish D. The United States Department of Agriculture Northeast Area-Wide Tick Control Project: History and Protocol. Vector-Borne And Zoonotic Diseases 2009, 9: 365-370. PMID: 19650730, DOI: 10.1089/vbz.2008.0182.Peer-Reviewed Original ResearchAcaricidal Treatment of White-Tailed Deer to Control Ixodes scapularis (Acari: Ixodidae) in a New York Lyme Disease-Endemic Community
Daniels T, Falco R, Mchugh E, Vellozzi J, Boccia T, Denicola A, Pound J, Miller J, George J, Fish D. Acaricidal Treatment of White-Tailed Deer to Control Ixodes scapularis (Acari: Ixodidae) in a New York Lyme Disease-Endemic Community. Vector-Borne And Zoonotic Diseases 2009, 9: 381-387. PMID: 19650732, DOI: 10.1089/vbz.2008.0197.Peer-Reviewed Original Research
2006
Fundamental processes in the evolutionary ecology of Lyme borreliosis
Kurtenbach K, Hanincová K, Tsao J, Margos G, Fish D, Ogden N. Fundamental processes in the evolutionary ecology of Lyme borreliosis. Nature Reviews Microbiology 2006, 4: 660-669. PMID: 16894341, DOI: 10.1038/nrmicro1475.Peer-Reviewed Original ResearchConceptsEvolutionary ecologyGenetic changesMultiple-niche polymorphismVector-borne zoonosesB. burgdorferi s.Natural transmission cycleEvolutionary relationshipsEcological parallelsEvolutionary biologyVector-borne pathogensBurgdorferi s.Population fluctuationsProcess-based modelEcologySensu latoDifferent membersFundamental processesVector-borne diseasesPathogensTransmission cycleSpeciesBorrelia burgdorferi sensu latoSame fundamental questionsKey processesBurgdorferi sensu latoMyD88 Deficiency Enhances Acquisition and Transmission of Borrelia burgdorferi by Ixodes scapularis Ticks
Bockenstedt LK, Liu N, Schwartz I, Fish D. MyD88 Deficiency Enhances Acquisition and Transmission of Borrelia burgdorferi by Ixodes scapularis Ticks. Infection And Immunity 2006, 74: 2154-2160. PMID: 16552045, PMCID: PMC1418887, DOI: 10.1128/iai.74.4.2154-2160.2006.Peer-Reviewed Original ResearchConceptsMyD88-/- miceToll-like receptorsWT miceB. burgdorferiB. burgdorferi strainsInnate immune cellsBurgdorferi strainsSkin inoculation siteB. burgdorferi DNAHigh virulence strainDegree of infectivityIxodes scapularis ticksMyD88 deficiencyMolecule MyD88Immune cellsMore spirochetesTransmission of BorreliaEffector functionsHost immunityBorrelia burgdorferi strainsClinical isolatesPathogen burdenMiceBlood meal hostsScapularis ticksSpatiotemporal Patterns of Host-Seeking Ixodes scapularis Nymphs (Acari: Ixodidae) in the United States
Diuk-Wasser M, Gatewood A, Cortinas M, Yaremych-Hamer S, Tsao J, Kitron U, Hickling G, Brownstein J, Walker E, Piesman J, Fish D. Spatiotemporal Patterns of Host-Seeking Ixodes scapularis Nymphs (Acari: Ixodidae) in the United States. Journal Of Medical Entomology 2006, 43: 166-176. DOI: 10.1093/jmedent/43.2.166.Peer-Reviewed Original ResearchSpatiotemporal patterns of host-seeking Ixodes scapularis nymphs (Acari: Ixodidae) in the United States.
Diuk-Wasser M, Gatewood A, Cortinas M, Yaremych-Hamer S, Tsao J, Kitron U, Hickling G, Brownstein J, Walker E, Piesman J, Fish D. Spatiotemporal patterns of host-seeking Ixodes scapularis nymphs (Acari: Ixodidae) in the United States. Journal Of Medical Entomology 2006, 43: 166-76. PMID: 16619595, DOI: 10.1603/0022-2585(2006)043[0166:spohis]2.0.co;2.Peer-Reviewed Original Research
2004
Interaction and Transmission of Two Borrelia burgdorferi Sensu Stricto Strains in a Tick-Rodent Maintenance System
Derdáková M, Dudiòák V, Brei B, Brownstein J, Schwartz I, Fish D. Interaction and Transmission of Two Borrelia burgdorferi Sensu Stricto Strains in a Tick-Rodent Maintenance System. Applied And Environmental Microbiology 2004, 70: 6783-6788. PMID: 15528545, PMCID: PMC525125, DOI: 10.1128/aem.70.11.6783-6788.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachnid VectorsBorrelia burgdorferiDisease ReservoirsFemaleIxodesLyme DiseasePeromyscusRodent DiseasesTick InfestationsConceptsB. burgdorferi sensu strictoBurgdorferi sensu strictoXenodiagnostic ticksBorrelia burgdorferi sensu strictoUninfected larval ticksGroups of miceWhite-footed miceTransmission cycleControl miceInfected micePrimary infectionExperimental miceI. scapularis ticksLeucopus miceDouble infectionMiceLyme disease agentInfectionScapularis ticksMajor genotypesWeekly intervalsTransmission dynamicsExperimental groupSame strainLarval ticks