Qing Lan, MD, PhD
Professor Adjunct of Epidemiology (Environmental Health)DownloadHi-Res Photo
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Professor Adjunct of Epidemiology (Environmental Health)
Professor Adjunct, Environmental Health Sciences
Biography
Dr. Qing Lan a world leader in environmental and occupational exposures, human health studies and gene environment interaction. Her research focuses on molecular epidemiologic studies of populations exposed to several classes of chemical compounds that are known or suspected occupational and environmental carcinogens. She is one of YSPH’s main collaborators at NCI studying environmental exposures, genetic susceptibility for NHL and multiple myeloma, indoor air pollution and gene polymorphisms for lung cancer risk in Xuanwei, China. She has mentored several YSPH PhD candidates.
Dr. Lan received her M.D. at Weifang Medical University and her Ph.D. in molecular epidemiology at the Chinese Academy of Preventive Medicine in Beijing, as part of a joint training program with the United States Environmental Protection Agency and University of North Carolina at Chapel Hill, and received her MPH at Johns Hopkins University.
Last Updated on April 07, 2025.
Appointments
Environmental Health Sciences
Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- Chinese Academy of Preventive Medicine (2001)
- MD
- Weifang Medical College (1985)
Research
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Overview
Public Health Interests
Environmental Health; Biomarkers
ORCID
0000-0002-8468-4942
Research at a Glance
Yale Co-Authors
Frequent collaborators of Qing Lan's published research.
Publications Timeline
A big-picture view of Qing Lan's research output by year.
Melissa Friesen
Huey Cai
58Publications
197Citations
Publications
2025
Correction: Case Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas
Tang R, Chen Y, Wan D, Xiang Y, Chen S, Chen H, Dai X, Rong R, Xiao S, Lan Q, Wang H, Huang S. Correction: Case Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas. Frontiers In Oncology 2025, 15: 1748919. PMID: 41415545, PMCID: PMC12709116, DOI: 10.3389/fonc.2025.1748919.Peer-Reviewed Original ResearchTMEM165 promotes glioblastoma progression through epithelial-mesenchymal transition-mediated invasion and temozolomide chemoresistance
Cheng H, Ding Y, Shen X, Wang Q, Zhang Z, Wang Y, Chen S, Zhuo S, Wang K, Yang L, Ji F, Fu Z, Lan Q, Yang K. TMEM165 promotes glioblastoma progression through epithelial-mesenchymal transition-mediated invasion and temozolomide chemoresistance. International Journal Of Biological Macromolecules 2025, 335: 149216. PMID: 41308767, DOI: 10.1016/j.ijbiomac.2025.149216.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsEpithelial-mesenchymal transitionTMEM165Regulatory proteinsPoor prognosisBioinformatics analysisEnrichment analysisEMT-related proteinsAssociated with shorter survivalHigh tumor gradeWild-type statusSensitivity to temozolomideOncogenic roleCentral nervous systemTherapeutic targetGlioblastoma proliferationGlioblastoma progressionProteinTumor gradeIn vivoShorter survivalMalignant tumorsAggressive natureGlioma patientsTemozolomideIn vitro experimentsCase Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas
Tang R, Chen Y, Wan D, Xiang Y, Chen S, Chen H, Dai X, Rong R, Xiao S, Lan Q, Wang H, Huang S. Case Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas. Frontiers In Oncology 2025, 15: 1694881. PMID: 41323387, PMCID: PMC12660100, DOI: 10.3389/fonc.2025.1694881.Peer-Reviewed Original ResearchConceptsChromosome lossDysembryoplastic neuroepithelial tumorMalignant transformationSignaling pathwayMAPK pathwayBrain tumorsMalignant transformation of low-grade gliomasMitogen-activated protein kinase (MAPK) signaling pathwayCases of high-grade gliomasMAPK signaling pathwayHigh-grade astrocytomasHigh-grade gliomasLow-grade gliomasBenign brain tumorsCellular transformationCritical genesFGFR1 mutationsNeuroepithelial tumorsMAPK alterationsDiffuse astrocytomasPilocytic astrocytomaMutationsGene mutationsMAPKTumorHigher lung cancer risk among female never-smokers than males in a large married couple study
Cai H, Shu X, Wu S, Gao Y, Lan Q, Rothman N, Zheng W, Yang G. Higher lung cancer risk among female never-smokers than males in a large married couple study. Lung Cancer 2025, 210: 108836. PMID: 41237664, DOI: 10.1016/j.lungcan.2025.108836.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsIncidence rate ratiosAge-standardized incidence rateLung cancer riskHazard ratioCancer riskIncidence rateHigher lung cancer riskAge-standardized ratesIncident lung cancerIntensity of cigarette smokingFemale never-smokersDual-smoker couplesEver smokingNever smokersRate ratiosCox regression modelsNever-smokersCohort studyMultivariable adjustmentCigarette smokingLung cancerSex differencesRegression modelsCohortSmokingTime-dependent relationship between urinary biomarkers of nucleic acid oxidation and colorectal cancer risk
Zhao Y, Nogueira M, Milne G, Gao Y, Cai Q, Lan Q, Yi H, Rothman N, Shu X, Zheng W, Chen Q, Yang G. Time-dependent relationship between urinary biomarkers of nucleic acid oxidation and colorectal cancer risk. Journal Of The National Cancer Institute 2025, djaf312. PMID: 41181902, DOI: 10.1093/jnci/djaf312.Peer-Reviewed Original ResearchAltmetricConceptsColorectal cancer riskOdds ratioU.S. cohortColorectal cancerInverse associationIncident colorectal cancerMultivariable-adjusted odds ratioIncident CRC casesShanghai cohortColorectal cancer casesUrinary markersUrinary biomarkersYear of enrollmentSystemic OxSCRC casesNo significant associationCancer riskMedian Follow-UpSignificant associationPrimary analysisChemoprevention strategiesOxS markersMarker of DNA oxidationFollow-upTumor developmentExposure to household air pollution in relation to stomach and esophageal cancer in Xuanwei, China
Blechter B, Portengen L, Downward G, Bassig B, Hu W, Wong J, Rahman M, Zhang Y, Ning B, Li J, Yang K, Keil A, Hosgood H, Silverman D, Rothman N, Huang Y, Vermeulen R, Lan Q. Exposure to household air pollution in relation to stomach and esophageal cancer in Xuanwei, China. Environment International 2025, 205: 109889. PMID: 41202457, DOI: 10.1016/j.envint.2025.109889.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsHousehold air pollutionEsophageal cancer mortalityCancer mortalityStomach cancer mortalityExposure to household air pollutionRisk of stomachCause-specific mortalityBirth cohortSmoking statusStratified analysisStomach cancerRisk differenceHealth burdenAir pollutionGlobal health burdenCox regressionAnnual exposureEsophageal cancerAssociationMortalityPolycyclic aromatic hydrocarbonsCoal useCohortXuanweiCancer8249601 Benzene exposure and risk of colorectal cancer in the Norwegian offshore petroleum workers cohort
Babigumira R, Veierød M, Larsen I, Berge L, Shala N, Marjerrison N, Samuelsen S, Bråtveit M, Kirkeleit J, Nordby K, Dean Hosgood H, Demers P, Vermeulen R, Kromhout H, Engel L, Nilsen T, Silverman D, Friesen M, Rothman N, Lan Q, Grimsrud T, Stenehjem J. 8249601 Benzene exposure and risk of colorectal cancer in the Norwegian offshore petroleum workers cohort. 2025, a1.2-a1. DOI: 10.1136/oemed-2025-epicohabstracts.2.Peer-Reviewed Original Research8287355 Assessing the effectiveness of automatically assigning occupational exposure modules in a multi-center hospital-based case-control study in Asia
Friesen M, Locke S, Josse P, Ge C, Xu J, Lam T, Kwong Y, Bassig B, Hu W, Fritschi L, Sadkowsky T, Purdue M, Liang R, Chan J, Chen K, Xu C, Su Y, Chiu B, Hosgood D, Rothman N, Lan Q, Vermeulen R. 8287355 Assessing the effectiveness of automatically assigning occupational exposure modules in a multi-center hospital-based case-control study in Asia. 2025, a84.2-a85. DOI: 10.1136/oemed-2025-epicohabstracts.204.Peer-Reviewed Original ResearchEEG‐Based Deep Learning Model for Hyper‐Acute Large Vessel Occlusion Stroke Detection in Mice
Zhang T, Li X, Hu X, Zhou Z, Mu Q, Chai X, Lan Q, Zhao J. EEG‐Based Deep Learning Model for Hyper‐Acute Large Vessel Occlusion Stroke Detection in Mice. CNS Neuroscience & Therapeutics 2025, 31: e70592. PMID: 41014019, PMCID: PMC12475507, DOI: 10.1111/cns.70592.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsDeep learning modelsLearning modelsLarge vessel occlusionHyper-acute phaseStroke detectionEffective feature extractionDeep learning architectureEEG dataAccurate detectionLearning architectureFeature extractionF1 scoreClassification accuracyEEG signalsT-SNESham-operated miceLarge vessel occlusion strokeHigh-resolution EEG dataMultiple metricsReal-timeRobust performancePrehospital settingEEG changesDiagnostic performanceT-SNE analysisBenzene Metabolism Is Dominated by a High-Affinity Pathway at Ambient Exposures with Implications for Cancer Risks
Thomas R, Kim S, Lan Q, Vermeulen R, Zhang L, Rothman N, Smith M, Rappaport S. Benzene Metabolism Is Dominated by a High-Affinity Pathway at Ambient Exposures with Implications for Cancer Risks. International Journal Of Molecular Sciences 2025, 26: 8550. PMID: 40943470, PMCID: PMC12428784, DOI: 10.3390/ijms26178550.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHigh-affinity pathwayMichaelis-Menten-like modelLow-affinity pathwayMetabolic pathwaysToxic benzene metabolitesInitial metabolismPathwayNonsmoking malesComplex metabolismMetabolismLow affinityHigher affinitySmoking malesCancer riskLung metabolismAir concentrationsMetabolic rateTwo-pathway modelBlood cancerLiver metabolismBioactivation of benzeneAmbient benzene concentrationsLung adenomasLung-cancer incidenceNever smokers
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