2024
Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment
Gross G, Spiller T, Ben-Zion Z, Rubenstein A, Pietrzak R, Duek O, Hoff R, Harpaz-Rotem I. Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment. Psychological Trauma Theory Research Practice And Policy 2024 PMID: 38990694, DOI: 10.1037/tra0001734.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder clustersSymptom clustersIntrusive symptomsResidential treatmentTreatment of posttraumatic stress disorderPosttraumatic stress disorder symptomsResidential PTSD treatmentPTSD symptom clustersNovel treatment interventionsDifferential treatment responseReduce symptom severityDifferential patterns of changeAvoidance symptomsPTSD treatmentTreatment gainsStress disorderVeterans AffairsSymptom severityCluster CTreatment interventionsCluster BIndividual symptomsCohort of veteransA Brief Report of Lung Cancer Screening Utilization Prior to, During, and in the Later Stages of the COVID-19 Pandemic in the United States
Poghosyan H, Sarkar S, Richman I, Pietrzak R, Carter-Bawa L, Cooley M. A Brief Report of Lung Cancer Screening Utilization Prior to, During, and in the Later Stages of the COVID-19 Pandemic in the United States. JTO Clinical And Research Reports 2024, 100705. DOI: 10.1016/j.jtocrr.2024.100705.Peer-Reviewed Original ResearchLung cancer screeningLung cancer screening utilizationScreening utilizationBehavioral Risk Factor Surveillance SystemRates of lung cancer screeningRisk Factor Surveillance SystemScreening-eligible individualsCancer screening utilizationLung cancer burdenPopulation-based dataMultivariate logistic regressionCancer screeningCancer burdenImpact healthcareNational ratesIncreased oddsLogistic regressionNationwide effortSurveillance systemCOVID-19COVID-19 pandemicLung diseaseBrief reportNo sex differencesUnited StatesBarriers to Mental Health Care in US Military Veterans
Lewis C, Fischer I, Tsai J, Harpaz-Rotem I, Pietrzak R. Barriers to Mental Health Care in US Military Veterans. Psychiatric Quarterly 2024, 1-17. PMID: 38940875, DOI: 10.1007/s11126-024-10078-7.Peer-Reviewed Original ResearchMental health careMental health treatmentHealth careHealth treatmentReduce barriersUS veteransNegative beliefsInstrumental barriersNational Health and ResiliencePromote engagementMental health servicesPopulation-based effortsUS military veteransNationally representative dataMultivariate logistic regressionPerceived stigmaHealth servicesSocial supportPsychiatric needsVeterans StudyPractical barriersLow purposeConclusionsNearly halfMilitary veteransCareMaladaptive Health Factors as Potential Mediators for the Association Between Posttraumatic Stress Disorder and Cardiovascular Disease: A Sex-Stratified Analysis in the U.S. Adult Population
Pierce S, Reynolds K, Sommer J, El-Gabalawy R, Pietrzak R, Sumner J, Mota N. Maladaptive Health Factors as Potential Mediators for the Association Between Posttraumatic Stress Disorder and Cardiovascular Disease: A Sex-Stratified Analysis in the U.S. Adult Population. Journal Of Psychiatric Research 2024, 177: 102-108. PMID: 39002531, DOI: 10.1016/j.jpsychires.2024.06.028.Peer-Reviewed Original ResearchHealth risk factorsPosttraumatic stress disorderRisk factorsPotential mediatorsCardiovascular diseaseLow physical activityCross-sectional surveyNatural effect modelsSex-stratified analysesU.S. adult populationCardiovascular disease riskStress disorderPhysical activityNational Epidemiologic SurveyLogistic regression analysisHealth factorsEvaluate health risk factorsU.S. adultsHigher BMICausal pathwaysPrevention strategiesEffects of posttraumatic stress disorderWave 3Adult populationSubstance useHealth correlates of experiential and behavioral avoidance among trauma-exposed veterans
Schwartz E, Palmisano A, Petrakis I, Pietrzak R, Sofuoglu M. Health correlates of experiential and behavioral avoidance among trauma-exposed veterans. Journal Of Psychiatric Research 2024, 176: 213-217. PMID: 38878649, DOI: 10.1016/j.jpsychires.2024.06.014.Peer-Reviewed Original ResearchTrauma-exposed veteransExperiential avoidanceBehavioral avoidanceAnxiety symptomsDepressive symptomsMental health outcomesCognitive dysfunctionPhysical healthPhysical health outcomesHealth outcomesQuality of lifeHealth-related dysfunctionTrauma historyPsychosocial functioningCognitive functionAvoidance behaviorOutcome measuresHealth-related quality of lifeTreatment targetDistressExploratory analysisVeteransHealth-related qualityAvoidanceAnxietyPosttraumatic stress disorder and insomnia in US military veterans: Prevalence, correlates, and psychiatric and functional burden
Georgescu M, Fischer I, Beydoun M, McCarthy E, DeViva J, Pietrzak R. Posttraumatic stress disorder and insomnia in US military veterans: Prevalence, correlates, and psychiatric and functional burden. Journal Of Sleep Research 2024, e14269. PMID: 38845413, DOI: 10.1111/jsr.14269.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderMilitary veteransInsomnia groupCo-occurring posttraumatic stress disorderBurden of PTSDTreating posttraumatic stress disorderClinical management of insomniaRates of psychiatric conditionsGeneralized anxiety disorderCurrent suicidal ideationMitigate suicide riskUS veteransManagement of insomniaUS military veteransMental health burdenFunctional burdenAnxiety disordersDepressive disorderSuicidal ideationSuicide riskPsychiatric conditionsPsychosocial functioningSocial functioningInsomniaSuicide-Specific Cognitions and Suicidal Behavior in U.S. Military Veterans
Fischer I, Nichter B, Trachik B, Bryan C, Pietrzak R. Suicide-Specific Cognitions and Suicidal Behavior in U.S. Military Veterans. Psychiatry 2024, ahead-of-print: 1-10. PMID: 38832675, DOI: 10.1080/00332747.2024.2352883.Peer-Reviewed Original ResearchSuicide-specific cognitionsU.S. military veteransMilitary veteransSuicidal ideationSuicide planLifetime history of suicide attemptsHistory of suicide attemptsAssociated with suicidal ideationSuicide Cognitions ScaleDepressive symptom severityThoughts of suicideMitigate suicide riskB-SCSAdverse childhood experiencesExploratory post hoc analysisSuicidal behaviorLifetime historySuicide riskSuicide attemptsSymptom severitySuicidal thoughtsCognitive scalesIndicator of riskChildhood experiencesIntervention effortsHelping the Helpers: Mental Health Challenges of Psychosocial Support Workers During the Russian-Ukrainian War
Kang H, Fischer I, Esterlis I, Kolyshkina A, Ponomarenko L, Chobanian A, Vus V, Pietrzak R. Helping the Helpers: Mental Health Challenges of Psychosocial Support Workers During the Russian-Ukrainian War. Disaster Medicine And Public Health Preparedness 2024, 18: e95. PMID: 38829179, DOI: 10.1017/dmp.2024.68.Peer-Reviewed Original ResearchConceptsPsychosocial support workersPosttraumatic stress disorderAssociated with greater oddsPresence of meaning in lifeMeaning in lifeSuicidal ideationMental health challengesGreater oddsMental healthLow optimismSupport workersHealth challengesMental health problemsCorrelates of burnoutPromote social connectednessStress disorderPsychosocial characteristicsGreater distressWar exposureGeneral populationHealth problemsSocial connectednessBurnoutOddsSocial relationshipsObstructive Respiratory Disease in U.S. Veterans: Prevalence, Characteristics, and Health Burden
Bamonti P, Fischer I, Moye J, Poghosyan H, Pietrzak R. Obstructive Respiratory Disease in U.S. Veterans: Prevalence, Characteristics, and Health Burden. Journal Of Psychiatric Research 2024, 176: 140-147. PMID: 38857555, DOI: 10.1016/j.jpsychires.2024.05.053.Peer-Reviewed Original ResearchPhysical health burdenNationally representative sampleU.S. veteransObstructive respiratory diseaseHealth burdenRepresentative sampleNational Health and ResiliencePhysical health characteristicsRespiratory diseaseSecondary data analysisSevere somatic symptomsHealth characteristicsVA healthcareVeterans StudyTrauma burdenLow-incomeSomatic symptomsPosttraumatic stressMultivariate regression analysisVeteransMedical conditionsCurrent suicidal ideationGeneralized anxiety disorderMedical comorbiditiesNicotine use disorderCo-occurring Chronic Pain and PTSD Among US Military Veterans: Prevalence, Correlates, and Functioning
Reed D, Fischer I, Williams R, Na P, Pietrzak R. Co-occurring Chronic Pain and PTSD Among US Military Veterans: Prevalence, Correlates, and Functioning. Journal Of General Internal Medicine 2024, 1-8. PMID: 38780882, DOI: 10.1007/s11606-024-08803-w.Peer-Reviewed Original ResearchCo-occurring chronic painNationally representative sampleChronic painPosttraumatic stress disorderPsychosocial functioningUS veteransPatient Health Questionnaire-4Representative sampleShort-Form Health Survey-8Prevalence of chronic painNational Health and ResilienceAlcohol Use Disorders Identification TestChronic pain diagnosesDiagnosis of chronic painDisorders Identification TestCognitive Functioning ScaleMeasures of psychosocial functioningUS military veteransSelf-report itemsPosttraumatic Stress Disorder ChecklistHealth careVeterans StudyPain diagnosisFunctional scalesSuicidal Behaviors Questionnaire-RevisedWell-Being Domains in U.S. Military Veterans: Identifying Modifiable Factors to Promote Whole Health.
Fischer I, Na P, Feldman D, Krist A, Kudler H, Jeste D, Pietrzak R. Well-Being Domains in U.S. Military Veterans: Identifying Modifiable Factors to Promote Whole Health. International Psychogeriatrics 2024, 1-12. PMID: 38770709, DOI: 10.1017/s1041610224000589.Peer-Reviewed Original ResearchU.S. military veteransPromotion of overall healthModifiable factorsWell-beingU.S. Department of Veterans AffairsMilitary veteransDepartment of Veterans AffairsAnalyzed cross-sectional dataModel of healthcareDisease-centred modelNationally representative samplePromote well-beingWell-being domainsWhole healthCross-sectional dataModifiable healthVeterans AffairsSocial supportPsychosocial correlatesOverall healthSocioeconomic well-beingU.S. veteransDisease preventionSocioeconomic domainsRepresentative sample357. Left Nucleus Accumbens Response to Anticipatory Reward Differentiates Highly Resilient World Trade Responders
Seeley S, Schreiber Z, Block A, Astorino E, Verghese M, Norbury A, Morris L, Cahn L, Charney D, Murrough J, Stern E, Pietrzak R, Perez-Rodriguez M, Feder A. 357. Left Nucleus Accumbens Response to Anticipatory Reward Differentiates Highly Resilient World Trade Responders. Biological Psychiatry 2024, 95: s245-s246. DOI: 10.1016/j.biopsych.2024.02.856.Peer-Reviewed Original ResearchUsing the Moral Injury and Distress Scale to identify clinically meaningful moral injury
Maguen S, Griffin B, Pietrzak R, McLean C, Hamblen J, Norman S. Using the Moral Injury and Distress Scale to identify clinically meaningful moral injury. Journal Of Traumatic Stress 2024 PMID: 38655683, DOI: 10.1002/jts.23050.Peer-Reviewed Original ResearchPotentially morally injurious eventsTrauma-related guiltMoral injuryCut scoresClinically significant mental health symptomsSignificant mental health symptomsExposure to potentially morally injurious eventsSample of military veteransMental health symptomsPopulation-based sampleHealth care workersRisk of negative outcomesFunctional impairmentDepressive symptom severityMorally injurious eventsInjury carePMIE exposureNon-HispanicMental healthHealth symptomsCare workersInjury eventsPosttraumatic stressMilitary veteransSymptom severityGenome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Nievergelt C, Maihofer A, Atkinson E, Chen C, Choi K, Coleman J, Daskalakis N, Duncan L, Polimanti R, Aaronson C, Amstadter A, Andersen S, Andreassen O, Arbisi P, Ashley-Koch A, Austin S, Avdibegoviç E, Babić D, Bacanu S, Baker D, Batzler A, Beckham J, Belangero S, Benjet C, Bergner C, Bierer L, Biernacka J, Bierut L, Bisson J, Boks M, Bolger E, Brandolino A, Breen G, Bressan R, Bryant R, Bustamante A, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum A, Børte S, Cahn L, Calabrese J, Caldas-de-Almeida J, Chatzinakos C, Cheema S, Clouston S, Colodro-Conde L, Coombes B, Cruz-Fuentes C, Dale A, Dalvie S, Davis L, Deckert J, Delahanty D, Dennis M, Desarnaud F, DiPietro C, Disner S, Docherty A, Domschke K, Dyb G, Kulenović A, Edenberg H, Evans A, Fabbri C, Fani N, Farrer L, Feder A, Feeny N, Flory J, Forbes D, Franz C, Galea S, Garrett M, Gelaye B, Gelernter J, Geuze E, Gillespie C, Goleva S, Gordon S, Goçi A, Grasser L, Guindalini C, Haas M, Hagenaars S, Hauser M, Heath A, Hemmings S, Hesselbrock V, Hickie I, Hogan K, Hougaard D, Huang H, Huckins L, Hveem K, Jakovljević M, Javanbakht A, Jenkins G, Johnson J, Jones I, Jovanovic T, Karstoft K, Kaufman M, Kennedy J, Kessler R, Khan A, Kimbrel N, King A, Koen N, Kotov R, Kranzler H, Krebs K, Kremen W, Kuan P, Lawford B, Lebois L, Lehto K, Levey D, Lewis C, Liberzon I, Linnstaedt S, Logue M, Lori A, Lu Y, Luft B, Lupton M, Luykx J, Makotkine I, Maples-Keller J, Marchese S, Marmar C, Martin N, Martínez-Levy G, McAloney K, McFarlane A, McLaughlin K, McLean S, Medland S, Mehta D, Meyers J, Michopoulos V, Mikita E, Milani L, Milberg W, Miller M, Morey R, Morris C, Mors O, Mortensen P, Mufford M, Nelson E, Nordentoft M, Norman S, Nugent N, O’Donnell M, Orcutt H, Pan P, Panizzon M, Pathak G, Peters E, Peterson A, Peverill M, Pietrzak R, Polusny M, Porjesz B, Powers A, Qin X, Ratanatharathorn A, Risbrough V, Roberts A, Rothbaum A, Rothbaum B, Roy-Byrne P, Ruggiero K, Rung A, Runz H, Rutten B, de Viteri S, Salum G, Sampson L, Sanchez S, Santoro M, Seah C, Seedat S, Seng J, Shabalin A, Sheerin C, Silove D, Smith A, Smoller J, Sponheim S, Stein D, Stensland S, Stevens J, Sumner J, Teicher M, Thompson W, Tiwari A, Trapido E, Uddin M, Ursano R, Valdimarsdóttir U, Van Hooff M, Vermetten E, Vinkers C, Voisey J, Wang Y, Wang Z, Waszczuk M, Weber H, Wendt F, Werge T, Williams M, Williamson D, Winsvold B, Winternitz S, Wolf C, Wolf E, Xia Y, Xiong Y, Yehuda R, Young K, Young R, Zai C, Zai G, Zervas M, Zhao H, Zoellner L, Zwart J, deRoon-Cassini T, van Rooij S, van den Heuvel L, Stein M, Ressler K, Koenen K. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics 2024, 56: 792-808. PMID: 38637617, DOI: 10.1038/s41588-024-01707-9.Peer-Reviewed Original ResearchConceptsMeta-analysis of genome-wide association studiesGenome-wide significant lociMulti-ancestry meta-analysisGenome-wide association analysisGenome-wide association studiesIndividuals of European ancestryPotential causal genesNative American ancestryMulti-omics approachPost-traumatic stress disorderAdmixed individualsSignificant lociRisk lociCausal genesAssociation studiesAssociation analysisFunctional genesTranscription factorsGenetic studiesAmerican ancestryEuropean ancestryAxon guidanceSynaptic structureLociGenesFunctional significance of posttraumatic growth in U.S. military veterans
Gower T, Fischer I, Tsai J, Kang H, Na P, Tedeschi R, Pietrzak R. Functional significance of posttraumatic growth in U.S. military veterans. Journal Of Affective Disorders 2024, 356: 267-273. PMID: 38614442, DOI: 10.1016/j.jad.2024.04.046.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPosttraumatic stress disorder symptomsPosttraumatic growthPsychosocial functioningTraumatic eventsTrauma-exposed U.S. veteransNational Health and ResilienceMale veteran samplePost-trauma functioningPattern of findingsRetrospective self-reportsU.S. military veteransVeteran sampleStress disorderVeterans StudyExamined relationsCross-sectional designMilitary veteransNationally representative sampleU.S. veteransAssociated with functionsPhysical functionClinical interventionsPsychosocial characteristicsVeteransSex, Adverse Childhood Experiences, and Substance Use Disorders in US Military Veterans: Results From the National Health and Resilience in Veterans Study.
Moore A, Stefanovics E, Jankovsky A, Potenza M, Pietrzak R. Sex, Adverse Childhood Experiences, and Substance Use Disorders in US Military Veterans: Results From the National Health and Resilience in Veterans Study. Journal Of Addiction Medicine 2024 PMID: 38598295, DOI: 10.1097/adm.0000000000001306.Peer-Reviewed Original ResearchCurrent alcohol use disorderAlcohol use disorderSubstance use disordersDrug use disordersAdverse childhood experiencesNational Health and ResilienceUse disorderVeterans StudyChildhood experiencesSexual abuseMentally ill family memberSex moderated associationsSelf-report measuresChildhood sexual abuseUS military veteransIncarcerated family memberChildhood traumaPhysical neglectIll family memberMilitary veteransFemale veteransMale veteransFamily membersTreatment effortsModerate associationRandomized controlled trial of two internet-based written therapies for world trade center workers and survivors with persistent PTSD symptoms
Feder A, Kowalchyk M, Brinkman H, Cahn L, Aaronson C, Böttche M, Presseau C, Fred-Torres S, Markowitz J, Litz B, Yehuda R, Knaevelsrud C, Pietrzak R. Randomized controlled trial of two internet-based written therapies for world trade center workers and survivors with persistent PTSD symptoms. Psychiatry Research 2024, 336: 115885. PMID: 38603979, DOI: 10.1016/j.psychres.2024.115885.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersWTC-related PTSD symptomsMental health-related functioningPTSD symptomsSymptom clustersHealth-related functioningPosttraumatic stress disorder's avoidancePosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistPresent-centered therapyAssociated with significantly greater reductionsPersistent PTSD symptomsActive control interventionModerate-to-largeQuality of lifeSignificant main effectTreatment-by-time interactionWorld Trade Center survivorDSM-5PCL-5Stress disorderDepressive/anxiety symptomsWorld Trade CenterDepressive symptomsProblem Opioid Use Among US Military Veterans: Prevalence, Correlates, and Psychiatric Characteristics
Na P, Petrakis I, Krystal J, Pietrzak R. Problem Opioid Use Among US Military Veterans: Prevalence, Correlates, and Psychiatric Characteristics. Journal Of Addiction Medicine 2024, 18: 313-318. PMID: 38498625, PMCID: PMC11150085, DOI: 10.1097/adm.0000000000001286.Peer-Reviewed Original ResearchInstrumental activities of daily livingInstrumental activities of daily living disabilityLifetime suicide attemptsProblem opioid useUS military veteransUS veteransPsychiatric characteristicsSuicide attemptsMilitary veteransAssociated with black race/ethnicityActivities of daily livingNational Health and ResilienceLifetime alcohol use disorderMental health morbidityPosttraumatic stress disorderMental health disordersAlcohol use disorderNon-Hispanic race/ethnicityMultivariate logistic regression modelNationally representative sampleOpioid useLogistic regression modelsInstrumental activitiesHealth morbidityDaily livingObesity in Latinx and White U.S. military veterans: Mental health, psychosocial burden, non-suicidal self-injury and suicidal behavior
Stefanovics E, Grilo C, Potenza M, Pietrzak R. Obesity in Latinx and White U.S. military veterans: Mental health, psychosocial burden, non-suicidal self-injury and suicidal behavior. Psychiatry Research 2024, 335: 115844. PMID: 38484606, DOI: 10.1016/j.psychres.2024.115844.Peer-Reviewed Original ResearchNon-suicidal self-injuryDrug use disordersU.S. military veteransMental health problemsMilitary veteransSelf-injuryUse disorderSymptoms of internalizing disordersLevels of childhood traumaNational Health and ResiliencePost-traumatic stress disorderIncreased risk of mental health problemsWhite veteransCoping self-efficacyRisk of mental health problemsLatinx ethnicityGeneralized anxietyStress disorderChildhood traumaHealth problemsSuicidal behaviorVeterans StudyCorrelates of obesityCulturally sensitive preventionNationally representative sampleDifferential associations of adverse childhood experiences and mental health outcomes in U.S. military veterans
Slavin A, Fischer I, Pietrzak R. Differential associations of adverse childhood experiences and mental health outcomes in U.S. military veterans. Journal Of Psychiatric Research 2024, 172: 261-265. PMID: 38412789, DOI: 10.1016/j.jpsychires.2024.02.040.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesMental health outcomesChildhood traumaEmotional neglectMilitary veteransChildhood experiencesNational Health and ResiliencePrevalence of childhood traumaAssociated with adverse mental health outcomesHealth outcomesChildhood emotional neglectPosttraumatic stress disorderEffects of adverse childhood experiencesU.S. military veteransAssociation of adverse childhood experiencesSample of veteransAdverse mental health outcomesAdverse mental health effectsStress disorderGeneralized anxietyPopulation-based sample of veteransVeterans StudySuicidal thoughtsPopulation-based sampleIndividual adverse childhood experiences