2008
MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi
Margos G, Gatewood A, Aanensen D, Hanincová K, Terekhova D, Vollmer S, Cornet M, Piesman J, Donaghy M, Bormane A, Hurn M, Feil E, Fish D, Casjens S, Wormser G, Schwartz I, Kurtenbach K. MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 8730-8735. PMID: 18574151, PMCID: PMC2435589, DOI: 10.1073/pnas.0800323105.Peer-Reviewed Original ResearchConceptsHousekeeping genesIntergenic spacerPopulation structureGeographic population structureChromosomal housekeeping genesMultilocus sequence typing (MLST) schemeB. burgdorferiPhylogenetic signalNorth AmericaEvolutionary relationshipsSequence typing schemeEvolutionary trajectoriesIGS locusSequence dataMLST schemeCultured isolatesGenesBorrelia burgdorferiOuter surface protein CMLST dataDistinct populationsSurface protein CBacterium Borrelia burgdorferiEuropean populationsVector-borne diseases
2006
Fundamental processes in the evolutionary ecology of Lyme borreliosis
Kurtenbach K, Hanincová K, Tsao J, Margos G, Fish D, Ogden N. Fundamental processes in the evolutionary ecology of Lyme borreliosis. Nature Reviews Microbiology 2006, 4: 660-669. PMID: 16894341, DOI: 10.1038/nrmicro1475.Peer-Reviewed Original ResearchConceptsEvolutionary ecologyGenetic changesMultiple-niche polymorphismVector-borne zoonosesB. burgdorferi s.Natural transmission cycleEvolutionary relationshipsEcological parallelsEvolutionary biologyVector-borne pathogensBurgdorferi s.Population fluctuationsProcess-based modelEcologySensu latoDifferent membersFundamental processesVector-borne diseasesPathogensTransmission cycleSpeciesBorrelia burgdorferi sensu latoSame fundamental questionsKey processesBurgdorferi sensu lato
2004
An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle
Tsao J, Wootton J, Bunikis J, Luna M, Fish D, Barbour A. An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 18159-18164. PMID: 15608069, PMCID: PMC536054, DOI: 10.1073/pnas.0405763102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiCommunicable DiseasesDisease ReservoirsEcologyGenotypeGlutathione TransferaseHumansImmunoenzyme TechniquesIxodesLipoproteinsLyme DiseaseMicePeromyscusPolymerase Chain ReactionRecombinant Fusion ProteinsTicksVaccinesConceptsWild white-footed miceTick infection prevalenceNegative control antigenReservoir host speciesVector-borne diseasesSympatric ticksField experimentDisease cycleB. burgdorferiDisease incidenceDisease agentsArthropod vectorsEcological approachAnimal reservoirsImmunization of humansMouse densityTicksHost speciesLyme disease agentInfection dynamicsHuman vaccinesPopulation structureWhite-footed miceOuter surface protein AHuman infections