Qing Lan, MD, PhD
Professor Adjunct of Epidemiology (Environmental Health)About
Titles
Professor Adjunct of Epidemiology (Environmental Health)
Professor Adjunct, Environmental Health Sciences
Biography
Dr. Qing Lan a world leader in environmental and occupational exposures, human health studies and gene environment interaction. Her research focuses on molecular epidemiologic studies of populations exposed to several classes of chemical compounds that are known or suspected occupational and environmental carcinogens. She is one of YSPH’s main collaborators at NCI studying environmental exposures, genetic susceptibility for NHL and multiple myeloma, indoor air pollution and gene polymorphisms for lung cancer risk in Xuanwei, China. She has mentored several YSPH PhD candidates.
Dr. Lan received her M.D. at Weifang Medical University and her Ph.D. in molecular epidemiology at the Chinese Academy of Preventive Medicine in Beijing, as part of a joint training program with the United States Environmental Protection Agency and University of North Carolina at Chapel Hill, and received her MPH at Johns Hopkins University.
Appointments
Environmental Health Sciences
Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- Chinese Academy of Preventive Medicine (2001)
- MD
- Weifang Medical College (1985)
Research
Overview
Public Health Interests
ORCID
0000-0002-8468-4942
Research at a Glance
Yale Co-Authors
Publications Timeline
Melissa Friesen
Huey Cai
Publications
2025
Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort
Babigumira R, Veierød M, Larsen I, Berge L, Shala N, Marjerrison N, Samuelsen S, Bråtveit M, Kirkeleit J, Nordby K, Hosgood H, Demers P, Vermeulen R, Kromhout H, Engel L, Nilsen T, Silverman D, Friesen M, Rothman N, Lan Q, Grimsrud T, Stenehjem J. Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort. Environmental Research 2025, 276: 121407. PMID: 40118315, DOI: 10.1016/j.envres.2025.121407.Peer-Reviewed Original ResearchConceptsRisk of colorectal cancerOffshore petroleum workersJob-exposure matrixHazard ratioColorectal cancerAnatomic subsiteColorectal cancer riskConfidence intervalsColorectal cancer casesEstimate hazard ratiosCase-cohort analysisPetroleum workersWork historyExposure-response associationsPositive exposure-response associationsBody mass indexRight-sided colon cancerPublic health implicationsPhysical activityBenzene exposureMeat intakeAlcohol intakeQuartile 4Mass indexCase cohortHSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism
Imani P, Grigoryan H, Dudoit S, Shu X, Wong J, Zhang L, Zhang J, Hu W, Cai Q, Gao Y, Blechter B, Rahman M, Zheng W, Rothman N, Lan Q, Rappaport S. HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism. Antioxidants 2025, 14: 335. PMCID: PMC11939640, DOI: 10.3390/antiox14030335.Peer-Reviewed Original ResearchConceptsPolycyclic aromatic hydrocarbonsNever-smokersAir pollutionLung cancerOne-carbon metabolismAirborne fine particulate matterLung adenocarcinomaUrinary polycyclic aromatic hydrocarbonsFine particulate matterShanghai Women's Health StudyWomen's Health StudySmoking-related cancersReactive oxygen speciesIncidence of lung adenocarcinomaAromatic hydrocarbonsLung cancer casesParticulate matterEast Asian womenHealth StudyCancer casesAsian womenDietary factorsPollutionHuman serum albuminHigher incidenceSex Differences in Anti–Epstein-Barr Virus Antibody Responses
Jackson S, Francis J, Pfeiffer R, Proietti C, Coghill A, Yu K, Sarathkumara Y, Hsu W, Argirion I, Wang C, Chen C, Rothman N, Lan Q, Hildesheim A, Doolan D, Liu Z. Sex Differences in Anti–Epstein-Barr Virus Antibody Responses. The Journal Of Infectious Diseases 2025, jiaf067. PMID: 39932888, DOI: 10.1093/infdis/jiaf067.Peer-Reviewed Original ResearchOverview of historical occupational exposure to trichloroethylene in China
Nie J, Ge C, Rothman N, Hu W, Vermeulen R, Lan Q, Peters S. Overview of historical occupational exposure to trichloroethylene in China. Annals Of Work Exposures And Health 2025, 69: 251-260. PMID: 39851217, PMCID: PMC11911510, DOI: 10.1093/annweh/wxae103.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsSensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
The need for a cancer exposome atlas: a scoping review
Young A, Mullins C, Sehgal N, Vermeulen R, Kolijn P, Vlaanderen J, Rahman M, Birmann B, Barupal D, Lan Q, Rothman N, Walker D. The need for a cancer exposome atlas: a scoping review. JNCI Cancer Spectrum 2024, 9: pkae122. PMID: 39700422, PMCID: PMC11729703, DOI: 10.1093/jncics/pkae122.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCancer riskGenetic susceptibility to cancerStudy design limitationsSusceptibility to cancerCancer heritabilitySocial determinantsCancer epidemiologyExposome approachProspective associationsExternal risk factorsCancer casesPrimary preventionUnmet opportunitiesCancer researchChemical exposure profilesEnvironmental exposuresRisk factorsExposomeEvaluate progressCancer typesCancerRiskExposure profilesEnvironmental influencesLifestyleGenome-Wide Meta-Analysis Identifies Multiple Germline Genetic Variants Associated with Increased Risk of Follicular Lymphoma
Joseph V, Clay-Gilmour A, Park H, Breeze C, Sucheston-Campbell L, Arias J, Waller R, Güler M, Nieters A, Ekstroem Smedby K, Davídsson Ó, Wang S, Lan Q, Hjalgrim H, Slager S, McKay J, Cerhan J, Berndt S, Rothman N. Genome-Wide Meta-Analysis Identifies Multiple Germline Genetic Variants Associated with Increased Risk of Follicular Lymphoma. Blood 2024, 144: 4339-4339. DOI: 10.1182/blood-2024-211262.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesTranscriptome wide association studyBlood cell traitsLeukocyte telomere lengthMendelian randomizationGermline genetic variantsB cell developmentClass II genesFollicular lymphomaAssociation studiesHLA class IRisk variantsGenetic variantsFL casesGenome-wide significant lociGenome-wide significant variantsWhole blood gene expression dataHLA regionII genesRegulation of B cell developmentBlood gene expression dataControls of European ancestryGene Ontology termsGene set analysisGenetically high-risk populationsAssociation between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium
Kishida R, Yin X, Abe S, Rahman S, Saito E, Islam R, Lan Q, Blechter B, Rothman N, Sawada N, Tamakoshi A, Shu X, Hozawa A, Kanemura S, Kim J, Sugawara Y, Park S, Kweon S, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Zheng W, Inoue M, Kang D, Seow W. Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium. International Journal Of Cancer 2024, 156: 723-733. PMID: 39361428, PMCID: PMC11661513, DOI: 10.1002/ijc.35191.Peer-Reviewed Original ResearchConceptsFamily history of lung cancerAsia Cohort ConsortiumCohort ConsortiumLC incidenceSmoking statusFamily historyHazard ratioRisk of lung cancerIncreased risk of lung adenocarcinomaHistory of lung cancerConfidence intervalsLung cancer incidenceSignificant effect modificationEstimate hazard ratiosIncreased riskPopulation-based cohortCox proportional hazards regression modelsRisk of lung adenocarcinomaProspective cohort studyAssociated with increased riskLung cancerProportional hazards regression modelsEthnic groupsHazards regression modelsCancer incidenceContext-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes
Long E, Yin J, Shin J, Li Y, Li B, Kane A, Patel H, Sun X, Wang C, Luong T, Xia J, Han Y, Byun J, Zhang T, Zhao W, Landi M, Rothman N, Lan Q, Chang Y, Yu F, Amos C, Shi J, Lee J, Kim E, Choi J. Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes. Nature Communications 2024, 15: 7995. PMID: 39266564, PMCID: PMC11392933, DOI: 10.1038/s41467-024-52356-9.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsGenome-wide association studiesGenome-wide association study lociSusceptibility genesLung cancer susceptibility genesTranscription factor footprintsChromatin accessibility mapsCis-regulatory elementsRisk-associated variantsRare cell typesRegulate gene expressionCell typesCell type-specificCancer susceptibility genesCausal variantsAssociation studiesGene regulationGene functionMultiomics approachTarget genesLociGene expressionGenesType-specificHuman lung cellsCCREsSRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma
Chen H, Gao S, Wang P, Xie M, Zhang H, Fan Y, Nie E, Lan Q. SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma. Environmental Toxicology 2024, 40: 66-78. PMID: 39258423, DOI: 10.1002/tox.24396.Peer-Reviewed Original ResearchConceptsRNA-binding proteinsP53 signalingInhibits Mdm2-mediated p53 ubiquitinationMDM2-mediated p53 ubiquitinationRPL11-MDM2-p53 pathwayElevated p53 levelsRibosomal protein expressionBinding to MDM2Tumor-associated macrophagesP53 signaling pathwayInactivation of p53P53 ubiquitinationRibosomal proteinsRNA translationM2 macrophage polarizationP53 levelsTumor growthRPL11Mouse xenograft modelEctopic expressionGlioma tumor growthCell cycleBinding proteinTarget genesSignaling pathway